Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 43, Issue 1
Displaying 1-25 of 25 articles from this issue
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Contents
  • Effects of endothelin-1 on phosphate transport in the brush border membrane vesicles (BBMV)
    MIKI TAKIZAWA-SHIMADA
    1997 Volume 43 Issue 1 Pages 65-70
    Published: July 10, 1997
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.43.65
    JOURNAL FREE ACCESS
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    Endothelin (ET) is the most potent vasoconstrictive agent released from endothelial cells and many other types of cells. Endothelin has physiological effects on the rat kidney, especially on the renal proximal tubules. The role of endothelin-1 in the renal brush border membrane (BBM) was examined. The Vmax of Pi uptake by brush border membrane vesicles (BBMV) in the endothelin-1 treated group was significantly higher than that in the control group. There were no significant changes in apparent Km values between the two groups. These findings suggested the presence of endothelin-1 receptor in the proximal tubules. Administration of endothelin-1 might increase the Pi reabsorption by BBMV by changing the capacity of the transporter.
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  • Clinical and electroencephalographic studies on the soft pattern
    DEYING LI, SHIGEKO SHINOMIYA
    1997 Volume 43 Issue 1 Pages 71-77
    Published: July 10, 1997
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.43.71
    JOURNAL FREE ACCESS
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    We report the incidence and clinical role, of the soft pattern on EEG. The soft pattern consists of high voltage α wave bursts which are clearly distinguishable from the background activity. However, it has never been clearly defined. In this study, we examined, the soft pattern as α wave bursts which are clearly distinguishable from the background activity by their frequency (slower than that of the background) and/or amplitude (higher than the background). Among the 5,292 patients who received EEG examination, 44 patients (0.83%) showed the soft pattern. A female preponderance was noted, the male to female ratio being approximately 1 : 2. The soft pattern was most frequently seen in patients between 41 and 60 years and patients over 81 years of age. Although no clinical syndrome which is specific to the presence of soft pattern was noted, dysrhythmic background EEG activity was seen in 77.3% of the patients who showed the soft pattern, and the diffuse α pattern in 44.4%. In addition, 14 of those 44 patients were taking anticonvulsant drugs, and 11 were taking sodium valproate. Therefore, the soft pattern appears to represent a state of suppressed cerebral activities.
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  • Measurement of the cross-sectional area of the dural tube in the lumbar spine on magnetic resonance imaging-Comparison between normal, pre-and post-discectomy conditions
    YASUTOMO MATSUBAYASHI
    1997 Volume 43 Issue 1 Pages 78-84
    Published: July 10, 1997
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.43.78
    JOURNAL FREE ACCESS
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    Objective This study evaluated the usefulness of pre-and postoperative magnetic resonance imaging (MRI) of lumbar disc hernia with special attention to measurement of the cross-sectional area of the dural tube. Materials and methods Twenty-five patients (20 men and 5 women; 25 discs) who underwent posterior lumbar discectomy and 73 normal individuals (44 men and 29 women; 219 discs) of a similar age distribution were studied. Axial MRI was mainly used for the measurement of the dural tube. In the patient group, MRI examination was performed 1, 3, 6, and 12 months postoperatively. Assessment of the clinical symptoms was also included and used for comparison with the MRI evaluation. Results The cross-sectional area was significantly reduced to about 50% of the normal preoperatively. One month postoperatively, there was no significant increase in the size of the area, but after three months, the area increased significantly and progressed to the normal size within a year. One-month postoperatively, MRI examination was not considered useful because of postoperative hematoma and/or edema at the surgical site. The increase in the size of the cross-sectional area of the dural tube correlated well with the improvement in clinical symptoms. Conclusion Three-months postoperatively, MRI evaluation of the lumbar disc seemed useful and measurement of the cross-sectional area of the dural tube appeared to serve as an indicator of the effectiveness of the surgery.
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  • Activated CD4+T cell subpopulations in murine lupus detected by monoclonal antibodies to distinct early activation antigens
    SHIN AKAKURA, HIROYUKI NISHIMURA, SUSUMU HATTORI, SHO ISHIKAWA, HIROMI ...
    1997 Volume 43 Issue 1 Pages 85-97
    Published: July 10, 1997
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.43.85
    JOURNAL FREE ACCESS
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    High frequencies of CD 4 +T cells bearing activation antigens such as HLA-DR and-DP in the blood of patients with systemic lupus erythematosus (SLE) suggest that a continuous activation of autoreactive CD 4 +T cells occurs in this disease condition. In the present studies, we analyzed spontaneously activated CD 4 +T cells in the spleens of SLE-prone NZB and (NZB × NZW) F 1 mice, using two distinct early T cell activation markers, CD69 and NTA204. A marked age-associated increase in the proportion of both CD69+ and NTA204+ activated CD4 +T cells was observed in NZB and (NZB × NZW) F 1, but not in nonautoimmune NZW and BALB/c mice. Interestingly, there were three phenotypically separate types of activated T cells; one activated by CD69 alone, one by NTA204 alone, and one by both CD69 and NTA204. Studies of T cell receptor (TCR) V beta repertoire showed that these activated T cells had no skewed TCR V beta repertoire usages. Murine CD 4 +T cells could be subdivided into 4 distinct subsets, either positive or negative for CD62L (L-selectin) and NTA260, an antigen detected by a hybridoma monoclonal autoantibody from autoimmune NZB mice. It was found that all three activated CD 4+T cell subpopulations were included in the CD62L-NTA260-CD 4 +T cell subset. This subset was unique because it belonged to neither naive nor memory CD 4 +T cells. It also did not function as either Th 1 or Th 2, based on its cytokine production patterns. As such CD62L- NTA260- CD 4 +T cell subset became the major population of CD 4 +T cells in aged NZB and (NZB × NZW) F 1 mice, further phenotypical and fuctional analyses of this subset may provide insights into the mechanisms of the generation of autoreactive T cells responsible for the pathogenesis of SLE.
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