Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
Search
Advanced search
OR
Browse
Search
Volume 29, Issue 4
Displaying 1-17 of 17 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
Contents
  • A Clinical Study on the Influence of Alcohol Intake on Ischemic Heart Disease (IHD) and Myocardial Disease
    YAMATO NAKAJIMA
    1983 Volume 29 Issue 4 Pages 519-531
    Published: December 10, 1983
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.29.519
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    To detect the influence of alcohol intake on heart disease, 378 cases of acute myocardial infarction (AMI) in Juntendo University Hospital and 66 cases in Koshigaya City Hospital were reviewed. One hundred and fifty-two cases of myocardial disease and 64 autopsied cases of myocardial disease were also studied. Clinical examination data of 107 cases of chronic alcoholism and 53 cases of alcoholic hepatic disease were analyzed. The results were as follows. 1) In Japan, alcohol consumption and IHD have increased in recent years. 2) In the past, many patients with AMI were abstainers, while drinkers with AMI have not been rare in the last few years. 3) In this study, it was not concluded that alchol consumption was a negative risk factor in IHD. In 10 to 13% of cases with AMI, a history of alcohol intake following the heart attack was detected. 4) Electrocardiographic abnormality and cardiomegaly were common in patients with chronic alcoholism and alcoholic hepatic disease. 5) In an echocardiographic study of 25 cases of chronic alcoholism, three showed a decreased ejection fraction and four cases also showed a decrease of mean velocity of circumferential fiber shortening (mVCF). The impairment of LV function in these cases may suggest that habitual heavy drinking reduces the systolic LV function. 6) In our 152 cases of myocardial disease, 15 were diagnosed as alcoholic heart disease because of their habitual heavy drinking. 7) Six cases of alcoholic heart disease were autopsied. Macroscopic examination showed increased heart weight and marked dilatation of the left ventricle. Microscopic examination revealed myocardial hypertrophy, degeneration and intramyocardial fibrosis.
    View full abstract
    Download PDF (3699K)
  • Pathological and Clinical Study of Pancreatic Carcinoma
    MASATAKA SUMIDA
    1983 Volume 29 Issue 4 Pages 532-549
    Published: December 10, 1983
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.29.532
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    This report compares pathological and clinical findings in pancreatic carcinoma and assesses diagnostic modalities for this condition in order to provide a data base for their rational use especially in the diagnosis of small resectable tumors. One hundred and twenty-two patients with proven pancreatic carcinoma have been studied during the period between 1972 and 1982. Angiographic findings in pancreatic carcinoma were pathologically analyzed. The radiographic appearance of arterial encasement reflects arterial narrowing due to fibrosis from the presence of malignant cells around the vessel wall, with intimal proliferation as a secondary response producing additional narrowing and irregularity of the lumen. In arterial occlusion, the lumen is still patent, but is considerably narrowed with intimal proliferation secondary to the gross reduction in caliber of the vessel. Comparative study of macroscopic and angiographic findings revealed that angiography accurately defines tumor size. Invasion of carcinoma into the surrounding tissue can also be diagnosed with angiography. However, pancreatic capsule invasion was difficult to assess. A prospective comparison of sensitivity, specificity and predictive value of ultrasonography (US), computed tomography (CT), endoscopic retrograde cholangiopancreatography (ERCP) and angiography was performed. ERCP had the highest sensitivity and specificity in evaluation of pancreatic carcinoma. CT was the least sensitive in detecting pancreatic malignancy. Positive predictive value was the highest in angiography, while negative predictive value was high in US and ERCP. A diagnosis of unresectable pancreatic carcinoma could be made by US and CT without need for additional imaging procedures. ERCP can show very small tumors, even when the size of the gland is normal. Angiography is a complementary examination to ERCP to determine whether the lesion is benign or malignant, and, if malignant, whether it is resectable or not.
    View full abstract
    Download PDF (2720K)
  • Immunohistochemical and Histopathological Studies on the Changes of Pancreatic Islet Cells in Chronic Pancreatitis
    ICHIRO KONUMA
    1983 Volume 29 Issue 4 Pages 550-560
    Published: December 10, 1983
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.29.550
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    To investigate the changes of pancreatic islet cells in chronic pancreatitis, immunohistochemical quantitation of the distribution of insulin (B), glucagon (A), somatostatin (D) and pancreatic polypeptide (PP) producing cells was performed with the pancreatic tissues removed from patients with severe chronic pancreatitis and nonpancreatitic controls. In chronic pancreatitis, as compared to the controls, there were a significant increase in the proportion of A, D and PP cells and a decrease in the proportion of B cells in the pancreatic islets distributed in the parenchymal tissues. In the fibrotic tissues, on the other hand, two distinct types of islets were found. One was rather large and rich in the number of islet cells. The proportion of each endocrine cell was similar to that found in the islets in the parenchyma. The other was small and irregular in shape and was associated with a decrease of islet cells. Such a type of islet was predominantly composed of B cells. Together with the histopathological finding of the presence of ductuloinsular proliferation, it was suggested that the latter type of islets is under regeneration.
    View full abstract
    Download PDF (3847K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top