Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 22, Issue 4
Displaying 1-15 of 15 articles from this issue
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Contents
  • Macroscopic Findings and Lymphatic Metastasis of Gastric Cancer Infiltrating into Tunica Muscularis Propria
    MASAFUSA MIYAKE
    1976 Volume 22 Issue 4 Pages 389-413
    Published: December 10, 1976
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.22.389
    JOURNAL FREE ACCESS
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    In order to decide the grade of dissection of regional lymph nodes in operation of early gastric cancer, the macroscopic and histological findings of cancer, the method of operation and five year survival rate were compared in 84 cases with gastric cancers infiltrating into tunica muscularis propria (pm gastric cancer) and in 100 cases with gastric cancers infiltrating into submucosal layer (sm gastric cancer). Pm gastric cancers were macroscopically classified into two groups. One group was in pm early cancer type (27 cases), most of which were similar to cancer of II c type in the macroscopic classification of early gastric cancer, and another was in pm Borrmann type (57 cases), most of which were identified with cancer of II type in Borrmann's classification. Rates of regional lymph node involvement in these two groups were 29.6% in pm early cancer type and 56.9% in pm Borrmann type, while the rate in sm gastric cancer was 19.0%. Five year survival rates were 93.8% in pm early cancer type and 54.2% in pm Borrmann type, while the rate in sm cancer was 95.1%. Although the infiltration into submucosal layer in pm early cancer type was more extensive than that in sm cancer, five year survival rate in the pm early cancer type was very close to that of sm cancer. In the each group classified according to the grade of regional lymph nodes dissection mber), five year survival rates in pm early cancer type were 83.3% in Rl, 100% in both R2 (R-nuand R3. The rates in the pm Borrmann type were 27.3% in Rl, 70.0% in R2 and 100% in R3, while in the cases with lymph node involvement the rates were 0% in Rl, 50.0% in R2 and 100% in R3. These results indicated that in order to get a good result of operation R2 dissection of the regional lymph nodes would be markedly effective in the pm early cancer type and R3 dissection of the regional lymph nodes (extended radical operation) would be necessary in the pm Borrmann type.
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  • Induction of Irreversible Vaginal Cornification by Neonatal Estrogen Treatment in Feminized Male Mice.
    YOSHIHIDE SUZUKI
    1976 Volume 22 Issue 4 Pages 414-420
    Published: December 10, 1976
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.22.414
    JOURNAL FREE ACCESS
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    Pregnant female ICR/Swiss mice were injected with 6 mg of cyproterone acetate (CA) from days 14 to 20 of pregnancy. Offsprings were delivered on day 20 of pregnancy by Caesarian section and castrated at the same time under cold anesthesia. Then, animals were foster-nursed by other lactating females. Feminized male offsprings were divided into 3 groups and treated once daily for the first 10 days of life with sesame oil (Group 1), 20 μg estradiol-17 β (ED) (Group 2) and 50 μg ED (Group 3), respectively. The animals were sacrificed at 60 days of age. Histological examination showed that a vagina which anteriorly ended blindly developed in all feminized male mice. In most of these feminized males, insufficient development of urethrovaginal septum was noted. However, the separation of the urogenital sinus into the ventral urinary tract and the dorsal vagina was easily identified by their histological appearances. In oil-injected controls (Group 1), the vaginal epithelium consisted of 2-4 cell layers and exhibited the stratified squamous and/or cuboidal structures, but there was no sign of cornification. In contrast, the vaginal eqithelium of estrogenized feminized males showed long-lasting hyperplasia after the withdrawal of exogenous estrogen. In 2 out of 15 feminized males of Group 3, well-differentiated squamous stratification and intensive cornification were found from the anterior to posterior parts of the vaginal epithelium. In most of the rest animals, cornification was found limited to the middle and posterior parts of the vagina, although hyperplasia of the vaginal eqithelium (7-8 cell layers) was consistently observed throughout all parts of the vagina. Since the most parts of the vaginal anlage of CA-induced feminized males in thought to be originated from the urogenital sinus epithelium, persistent cornification in the middle and posterior parts of the vagina observed in the present study may indicate the possible contribution of sinus-orginated epithelial cells to “estrogen independent vaginal cornification'”.
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  • The Study on Deglycerolized Red Blood Cells
    --especially Abouta Method of the Deglycerolization--
    HIROO YOKOTA
    1976 Volume 22 Issue 4 Pages 421-443
    Published: December 10, 1976
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.22.421
    JOURNAL FREE ACCESS
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    1. Purpose of the study : The Acid Citrate Dextrose (ACD) blood is usually impossible to be preserved for more than three weeks. Howerer, if red blood cells are glycerolized and frozen at ultra-low temperature, i.e. -85°C or-196°C, it would be possible to preserve the blood for the longer time. In the process of freezing, thawing and deglycerolization of blood, deglycerolization has been considered to be the most difficult procedure. The other problems of ACD blood are a infection of serum hepatitis and antibodies production following transfusion. The present study was performed about the polybrene-heparin reversible agglomeration of red blood cells which contributed to an easy deglycerolization. The incidence of hepatitis-B following blood transfusion were compared between in ACD blood and in the frozen blood which the author prepared. 2. Materials and Methods : Red blood cells frozen by slow or rapid freezing method and deglycerolized by each of three methods (reversible agglomeration, continuous centrifugation, or serial centrifugation) were compared biochemically and functionally. In 492 patients injected ACD blood and 193 patients injected the frozen blood from Jan. 1972 to Dec. 1973, the occurence of hepatitis-B and the prognosis were investigated. 3. Results and Conclusion : Red cells frozen, thawed and deglycerolized were proved nor inferior to the fresh blood : ATP and 2, 3-DPG maintained well in the forzen red cells and the surviral time was almost the same between them. The polybrene-heparin reversible agglomeration method was proved to be excellent and available in standardization and reproducibility of blood preservation. In 94 out of 492 patients transfused ACD whole blood, hepatitis-B were found (19.1%). On the other hand, in 66 patients transfused the frozen blood no hepatitis-B was detected. This result indicated that a washing effect by deglycerolization, was more effective about 500 times than by the previous methods, and when HB antigen positive bloods were washed by the reversible agglomeration, the antigen became negative. 4. Frozen blood method was best for removing leukocyte compared with conventional washed blood or leukocyte removed blood. Autotransfusion was also applied in gastric surgery. Clinical use of autotransfusion will be able to eliminate the infection of hepatitis-B, antibodies production and complicated crossmatch testing. The frozen blood prepared by above mentioned method was proved to be clinically superior to ACD blood in longterm preservation and its purification, resolving many problems in blood transfusion.
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  • Two Cases of 18 Trisomy
    HITOSHI IWASAKI, YOSHIRO BABA
    1976 Volume 22 Issue 4 Pages 444-449
    Published: December 10, 1976
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.22.444
    JOURNAL FREE ACCESS
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    The first case was a 4-hour-old male infant who had multiple anomalies in his face, hands and feet. He died of apnea attack 3 days after admission. Autopsy revealed dextrocardia, ventricular septal defect, patent ductus arteriosus, horseshoe kidney, Meckel's diverticulum and cerebellar atrophy. The second case was a 1-day-old female infant who was admitted because of multiple anomalies of her face and hands, and bradycardia. Since electrocardiogram revealed complete A-V block, isoproterenol drip infusion was performed but 4 hour after that she died. Autopsy was not permitted. Chromosome analysis of the patients disclosed the karyotypes as 47, XY, + 18, 47, XX, + 18 respectively.
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