Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 5, Issue 2
Displaying 1-12 of 12 articles from this issue
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  • Essai de la prochlorperazine en clinique
    Michitaka HIROSAWA, Takao ISHIZAKI, Shohei YAMAGUCHI, Isao OKADA, Yosh ...
    1959 Volume 5 Issue 2 Pages 95-100
    Published: April 10, 1959
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.5.95
    JOURNAL FREE ACCESS
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    Un nouveau dérivé de la phénothiazine, la prochlorpérazine, a été expérimenté sur un total 44 cas, et s'est révélé particulièrement efficace dans les états hypothymiques de la schizophrénie (environ 47%) et dans les états dépressifs (environ 17%) qui n'avaient que peu réagi à d'autres médicaments. Lts doses quotidiennes ont varié de 15 à 100mg per os, mais dont la pluspart a été au-doussous de 40mg à cause des effets secondaires de ce produitl lls ont correspondu à peu prés. au syndrome excito-moteur de J. Delay. Ce médicament, à notre avis, comble bien l'imperfection de l'efficacité des tranquillisants dans les états hypothymiques et dépressifs.
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  • Discharge Patterns of Spinal Element in Strychnine Tetanus
    Ayako ISHIDA, Seiji TANAKA
    1959 Volume 5 Issue 2 Pages 101-108
    Published: April 10, 1959
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.5.101
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    1. The discharge patterns of some units (neuron or neuron group) in strychnized spinal cord of the frog are investigated. The lead-off electrode was made of glass capillary in which a small silver Wire (less than 10μ) Was inserted until the tip. The diameter of the capillary was less than 20μ at the tip. 2. When the electrode is inserted in spinal cord, the firing of a single spinal unit is usually seen probably by the mechanical penetration, but it does not develop to a typical strychnine spasm. 3. During the strychnine spasm most of the units discharged synchronously with the same rhythm as the spasm, but some uuits discharged even in the resting period, in which no discharge was observed at the peripheral nerves or muscles. 4. By the simultaneous recording from two positions in spinal cord, it was observed that there are not only synchronized units but also asynchronized units in the strychnized spinal cord. 5. The discharge frequency observed in strychnized spinal unit was usually twice as high as that in nonstrychnized unit (50c/sec). The firing frequency during the strychnine spasm. increased to about 140c/sec, which was higher than the frequency of discharge elicited by mechanical penetration of the electrode. 6. It was proposed that in the process of strychnine tetanus there are at least two types of unit (neuron gpoup) in the spinal cord, and that one has an excitatory effect and the other has an inhibitory effect on motoneurones. For the formation of the discharge pattern of strychnine spasm the coordination of these two units would play the important roll, especially the activity of inhibitory units may result in the silent period between discharge groups.
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  • Studies on the Classification of the Genus Saccharomy es
    I. Antigenic Structures of four Species of the Genus Saccharomyces
    Yoshiwo SHIMURA
    1959 Volume 5 Issue 2 Pages 109-117
    Published: April 10, 1959
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.5.109
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    The authentic strains of the four species of the genus Saccharomyces such as S. mellis, S. pastorianus S. oviformis and S. chevalieri, were used for antigen analyses by means of slide agglutination method with monospecific or absorbed antisera homologous to antigens of the genus Candida. Then antiserum of a species was absorbed repeatedly with heated cells of several species of the genera Candida and Saccharomyces in order to find a new antigen until the absorbed antiserum was exhausted. Antigenic structures of the species were confirmed by the reciprocal absorption method. S. mellis has thermostable antigens 1, 8, 10, 31 and 32, S. pastoriarus has antigens 1, 8, 10 and 32, S. oviformis has antigens 1, 2, 3, 10, 14, 18 and 31, and S. chevalieri has antigens 1, 2, 3, 8, 10, 14, 18 and 31. But every species does not have any thermolabile antigen. Consequently, the first two species show almost the same to the antigenic structure of Candida pseudotropicalis, and the antigenic structure of S. oviformis isidentical to that of S.uvarum.
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  • Significance of Coagulase and Fermentation Reactions in the Classification of Staphylococcus
    Yoshimura FUKAZAWA, Yukio NISHIKAWA, Minoru YONEZAWA, Tatuo KOBAYASHI, ...
    1959 Volume 5 Issue 2 Pages 118-124
    Published: April 10, 1959
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.5.118
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    The authors studied the relationship between the coagulase test and the other biological characteristics of many strains of Staphylococcus. The pigmentation, fermentation, hemotoxin production and agglutination reaction were examined. Results obtained as follows : 1) All the strains of the species Staphylococcus which was defined by the coagulase test, corresponded completely with the fermentation reactions using sixteen sugars. 2) In the fermentation, a number of sugars for the classification of Staphylococcus can be limitted to only six sugars, such as mannit, lactose, galactose, xylose, arabinose and raffinose. 3) The coagulase test and fermentation should be performed in the accurate identification of Staphylococcus. Moreover, the authors consider that the coagulase test will serve as a reliable basis for the classification of the species Staphylococcus, since fermentation reactions of sugars coincided with the coagulase reactions.
