Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 2, Issue 1
Displaying 1-11 of 11 articles from this issue
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  • On the Respiratory Depression caused by Nicotine
    Akira DOMAYE
    1956 Volume 2 Issue 1 Pages 7-11
    Published: February 10, 1956
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.2.7
    JOURNAL FREE ACCESS
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    The respiratory action of nicotine was studied and the mechanisms of the depressant actions, especially the two phases of apnoea were analyzed. A new method to record the electrical activity of phrenic nerve on the smoked paper was devised, and the following results were obtained : 1.The brief primary apnoea after the intravenous injection of nicotine is expiratory in the dog and cat, but inspiratory in the rabbit; it is due to the reflex. from the lung, whose afferent path is via the vagus nerve; and this reflex mechanism differs pharmacologically from that of veratridine or of amidines. 2.The secondary prolonged “nicotine apnoea” is expiratory ; it is not the compensatory one to the preceding hyperpnoea ; and it is probably due to the action of nicotine on the “deafferented respiratory centre.” 3.The progressively diminishing respiratory stimulation by repeated doses of nicotine is, at least partly, due to the excitability changes of the afferent or the central mechanism. 4.The respiratory failure after large doses of nicotine is caused by the paralyzing action of nicotine on the neuro-muscular junction, and not by the paralysis of the respiratory centre. The discharges from the respiratory centre, however, show several intervals of apnoeic stages and cease soon after the end of the respiratory movements. 5.These effects of nicotine on respiration, including the neuromuscular paralyzing action, are all abolished by hexamethonium. The significance of this blockade by hexamethonium is discussed.
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  • Relation of the Isolated Strains to the New Antigenic Structure
    Yoshimura FUKASAWA
    1956 Volume 2 Issue 1 Pages 12-17
    Published: February 10, 1956
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.2.12
    JOURNAL FREE ACCESS
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    The revised antigenic structure of the genus Candida which was divided separately into thermostable and thermolabile antigers was pustulated by the present authors through the antigen analysis with the seven standard strains. The antigenic structure, however, will not serve as the basis of the species classification of the genus, unless antigenic structures of the many isolated strains would coincide with that of the standard strains. In the experiment antigenic structures of twenty strains of every four species such as C. albicans, C. tropicalis, C. krusei and C. parakrusei, which had been selected at random among stock cultures, as well as a few strains of the other three species were proved to fit completely into the antigenic structure by means of slide agglutination tests with the monospecific antisera prepared on the antigenic structure. Consequently it will be concluded that the antigenic structure serves as the reliable basis of classification for the genus.
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  • A Certain Virus Obtained from the Patient Suffering from a Benign Aseptic Meningitis
    Takeshi TSUCHIYA, Kiyoaki KAMIJO, Fukuo MIYASAKI, Yoshimura FUKAZAWA, ...
    1956 Volume 2 Issue 1 Pages 18-23
    Published: February 10, 1956
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.2.18
    JOURNAL FREE ACCESS
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    A certain virus was obtained from the spinal fluid of a patient suffering from a benign aseptic meningitis and was found to be of the Dobashi strain. As to etiologic agents of the disease there may be many different organisms, but several viruses except lynphocytic choriomeningitis (LCM) and pseudo-LCM viruses were excluded on the basis of serological reactions and animal experiments. The clinical pictures of mice inoculated with the strain were completely the same to those inoculated with LCM virus described by Rivers and Scott 12) 13) , and the virus were able to pass through Berkefeld N and W candles. However, in the comparing Dobashi strain to the standard LCM virus strain by complement-fixation and cross immunity tests, results were not all favourable in identifying this strain as LCM virus. Incubation periods of the mice inoculated with the strain could be observed to be more or less shorter than Rivers' descriptions and guinea pigs inoculated with the strain did not show typical symptoms as in LCM virus. Therefore it seems to the present authors that the virus is a variety of or closely related to LCM or pseudo-LCM viruses, although the size of the virus is different from that of pseudo-LCM virus 2) .
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  • The Effect of Vitamin B6 on Motor Irritability during Insulin Shock Treatment
    Kozo SHIMOSAKA, Taturo MASUMIZU, Tatuo AKIMOTO
    1956 Volume 2 Issue 1 Pages 24-28
    Published: February 10, 1956
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.2.24
    JOURNAL FREE ACCESS
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    Vitamin B6 (Aderoxin) was administered (50-300mg) in various ways (intravenously, intramuscularly, subcutaneously and orally) to 16 cases where motor irritability was evident during awakening stage or during insulin shock treatment. In 12 cases the effective inhibitory action of this vitamin on motor irritability was shown.
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