Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
Search
Advanced search
OR
Browse
Search
Volume 50, Issue 2
Displaying 1-14 of 14 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
Contents
  • On calcium current of cardiac plasma membrane
    RIKUO OCHI
    2004 Volume 50 Issue 2 Pages 112-123
    Published: June 30, 2004
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.50.112
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Calcium currents of the cardiac plasma membrane were first found as slow inward currents (Is) in multi-cellular preparations using the sucrose-gap voltage clamp method. I published the properties of Is and novel Mn current in guinea pig papillary muscle from W Trautwein's laboratory in Heidelberg (1970). Whole-cell Mn current flowed through the L-type Ca channel with a density of 8% of Ca current. Reevaluation of the trigger action versus the membrane potential relationship in Heidelberg suggests that Is is responsible for the trigger action, as expected from CICR. Is was inhibited by acetylcholine and gentamicin. A single Ca channel study demonstrated the following : 1) BAY K 8644 greatly prolonged the open time of the Ca channel, 2) nitrendipine (NIT) decreased the channel availability (Ps), 3) isoproterenol (ISO) prolonged the non-blank run (S-state) and shortened blank run (F state) to increase Ps, 4) adenosine decreased Ps in the presence of ISO, and 5) Ps was increased by 5-HT in human atrial myocytes. A whole-cell clamp study demonstrated the following : 1) the independent modulation of L-type channel currents by ISO and NIT, 2) currents by extrinsic expression of α1E subunit to cultured adult rabbit ventricular myocytes, 3) L-type Ca channels in hepatic satellite cells, and 4) epiandrosteroneinduced blockade of L-type Ca channel current. I consider our most valuable work to be the single channel analysis of the mechanism of sympathetic regulation of cardiac L-type Ca channels.
    View full abstract
    Download PDF (1546K)
  • Annual change and present status of antimicrobial-resistant strains isolated from clinical speciment in Juntendo University Hospital
    JUN IGARI
    2004 Volume 50 Issue 2 Pages 124-132
    Published: June 30, 2004
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.50.124
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    This paper reviews the recent emergence and prevalence of penicillin-resistant S. pneumoniae, ampicillin-resistant H. influenzae, extended-spectrum β-lactamases-producing Gram-negative rods and metallo-β-lactamase-producing Gram-negative rods at Juntendo University Hospital. 1. Penicillin-resistant S. pneumoniae (PRSP) emerged in 1980 at Juntendo University Hospital. The rates of PRSP and PISP increased substantially from 13.3% in 1990 to 59.8% in 2003. Most strains of PRSP were also resistant to TC, CP, EM and second and third-generation cephalosporins. A vancomycin-resistant strain has not been isolated. 2. The rate of β-lactamase-positive ampicillin-resistant (BLPAR) H. influenzae was 29 to 31% from 1990 to 1992, subsequently, annual rates have flucutuated, stabilizing at 10 to 16% around 2000. From 2001 to 2003, rates fell to 7 to 6.4%. On the other hand, rates of β-lactamasenegative ampicillin-resistant (BLNAR) strains were 1 to 4% from 1991 to 1999, subsequently, there was a gradual increase from 7 to 11% by 2001, but the incidence increased repidly to 33.1% in 2003 and 41.9% in 2003, BLNAR strains showed high rates of resistance to oral cephalosporins. 3. Extended-spectrum β-lactamase (ESBL) -producing E, coli emerged in the early (1990s) in this hospital. Rates of ESBL producing E, coli were 5.6 to 5.2% from 1994 to 1996 and 7.3 to 8.8% from 2000 to 2001. ESBLs producing strain of E, coli and K pneumoniae isolated from 1995 to 2001 showed high rates of resistance to CTX, CPDX, AZT, CTM, CDTR and CFPM. 4. Among metallo-β-lactamase-producing Gramnegative rods, P. aeruginosa and Serratia are frequenlly isolated in this hospital. The rate was 1.3% in 2002.
    View full abstract
    Download PDF (1423K)
  • Introduction of Rehabilitation Medicine
    MASANORI NAGAOKA
    2004 Volume 50 Issue 2 Pages 133-146
    Published: June 30, 2004
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.50.133
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    In this article, I have tried to explain what rehabilitation means and what ought to precede it. First, to promote understanding, one imaginary stroke patient was presented and his possible problems from admission to an acute hospital to his reinstatement at his former place of work were discussed. Rehabilitation is considered to be the process of helping a person to reach the fullest physical, psychological, social, vocational, avocational, and educational potential consistent with his or her physiologic or anatomic impairment, environmental limitations, desires and life plans. These days, although it began as a discussion of the possibility of re-acquisition of losses due to advances in technology, the process of rehabilitation is fundamental and is required by every patient. As a patient care team, many specialities are involved and the knowledge of medicine is indispensable at all stages of rehabilitation. The difference between the medical model and disability model was explained. Particularly, the latter is useful for training in rehabilitation medicine. Because rehabilitation medicine and its philosophy is strongly related to humans as independent social-beings, it should be stressed that the knowledge and techniques of rehabilitation should be related and influential to the many clinical departments of Juntendo university that see these patients. Because of the limited period of admission, as long as 15 days on average, we can not accomplish the goal of independent living sometimes. In this situation, our hospital should collaborate with other related hospitals and different disciplines. “The continuum of service from Juntendo hospital to society” is one of our objects.
    View full abstract
    Download PDF (2859K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top