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  • Studies on the Antigens of the Genus Hansenula
    Yukio NISHIKAWA
    1959 Volume 5 Issue 2 Pages 125-131
    Published: April 10, 1959
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.5.125
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    In my previous report and Amemiya's report, the antigenic structures of several species of the genus Hansenula were indicated through antigen analyses. The standard strains used for antigen analyses were authentic, but the antigenic structure of one species was derived from the single strain. Therefore, fifty stock cultures other than the standard strains were collected for my comparative study. Biological characteristics of the stock cultures were examined again by the usual method, and then an existence of antigens of every strain was examined by the slide agglutination method with monospecific or absorbed antisera based on the antigenic structures of the genera Candida and Hansenula. Both identifications correspond each other. Consequently, the antigenic structures, will be serve as the reliable basis of the classification of the genus Hansenula.
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  • Studies on the Antigens of the Genus Schwannionyces
    Ichiro SATO, Yabunji SANO, Mitsuru TAKAHASHI, Minoru YONEZAWA, Tatsuo ...
    1959 Volume 5 Issue 2 Pages 132-137
    Published: April 10, 1959
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.5.132
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    The genus Schwanniomyces includes only one species : Sw. occidentalis. The spores are round or oval, warty, with a ledge. The authentic strain of the species was used for antigen analysis by slide agglutination method with monospecific or absorbed antisera homologous to antigens of the genus Candida. Heated organisms of the species showed positive agglutination reactions against monospecific or absorbed antisera homologous to antigens 2, 3, 4, 9 and 14. The antigenic structure of the species was confirmed by the reciprocal or successive absorption method. Moreover, the formolized Sw. occidentalis antiserum absorbed with heated organisms of the same species showed positive reaction against live organisms of the same species alone. Therefore, it was concluded that Sw. occidentalis has thermostable antigens 1, 2, 3, 4, 9 and 14, and thermolabile antigen j.
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  • Studies on the Intestinal Movement of Sensitized Rabbit (1)
    Shimpei ARAI
    1959 Volume 5 Issue 2 Pages 138-146
    Published: April 10, 1959
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.5.138
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    The intestinal movement, when incurred, was observed through the abdominal window of the rabbit sensitized with egg-white albumin or horse serum. Simultaneously, the supersensitiveness of the excised intestine and the fluctuation in the blood antibody level was investigated. The following results were thus obtained. 1. The intestinal movement in vivo at the time when the corresponding antigen was given again parentally to the parentally sensitized rabbit was found accelerated and the degree of the acceleration was considered roughly in parallel with the blood antibody level. 2. An accelerated intestinal movement was observed also when the corresponding antigen was given again orally to the parentally sensitized rabbit. 3. In some cases of orally sensitized rabbits, acceleration in vivo was observed when orally incurred, but not in some other cases. 4. When parentally incurred a remarkable lowering in the blood antibody level was observed, but, when orally incurred, no fluctuation in the blood antibody level was recognized. 5. When incurred, the acceleration of the intestinal movement and the intestinal hyperemia were caused rouguly in parallel. 6. No significant difference in the pattern of the establishment of sensitization according to antigens was noted
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  • Studies on the Intestinal Movement of Sensitized Rabbit (2)
    Shimpei ARAI
    1959 Volume 5 Issue 2 Pages 147-152
    Published: April 10, 1959
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.5.147
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    The intestinal movement, when incurred, was observed through the abdominal window of the rabbit sensitized with mucus membrane of rabbit. The following results were thus obtained 1. The intestinal movement in vivo at the time when the same extract was given again to the parentally and orally sensitized rabbit was found accelerated, and the intestinal hyperaemia was marked generally. 2. The degree of the acceleration of the intestinal movement, when incurred, was more marked on the orally sensitized rabbit than that of the parentally sensitized one. 3. The antibody level in the blood was negative without distinction of the method of sensitization.
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  • Studies on the Effect of the Convulsion on the Movements of Intestinal Canal
    Shimpei ARAI
    1959 Volume 5 Issue 2 Pages 153-162
    Published: April 10, 1959
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.5.153
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    The convulsion of the rabbit was induced by an injection of convulsion's toxin, and the intestinal movements were observed through the abdominal window. The results were as follows. 1. The intestinal movements in vivo were completely stopped at the time when the convulsion occurred, and the blood vessels of the intestine schowed severe anemia. 2. In the case of the splanchnicectomized rabbit the intestinal movement was promoted after the convulsion, but there was no promotion of intestinal movement in the vagotomized one. 3. There was no significant difference in the dosage which induced the convulsion both in the normal rabbit and the autonomic neurectomized one. 4. It seems that the intestinal movement is controlled by the autonomic nerves and that the variation of the intestinal circulation has a great effect upon it.
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