Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 19, Issue 2
Displaying 1-17 of 17 articles from this issue
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  • Occurence of Lymphogenic Metastasis of Gastric Cancer
    -On the Special References to the Early Carcinoma of the Stomach-
    HIROYUKI TAZAKI
    1973 Volume 19 Issue 2 Pages 219-238
    Published: June 10, 1973
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.19.219
    JOURNAL FREE ACCESS
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    Sixty five cases of the early gastric carcinoma, diagnosed and treated in our clinic from May 1967 to April 1970, were studied as to the clinical picture, pathological findings of the resected stomach, especially on the presence of lymph-vascular invasion of the gastric wall, histological classification of the degree of the removed lymph nodes metastasis, and so on. In an analysis of 65 cases of the early gastric carcinoma, 32 cases were the carcinoma of the stomach of which invasion was limited to the mucosa (m), and 33 cases were of the submucosal (sm) layer An average of 16 nodes per patient was obtained at operation and the metastasis into regional lymph nodes was observed in nine patients (13.8%), in whom 7 patients cancer already infilted into the submucosal layer (21.2%). One patient had the metastasis to the removal lymph nodes of group 2, and another one had the metastasis to infrapyloric lymph node (No. 6) and to lymph node at root of the mesenterium (No. 14) : so-called Jumping Metastasis. On examining the invasion to lymph channels of the gastric wall, it was proved that lymphogenic metastasis was found in sixteen patients (48.5%) with “sm” cancer but negative with “m” cancer. No significant difference was found in sex, age, histological type, extent of cancer and its location, size and solidity of the removed lymph node between cases with vascular invasion and lymph nodes metastasis and without ones lymph node metastasis. The cases with lymph-vascular invasion following were found in IIa group (IIa, IIa+IIc type) remarkably more than in IIc type in macroscopic classification. This fact suggested that the occurrence of metastasis might be associated with the essential characteristic of the gastric carcinoma. According to these results, the author would also emphasize that it is necessary to perform the R2 procedure in the operation of gastric cancer to remove the regional lymph nodes.
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  • The Comparison of Therapeutic Effects of FK-880 (Sulpiride) and Perphenazine in Schizophrenia by A Double-blind Controlled Study
    TAIRIKU AMAKUSA, TAKEJIRO MAJIMA
    1973 Volume 19 Issue 2 Pages 239-249
    Published: June 10, 1973
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.19.239
    JOURNAL FREE ACCESS
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    The authors carried out a pilot study on therapeutic effectiveness of sulpiride mainly in the treatment of schizophrenia. The results of this study were already published (Journal of New Remedies & Clinics 22 ; 29, 1973). This paper presents the effect of sulpiride on schizophrenia by a double-blind controlled study compared with perphenazine, an established standard neuroleptic. The subjects enrolled were 64 hospitalized chronic schizophrenics, who were divided into two groups and daily given4-10 tablets of either sulpiride (100mg/Tab.) or perphenazine (3mg/Tab.) for a period of 6 weeks. During this period, 9 patients, 5 receiving sulpiride and 4 receiving perphenazine, dropped out. The global comparative judgement after the treatment for 6 weeks revealed statistically no significant difference in the therapeutic effects between both drug groups by a sequential analysis. The general improvement rating after the treatment for 6 weeks revealed that the slight or more improvement was observed in 44.4% of patients given sulpiride and 55.2% of patients given perphenazine, while the moderate or more improvement was observed in 29.6% and 13.8%, respectively. In patients suffering from schizophrenia for over 5 years, sulpiride showed significantly more favourable effect than perphenazine (P<0.05). This result suggests that sulpiride could be also favourably effective in the treatment of chronic schizophrenia. In the items of the three universities' rating scale, perphenazine made significantly higher improvement in hallucination than sulpiride (P<0.05) 4 and 6 weeks after initiation of the treatment. In the incidence of side effects, no significant difference was observed between the two groups. In the laboratory tests performed in all the patients no contributory abnormal findings were obtained.
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  • Pancreatographical and Histopathological Study of Dilations of the Pancreatic Ductules
    -With Special References to Cystic Dilatations-
    KATSUHIKO KOMATSU
    1973 Volume 19 Issue 2 Pages 250-269
    Published: June 10, 1973
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.19.250
    JOURNAL FREE ACCESS
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    1. Cystic dilatations of pancreatic ductules were recognized in 37 cases of the random selected 85 autopsy cases. 2. Cystic dilatations show tendency to appear in multiple locations in pancreas. The small dilatations are round or oval shaped, the larger dilatations are tend to show irregular shapes. 3. The observed frequency of cystic dilatations showed a certain increase in proportion with the aging. 4. In cases of the subsistence of accessory pancreatic ducts, cystic dilatations are observed smaller in number. 5_Cystic dilatations are considered deeply concerning with the running pattern of the pancreatic ducts. 6. The diameter of main pancreatic duct is increased with the aging, both on X-ray films examination (at the largest diameter) and on histological sections. 7. Cystic dilatations has any relationship neither associated disease, nor pancreatic weight and sex differences. 8. Cystic dilatations of pancreatic ductules tend to appear just below the pancreatic surfaces. That pancreatic tissue supposed to show a loss of tension, due to atrophy and dissapearance of pancreatic parenchyma and also due to the viscid mucus production and retention from the goblet cell metaplasia. Frequently, ductal epithelial proliferations are seen in association with the goblet cell metaplasia, are also seen cases of hyperplasia of ductal epithelium. Concerning etiological relationship of cystic dilatations, the author is considering these may due to the chronic pancreatitis.
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