Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 29, Issue 2
Displaying 1-12 of 12 articles from this issue
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Contents
  • Studies on Collagen in the Human Uterus
    Its Biochemical Changes during Pregnancy, Delivery and Postpartum Involution
    SACHIHIKO YAMAMOTO
    1983 Volume 29 Issue 2 Pages 166-176
    Published: June 10, 1983
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.29.166
    JOURNAL FREE ACCESS
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    In order to study the physiological changes in collagen of the human pregnant and postpartum uterine tissue, the hydroxyproline content, the solubility of collagen and the activities of prolyl hydroxylase in the samples obtained from the cervix and the body of the normal human uterus were studied. The results were as follows : 1. Hydroxyproline contents in the uterine cervix during pregnancy and postpartum were slightly less than that of nonpregnant controls. The lowest level was observed immediately after delivery, but, on the fourth day postpartum, it increased to more than that obtained immediately after delivery. In the uterine body, there was no remarkable change in its content during pregnancy, but it decreased remarkably immediately after delivery. 2. Pepsin-soluble collagen in the uterine cervix increased significantly immediately after delivery compared with nonpregnant controls, but, on the fourth day postpartum, it decreased significantly compared with that immediately after delivery. In the uterine body, no significant change in solubility was observed throughout pregnancy. 3. Prolyl hydroxylase activity in the uterine cervix was slightly elevated during pregnancy and at the time of delivery, and the highest level was observed on the fourth day postpartum. On the other hand, in the uterine body the highest activity was observed immediately after delivery. 4. The stimulative or suppressive effects on proliferation of fibroblasts cultured in vitro were observed in two groups administered 17β-estradiol or estriol, respectively. They were considered presumably due to the difference of doses between the two steroids used. Progesterone showed a more suppressive effect on cell proliferation. These findings suggest that there are significant and definite biochemical changes in human uterine collagen during pregnancy, at the time of delivery and the postpartum period under the presumptive effects of female sex steroids. And, from these data, one can also deduce that collagen might play an important role in the enlargement and distention of the uterine body, softening of the cervix and postpartum involution.
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  • Angiographic Studies on Breast Cancer
    NAOYUKI SEKINE
    1983 Volume 29 Issue 2 Pages 177-190
    Published: June 10, 1983
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.29.177
    JOURNAL FREE ACCESS
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    Angiography of the breast was studied in 93 cases of cancer, 34 of mastopathy and seven of fibroadenoma 1) The most important feeding arteries in breast cancer are the internal mammary, lateral thoracic and superficial thoracic. 2) In breast cancer compared with benign tumor there were seven abnormal findings : chaotic arrangement, straight course, irregular tortuosity, dilated vessels, hypervascularity, lymph node stain and tumor stain (p<0.05). 3) The diagnostic rate of breast cancer by angiography was 86.0%. With tumor whose maximum diameters were less than 2.0cm, it was 73.1%. The diagnostic rate of these small tumors was significantly higher with angiography than when other methods were used. In medullary tubular carcinoma, angiographic diagnosis was most effective, with a diagnostic rate of 95.8%. 4) In the high-density tumor stain, vessels of less than 200 micron caliber were increased and dilated, and fibrostomal reaction and density of the cancer nest were high. It was suspected that the density of tumor stain was related to hematogeneous metastasis and has some effect on chemotherapy. 5) Lymph node stain of carcinoma seemed not to be related to metastatic lymph node.
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  • Experimental Studies on the Contractility of Chronic Pressure-overloaded Hypertrophied Heart
    - Pressure-volume and Pressure-velocity Relations -
    HIROYUKI SATO
    1983 Volume 29 Issue 2 Pages 191-203
    Published: June 10, 1983
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.29.191
    JOURNAL FREE ACCESS
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    The contractile performance of the rabbit left ventricle during chronic pressure-overloaded hypertrophy without failure was studied. About four weeks after constriction procedure of the descending aorta, the heart was isolated and retrograde coronary perfusion was established with modified Krebs solution. A latex balloon was inserted into the left ventricular cavity, and the intraventricular volume could be changed with a constant velocity by a magnetic shaker connected to the balloon. The pressure-volume relation and the relation between pressure and volume-velocity of the left ventricle were determined and compared with those of normal controls. The isovolumic developed pressures at any ventricular volume were larger in the hypertrophied heart than in the normal. However, the calculated wall stress plotted against the relative volume (the volume relative to the volume at which the maximum pressure was developed) was smaller in the hypertrophied heart. The pressurevelocity relation of the left ventricle was measured by the isovelocity method. The relationship in the hypertrophied as well as the normal heart could be adequately approximated with a hyperbolic equation. The maximum pressure was larger, but the maximum velocity was smaller, in the hypertrophied heart than in the normal. It is concluded that the left ventricular stress and the maximum velocity decreased in connection with pressure-overloaded hypertrophy in spite of an increase in the maximum pressure. These results indicate that the contractile performance decreases in the chronic pressure-overloaded hypertrophied heart.
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