Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 46, Issue 1
Displaying 1-26 of 26 articles from this issue
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Contents
  • Characterization of lipoproteins containing apolipoprotein B-100 in remnant-like particles (RLP) and its association with coronary artery disease (CAD
    YASUTERU USUKI, HIROSHI MOKUNO
    2000 Volume 46 Issue 1 Pages 48-61
    Published: June 26, 2000
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.46.48
    JOURNAL FREE ACCESS
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    Objective : RLP were defined as unbound fractions from immunoaffinity gels containing monoclonal antibodies against apolipoprotein (apo) A-I and B-100, and may reflect atherogenic triglyceride-rich remnant lipoproteins. However, RLP are heterogeneous lipoproteins composed of exogenous lipoproteins containing apoB-48 and endogenous lipoproteins containing apoB-100. To evaluate endogenous lipoproteins containing apoB-100 in RLP, we developed a new enzyme-linked immunosorbent assay (ELISA) for the specific detection of apoB-100 in RLP (RLP-apoB100), and clarified the distribution of RLP-apoB100 in lipoproteins and the association of RLP-apoB100 with CAD. Materials and methods : Subjects consisted of 2 normolipidemic individuals and 3 hyperlipidemic individuals. Distribution of RLP-apoB100 was examined in lipoprotein fractions separated by ultracentrifugation for density or gel chromatography for particle size. In one subject, distribution of RLP-apoE was examined by ELISA and electrophoresis of these fractions. To investigate its atherogenic role, plasma lipids and RLP-apoB100 were compared between 20 healthy control subjects, 8 CAD (-) patients and 42 CAD (+) patients who had undergone coronary angiography. CAD (+) was defined as ?50% stenosis in major coronary arteries. Results : RLP-apoB100 was distributed in only buoyant LDL of control subjects. In contrast, it was widely distributed in VLDL, IDL and small, dense LDL of hyperlipidemic subjects. In type III hyperlipidemic subjects, RLP-apoE was also distributed in VLDL, IDL and LDL. In clinical analysis, levels of RLP-apoB100 were the lowest in control subjects and the highest in the CAD (+) patients. CAD (-) patients' levels were between those of control subjects and CAD (+) patients (6.8 vs 10.4 vs 12.2 mg/dl, p<0.001). Conclusion : The measurement of RLP-apoB100 can evaluate endogenous lipoproteins in RLP, which may contribute to atherogenicity of RLP.
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  • Long term follow-up of sick sinus syndrome with atrial pacing
    SHUNSUKE OGURA
    2000 Volume 46 Issue 1 Pages 62-70
    Published: June 26, 2000
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.46.62
    JOURNAL FREE ACCESS
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    Objective : Atrial pacing, despite its beneficial hemodynamic and antiarrhythmic effects, is still underestimated as a mode of choice for the treatment of patients with sick sinus syndrome (SSS). Main purposes of this study were to evaluate long-term outcomes of the pacing modes on SSS and the electrical stability of the atrial myocardium. Patients : One hundred thirty-three patients with SSS treated with pacemaker therapy at Juntendo University Hospital between 1980 and 1995 were followed for a median period of 74 months. Sixty-four patients underwent atrial pacing mode with AAI pacemaker, and 69 did ventricular pacing mode with a VVI pacemaker. Atrial pacing was performed using a lead of active fixation type. Methods : As pacing parameters of the atrium, pacing threshold, P-wave amplitude and impedance were assessed. These parameters were compared between 64 SSS patients with AAI pacemakers and 109 atrioventricular (AV) block patients with DDD pacemakers. Measurement and Results : The intrinsic P-wave amplitude and pacing threshold were found to be constant during the long term follow-up period. No SSS patients with atrial pacing developed advanced AV block. Six (9%) of 64 SSS patients with atrial pacing and 22 (32%) of 69 SSS patients with ventricular pacing developed atrial fibrillation. Electrophysiological characteristics of the group complicated with chronic atrial fibrillation revealed slight prolongation of the atrial refractory period. The pacing parameters of the atrium showed no difference between 64 SSS patients with atrial pacing mode and 109 AV block patients with DDD pacing mode. Conclusions : Atrial pacing is proved to be a safe and reliable treatment for SSS.
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  • CCR4 and CCR5 as amarker of Th2 and Th1 Cells in human peripheral blood lymphocytes
    TAKESHI TAKANASHI, HIRONORI MATSUDA, HIDEO YAGITA, KO OKUMURA
    2000 Volume 46 Issue 1 Pages 71-77
    Published: June 26, 2000
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.46.71
    JOURNAL FREE ACCESS
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    Chemokine receptors play important roles in controlling the migration of lymphocytes to lymphoid and non-lymphoid tissues. Recent studies have shown that CCR4 is preferentially expressed on type 2 helper T (Th2) cell lines producing interleukin-4 (IL-4) and IL-13, and CCR5 is expressed on type 1 helper T (Th1) cell lines producing interferon-γ (IFN-γ). In this study, we investigated how CCR4 and CCR5 are expressed on peripheral blood T lymphocytes from 33 healthy individuals. CCR4 and CCR5 marked two distinct subsets of memory T lymphocytes expressing CD45RO in a mutually exclusive manner. Among CD4+ memory T lymphocytes, 10-20% expressed CCR4 but not CCR5 and 15-25% expressed CCR5 but not CCR4. In contrast, the majority (50-70%) of CD8+ memory T lymphocytes expressed CCR5 but not CCR4. After in vitro stimulation, CCR4+ cells isolated from memory T lymphocytes predominantly contained IL-4-producing cells (15%) over IFN-γ-producing cells (2%) and, conversely, CCR5+cells predominantly contained IFN-γ-producing cells (60%) but only a few IL-4-producing cells (3%). These results indicated that CCR4 and CCR5 can be useful surface markers of Th2 and Th1 cells in human peripheral blood T lymphocytes.
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  • Reflux esophagitis caused by Ca antagonist in the elderly
    KOH MORICHIKA, TAKAYUKI HASHIMOTO, MASAKO KUSANO, KUNIAKI INAMI, TAKAO ...
    2000 Volume 46 Issue 1 Pages 78-83
    Published: June 26, 2000
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.46.78
    JOURNAL FREE ACCESS
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    Objective : A gastroesophageal reflux of contrast medium was useful in diagnosing reflux esophagitis radiologically. The aim of this study was to investigate the prevalence of reflux esophagitis caused by Ca antagonists in elderly subjects. Participants : Three hundred sixty-one adults and 190 elderly subjects were investigated. Of those, 31 adults and 45 elderly subjects receiving a Ca antagonist were studied. Methods : A gastroesophageal reflux was used to obtain a double contrast figure in the supine position and a filling figure in the prone position radiologically. Reflux esophagitis was evaluated by the Los Angeles classification by endoscopy. Results : The prevalence of reflux esophagitis was 12.2% in adults and 17.9% in the elderly. The incidence of reflux esophagitis was 35.1% in adults and 42.2% in the elderly receiving the Ca antagonist. Conclusions : Our studies extended this relationship between Ca antagonist administration and reflux esophagitis, especially among the elderly. The administration of a Ca antagonist in the elderly should be borne in mind as a cause of reflux esophagitis.
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