Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 28, Issue 1
Displaying 1-18 of 18 articles from this issue
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Contents
  • A Pathomorphological Study on the Spongiosa of Vertebral Bones in Chronic Metabolic Disorders of Human Autopsy Cases and Experimental Animals.
    Part 2. A Histometrical Study on Experimental Animals Injected Carbon Tetrachloride and Cortisone Acetate, and Inoculated Yoshida Sarcoma
    YOSHIHARU ODANI
    1982 Volume 28 Issue 1 Pages 61-76
    Published: March 10, 1982
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.28.61
    JOURNAL FREE ACCESS
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    Changes of trabecular bone spicules of the 3rd lumbar vertebral spongiosa are investigated morphologically and histometrically in human autopsy cases and in experimental animals. A histological and histometrical study on the spongiosa of lumbar vertebrae of autopsy cases of liver cirrhosis, hepatomas and gastric cancers showed marked reduction in the volume percentage of trabecular bone spicules corresponding their somewhat peculiar morphological patterns (Part 1). In this report, the author designed 3 biological experiments which will show similar effects on the vertebral bone spicules. In a histometrical study, volume percentage, and absolute area and absolute length of circumference and maximum of one spiculum are measured.using a quantitative picture analyse system (BX-1; Muto Kogyo Co., Ltd.). Results : A). Repeated subcutaneous injections of carbon tetrachloride in the series of Sprague-Dawley rats for 9 weeks showed marked reduction in the volume percentage in absolute areas and in absolute lengths of circumference and in maximum of trabecular bone spicules of lumbar vertebrae spongiosa. These results are almost identical with analogical morphological patterns in the human chronic metabolic disorders. B). Repeated subcutaneous injections of cortisone acetate in the series of Sprague-Dawley rats for 7 weeks and in rabbits for 6 weeks showed almost equal patterns as that of experiment A. C). One shot intraperitoneal inoculation of the Yoshida Sarcoma cells in the series of Donryu rats showed marked coincidence with above-mentioned A and B experiments. Conclusion : In a histological and histometrical study marked reduction in volume percentage and in absolute length of circumference and maximum of trabecular bone spicules of the vertebral spongiosa and changes of bone loss of morphological patterns are found in series of three experiments such as, repeated subcutaneous injections of carbon tetrachloride and cortisone acetate in rats and/or rabbits, and one shot inoculation of Yoshida Sarcoma cells in rats. These changes were analogous to that of human autopsy cases.
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  • The Studies of Enzyme Activities in Erythrocytes from Patients with Hyperuricemia
    --HGPRTase and PRPP-ATase--
    KAZUHIKO SUZUKI
    1982 Volume 28 Issue 1 Pages 77-89
    Published: March 10, 1982
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.28.77
    JOURNAL FREE ACCESS
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    Recently it has been studied that mechanism of purine metabolism which causes gout with hyperuricemia. The author studied about PRPP-AT which is the rate limiting enzyme in de novo biosynthesis of purine nucleotide, in the erythrocytes of normal human and patients with primary gout. The results were 3.50± 1.2p mol/mg protein/20min in normal human and 2.26±1.4p mol/mg protein/20min in patients with primary gout which showed unexpectedly low grade. The reason is not certain, however, it is possible to consider that the too much produced and high concentrated IMP, because of the blocked metabolism flow into AMP and GMP which are necessary for biosynthesis of nucleic acid, prevents to show the normal PRPP-AT activity. No significant difference was observed on the value of HGPRTase, participating the salvage pathway, between the erythrocytes of normal human and patients with primary gout : namely, 48.7±14.0p mol/mg/protein/20min (Hypoxanthine) and 40.9±8.6p mol/mg protein/20min (Guanine) in the former; 50.9±20.2p mol/mg protein/20min (Hypoxanthine) and 39.2±19.8p mol/mg protein/20min (Guanine) in the latter .In 87 cases with high value of uric acid who were selected among 3,000 cases of the group examination for 3 years between 1975 and 1977, HGPRTase were measured as 57.8±19.6p mol/mg protein/20min (Hypoxanthine) and 71.6±15.2p mol/mg protein/20min (Guanine) respectively. It is remarkable point that the 11 cases showed a low activity value of HGPRTase.
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  • AClinical Study of Cryoprostatectomy.
    Part I : In Comparison with Open Prostatectomy.
    YOSHINAO HIKICHI
    1982 Volume 28 Issue 1 Pages 90-96
    Published: March 10, 1982
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.28.90
    JOURNAL FREE ACCESS
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    As patients with prostatic hypertrophy become more numerous with the increase in the population of elderly males in Japan, prostatic operation comes to occupy a more important place in the field of Urology. Although the methods of open prostatectomy and trans-urethral resection were formerly our major surgical methods, cryo-prostatectomy has been added in recent cases. During the past four years and a half from January 1976 to July 1980, we have treated nearly 200 patients ; 108 patients by open prostatectomy, 75 patients by cryoprostatectomy and 6 patients by treansurethral resection. With the exception of 6 patients treated by transurethral resection, the comparative study was made of cases treated by open prostatectomy (mainly, vesicocapsular prostatectomy) and of cryoprostatectomy. Considerations are made in terms of the age of patients, findings of clinical tests, anesthetic methods, preoperative complications and symptom of dysuria such as retention of urine and residual urine. With regards to the considerations mentioned above, the guideline was drown when to choose cryo-prostatectomy as follows : 1. when the patient wishes cryo-prostatectectomy or when the patient is advised and referred. to us by his physician. 2. when the patient is over 80 years old. 3. when the patient has a complication of other malignant tumors which cannot be radically cured. 4. when the patient has had senile dimentia or cerebral central nervous disease and yet his postoperative nursing seems problematic. 5. In addition to the cases described above, cryo-prostatectomy is often chosen for the pa tients with severe complications in the respiratomy, circulatory or kidney organs. However, in which case, the physical treatment of such complications is needed before the surgical treatment.
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