Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 23, Issue 4
Displaying 1-15 of 15 articles from this issue
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  • A Histopathological Study on Congenital Biliary Atresia
    SUSUMU WATANABE
    1977 Volume 23 Issue 4 Pages 510-534
    Published: December 10, 1977
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.23.510
    JOURNAL FREE ACCESS
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    In neonatal or early infants, obstructive jaundice is induced by congenital biliary atresia (CBA) and neonatal hepatitis (NH) which both shown similar hepatic histological features. The author demonstrated that the obvious differences of morphologic findings were present between CBA and NH. The threedimensional reconstruction by continuous serialsections of extraheptaic biliary system might contribute to clarify the pathogenesis of CBA. By this method, 35 autopsied and 78 surgical cases of CBA, 1 autopsied and 8 surgical cases of NH, and 5 autopsied and 11 surgical cases of choledochal cyst (CC) were histopathologically examined. The results obtained were as follows : 1. In CBA, proliferation of bile ducts, marked increase in fibrous tissue in the periportal area, and intraductal bile plugs were observed. In NH, giant cells were prominently observed. Those findings might suggest histopathological differences between the both diseases. 2. CBA, visible giant cell transformation 6 months after birth, ductal proliferation 2 1/2 months after birth, and fibrosis 3 1/3 months after birth were evidently observed. 3. Four cases (11 %) of the patients with CBA had one or more congenital anomalies other than hepatobiliary ones. However, there, was no correlation between the incidences of CBA and other anomalies. 4. The type of CBA examined were classified as follows : Type I : The obstruction of the common hepatic duct and the intact gallbladder and commonbile duct were observed in 7 cases. Type II : The obstruction of the common hepatic duct and common bile duct and the normal gallbladdar were found in 9 cases. Type III : The complete obstruction of extrahepatic biliary tracts was observed in 2 cases. 5. According to the reconstruction study of extrahepatic system in CBA, the inflammatory obstructive lesion was constantly detected in common hepatic duct. The main lesion in CBA should be situated on common hepatic duct and the intrahepatic changes might be the secondary lesions.
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  • Clinicopathological Studies on Gastric Carcinoma in Dogs Induced by N-Ethyl-N′-nitro-N-nitrosoguanidine (ENNG).
    TSUGUHIKO IZUMI
    1977 Volume 23 Issue 4 Pages 535-562
    Published: December 10, 1977
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.23.535
    JOURNAL FREE ACCESS
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    Gastric carcinoma of dog has been known to be frequently induced by oral administration of N-Ethyl-N′-nitro-N-nitrosoguanidine (ENNG) solution mixed with a pellet diet. In the present paper, clinicopathological findings on gastric carinomas induced by our method were described. Gastric carcinomas were developed in all of 4 mongrel and 3 beagle dogs. Early gastric carcinomas in two of the 7 dogs were found and both early and advanced gastric carcinomas were developed in the remaining 5 dogs. Numerous metastases to intraperitoneal and distant lymphonodes were also detected in 4 dogs. Liver metastases were observed in two beagle dogs. In one of them, peritonitis carcinomatosa with ascites and metastases to the lungs, heart, bones and subdermal tissue as well as the liver were found. Gastric carcinomas were frequently localized in the gastric antrum and the upper one-third of the stomach. The commonest type of carcinoma was protruded. Most of carcinomas were composed of tubular adenocarcinoma and signet-ring cell carcinoma. In the upper one-third of the stomach, most of the carcinomas were protruded with common histological type of well differentiated adenocarcinoma. On the other hand, there occured various types of protruded, flat and depressed carcinoma in the gastric antrum. Histologically, there was not any difference in incidence between well differentiated adenocarcinoma and poorly differentiated adenocarcinoma with signet-ring cell carcinoma. All of advanced gastric carcinomas were over 20mm in diameter. In mongrel dogs, most of carcinomas were well differentiated adenocarcinoma, whereas in beagle dogs the typical histological type was poorly differentiated adenocarcinoma with signet-ring cell carcinoma. In a mongrel dog, it was interesting that the histological findings suggestive of malignat change from benign hyperplastic polyp were seen in a polypoid lesion.
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  • Studies on the Orientation of the Sulfhydryl Proteins in Muscle and Nerve Fibers.
    KIMIYO KATO
    1977 Volume 23 Issue 4 Pages 563-573
    Published: December 10, 1977
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.23.563
    JOURNAL FREE ACCESS
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    The orientation of the SH-proteins in muscle and nerve tissues was analyzed by measuring the angular distribution of fluorescence depolarization of the dyes labeled on the samples, using a novel fluorescent thiol reagent, N- (1-anilinonaphthyl-4) maleimide (ANM) together with 1,8-anilinonaphthalene sulfonate (ANS) as a hydrophobic probe. 1. The fraction of the fluorescence intensity of the oriented components, orientation ratio (Ro), was approximately 20% in ANM-labeled samples and 17% in ANS-labeled ones regardless of the kind of samples ; rabbit muscle fiber bundles, glycerinated muscle fibers, frog sartorius muscles and frog N. ishiadicus. When the samples were dried on air, the values increased slightly in ANM-labeled samples and considerably in ANS-labeled ones. 2. The Ro values of muscle fibers was slightly elevated by soaking in glycerine at -20°C, for several months, while that of fresh ANM-stained fibers increased after one day and then decreased by the same treatment. Fresh frog nerve was not stained by ANS, but an oriented fraction of about 7% appeared after glycerination. The fraction further increased by drying. The Ro values of ANM-labeled muscle fibers increased until 60 sec after the addition of trypsin and then decreased. 3. No oriented fraction was observed in the ventral cord of Cambaras clarkii. 4. All of the samples showed symmetrical biaxial orientation which was parallel and perpendicular with the axis of the fibers. This mode was not essentially altered by drying. 5. In the most of the fresh samples, the parpendicular fraction was larger than the parallel one. The difference between the two fractions increased by drying, while it decreased by the treatment with glycerine. The present experimental results clearly show that a part of the SH-proteins is oriented on the surface of these fibers.
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