Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 36, Issue 3
Displaying 1-18 of 18 articles from this issue
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Contents
  • Possible role of estrogen in development of sexal dimorphism in the anterovenral periventricular nucleus of preoptic area in the rat
    HIROYUKI TAKEUCHI
    1990 Volume 36 Issue 3 Pages 340-347
    Published: October 20, 1990
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.340
    JOURNAL FREE ACCESS
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    The anteroventral periventricular nucleus of the preoptic area (AVPvN) is significantly larger in females than in males. In the present experiment, the changes in the volume of the AVPvN were examined at various stages of development in males and females. The volume of the AVPvN was measured in rats at the age of 15, 20, 30, 45, 90days. A significant increase was noted during the peripubetal and postpubertal period, while the males showed no significant increase throughout their life. The difference in females was clear after the age of 45 days but was not seen before the age of 30 days. Rats were injected with 20 IU of pregnant mare serum gonadotropin (PMSG) at 27 days of age and the others were injected for 3 days with estradiol benzoate after castration at the age of 27 days, these females were killed 3 days later. The volume of the AVPvN in both groups was significantly larger than that in the control group, being almost the same as that at the age of 45 days. The rats castrated at the age of 27 days and injected with 20 IU of PMSG showed no significant difference in size of the AVPvN 3 days later, compared to control group. These results show that a male-female difference in the AVPvN size in rats becomes evident around the onset of puberty and its expression is facilitated by increased levels of estrogen in the pubertal females.
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  • Consultation-liaison psychiatric activities in the inpatient services at Juntendo University Hospital
    NORIHIKO IWAMOTO, KOU ETO, MINORU ARAI, KAZUYA YOSHIZAWA, SHIGERU AKAZ ...
    1990 Volume 36 Issue 3 Pages 348-354
    Published: October 20, 1990
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.348
    JOURNAL FREE ACCESS
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    Consultaion-liaison activities as an inpatient service at Juntendo University Hospital were studied. For the last 3 years, 91 inpatients (35 men and 56 women, mean age : 47.8 years old) took our psychiatric treatment. All services except those of anesthesia requested our consultation. The main reasons for consultation were psychomotor-excitement (24.2%), symptoms based on a mental illness (20.9%) and depressive symptoms (17.6%). Patients with a mental illness had been treated as psychiatric outpatients before this admission. The consulted patients were diagnosed with acute organic brain syndrome (delirium) (22.0%), psychogenic reaction (20.9%), and schizophrenia (12.1). The psychiatric symptoms first appeared after the admission in most of them (79.1%).
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  • A comparison of the electrocardiographic abnormalities between biopsy-proven myocarditis-and dilated cardiomyopathy-cases
    HIROO OHI
    1990 Volume 36 Issue 3 Pages 355-366
    Published: October 20, 1990
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.355
    JOURNAL FREE ACCESS
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    Of the endomyocardial biopsy cases of clinically suspected dilated cardiomyopathy and non-specific myocarditis examined at Juntendo University Hospital and the Cardiovascular Institute Hospital, Tokyo, between 1979 and 1989, 49 cases of non-specific myocarditis (Myo), 54 of postmyocarditic cardiomegaly (PMC) and 14 of dilated cardiomyopathy (DCM) were selected from the following histological criteria : i. e. monocytic infiltration including lymphocytes for Myo ; myocardial fibrosis of replacement and/or interstitial type, proliferation of small vessels, myocyte-hypertrophy and disarrangementfor PMC ; and nonspecific myocyte-degeneration, hypertrophy and fibrosis for DCM. The EKG features were as folloes : (1) Ventricular arrhythmias including ventricular tachycardia and specific negative T waves (prominent symmetrical negative T appeared in V5, sand/or aVF) were dominantly observed in Myo and PMC. (2) Biphasic P and negative T in VI were characteristic in Myo. (3) Supra-ventricular arrhythmias including atrial fibrillation (flutter) and Sick Sinus Syndrome, and right bundle branch block appeared in PMC with a higher incidence than in other groups. (4) Nonspecific ST-T change (sagging ST segment), left bundle branch block and left axis deviation of the QRS complexes were dominant in DCM. Although the biopsy diagnosis of Myo and PMC were expected correct when the positive findings appeared under a microscope, the tendency of focal distribution of chronic inflammtory lesions increase the chance of the biotome escaping from an adequate samplig site. It would lead to erroneous diagnosis of some Myo and PMC cases as DCM. Nonetheless, the characterisitic EKG change in Myo, PMC and DCM could improve the differential diagnosis of these previously obscure categories of myocardial diseases.
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  • Auditory-evoked potentials in senile dementia
    Comparison with senile dementia of Alzheimer type and vascular dementia
    MASAHIRO SHINOMIYA
    1990 Volume 36 Issue 3 Pages 367-380
    Published: October 20, 1990
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.367
    JOURNAL FREE ACCESS
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    We estimated the latency and amplitude of auditory-evoked potentials, including auditory brainstem response (ABR), middle latency response (MLR), and slow vertex response (SVR), and clarified the characteristics of the auditory-evoked potentials associated with aging and dementia. The subjects were 73 people above 65 years of age, including 20 normal aging subjects, 21 patients with vascular dementia (VD), and 32 patients with senile dementia of the Alzheimer type (SDAT). Ten young normal subjects in their twenties were examined as controls. The acoustic stimuli were a click and a toneburst. The intensity of the stimuli was 60dB above their hearing threshold ; however, for those whose hearing level could not be estimated, the I component of ABR was used as the index of the stimuli intensity. In the normal aging group, the I-III inter peak latency (IPL) tended to increase in ABR, and the latency of the Po, Pa components increased in MLR. In the VD group, the I-III IPL increased significantly in ABR. In the SDAT group, the III-V IPL of leftside derivation increased in ABR, while the detectability of the Nb, Pb components decreased in MLR. SVR could not be observed in the two patients with severe SDAT. The changes in MLR accompanied by aging suggest the dysfunction of the thalamus and of the ascending reticular formation activating system, and are considered to be related to senile sleep disturbance. The increase in the I-III IPL in VD may reflect the degree of cerebral arteriosclerosis. The change in ABR in SDAT suggests that degeneration has reached the upper brain stem in the severe cases, while the change in MLR was corelated with the degree of severity of SDAT. These findings strongly suggest the possibility of clinical application of auditoryevoked potentials in the future.
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  • Nucleotide sequence analysis of MHC class II genes in autoimmune-prone (NZB×NZW) F 1 mice
    SHIGEKI OGAWA, HIROYUKI NISHIMURA
    1990 Volume 36 Issue 3 Pages 381-391
    Published: October 20, 1990
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.381
    JOURNAL FREE ACCESS
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    We previously found that the heterozygosity of the major histocompatibility complex (MHC), H-2d/H-2Z is one of the major genetic factors responsible for the development of severe autoimmune disorders characteristic of (NZB×NZW) F 1 mice. To examine the possible role of the F 1 unique MHC class II molecule, we studied the polymorphism of MHC class II genes by analyzing the nucleotide sequence of genomic DNA and cDNA clones obtained from NZW and NZB strains. The data obtained revealed that polymorphic amino-terminal region sequences of A a, A$, E a, and Eβ genes of NZW and Aβ and Eβ genes of NZB mice were identical to those of B10. PL mice (H-2u) and Balb/c (H-2d), respectively. These findings suggest that the transassociation of a and β chains of the MHC class II molecules of these different haplotypes causes the formation of the F 1 unique MHC class II molecules.
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  • Effect of testosterone replacement on bone mineral density in adolescent male hypogonadism
    OSAMU ARISAKA, ATSUTO HOSAKA, MADOKA ARISAKA, NAOTO SHIMURA, AKIFUMI T ...
    1990 Volume 36 Issue 3 Pages 402-405
    Published: October 20, 1990
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.402
    JOURNAL FREE ACCESS
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    To assess the effect of gonadal steroid replacement on bone mineral density in 10 adolescent males with osteopenia due to hypogonadism, we compared the changes in bone density in patients given testosterone (T) replacemant (n = 4) with those in patients without T replacement (n=6). Nine of the 10 patients initially had open epiphyses and received T (125mg, i.m.) every months for 12 months. Cortical bone density in the nondominant distal radius was measured by single-photon absorptiometry, which revealed that in all T-replaced patients, bone density was significantly increased (p<0.05). Among the patients without T replacement, the bone density was slightly increased in 2, but in the remaining 4, bone density did not increase. The serum osteocalcin level, measured as a biochemical marker of bone formation, was significantly increased (p<0.05) in T-replaced patients, but the corresponding change in patients without T-replacement was variable. We conclude that it is possible to increase cortical bone mineral density by testosterone replacement in men with hypogonadism, particularly those who are skeletally immature.
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