Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
Search
Advanced search
OR
Browse
Search
Volume 39, Issue 3
Displaying 1-18 of 18 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
Contents
  • A clinicopathological study of the influence of submucosal heterotopic glands on the submucosal invasion of early gastric cancer in the cardia
    SHING-HAN LIU
    1993 Volume 39 Issue 3 Pages 329-337
    Published: November 15, 1993
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.39.329
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    To elucidate the relationship between the biological features of cancer, the mode of submucosal invasion and the pathologic characteristics of submucosal heterotopic glands in the proximal third of the stomach, a clinicopathological study was performed on 73 cases of early cancer in the proximal third of the stomach (including 26 cases in the cardia and 47 cases in the so called “C portion”). From the results of this study, the characteristics of early cancer in the cardia were clarified. 1) The cardiac cases usually showed a smaller lesion measuring less than 20mm, and were differentiated adenocarcinoma histologically. 2) The ratio of cardiac cases showing submucosal invasion was 80.8%, and the crevice mode of submucosal invasion accounted for 52.4 % of these. 3) Heterotopic glands existed in 73.1% of the cardiac cases. 4) Heterotopic glands were more frequently under the cancerous lesion in the cardiac cases. 5) The distribution of heterotopic glands was mainly around the cardiac region. 6) Many cases had marked intestinal metaplasia in the surrounding mucosa, and 91.7% of the cases with marked intestinal metaplasia were accompanied by heterotopic glands. 7) All of the cardiac cases showing the crevice mode of submucosal invasion were accompanied by the heterotopic glands. More submucosal heterotopic glands existed in the cardiac region. This fact indicated that the lamina muscularis mucosa of the cardiac region may exist in some crevices. Therefore, when differentiated adenocarcinoma occurs in the cardiac mucosa, the cancerous tissue can more easily invade the submucosal layer through these crevices.
    View full abstract
    Download PDF (2158K)
  • Drug delivery system for 5-fluorouracil (5-FU)
    RUMIKO ISHII
    1993 Volume 39 Issue 3 Pages 338-347
    Published: November 15, 1993
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.39.338
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    5-fluorouracil is a useful new treatment modality for failed filtering bleb glaucoma. However, its use is attended by corneal complication. A new delivery system was studied in normal white rabbits to reduce the dose and frequency of 5-Fluorouracil administration. We developed 3 types of Drug Delivery System (DDS), (1) collagen rods containing 10% 5-FU, (2) 5-FU suppositories wrapped with ribbon gut, and (3) 20% 5-FU suppositories in collagen tubes. These were implanted underthe conjunctiva and the concentration of 5-FU conjunctiva and the concentrationof 5-FU contained in the conjunctiva (superior and inferior), sclera (superior and inferior), cornea, lens, aquaous humor, iris, vitreous body and blood were analyzed at intervals up to 4 weeks after implantation, by either bioassay or HPLC method. At the implant site of (3) type DDS (5-FU 2mg), conjunctival tissue was found to contain 2.70μg/g of 5-FU after 4 weeks. After 2 weeks, microscope revealed a reduction in the number of scleral fibroblast. After 2 weeks specular microscope showed a reduction in the number of cornealendothelial cells, but after 4 weeks, the number was recovered.
    View full abstract
    Download PDF (3287K)
  • Biotransformation of 5'-deoxy-5-fluorouridine (5'-DFUR) in gastric cancer patients
    KENICHI YAMASHITA
    1993 Volume 39 Issue 3 Pages 348-355
    Published: November 15, 1993
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.39.348
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    5'-Deoxy-5-fluorouridine (5'-DFUR) is transformed to 5-fluorouracil (5-FU) by pyrimidine nucleoside phosphorylase (PyNPase) which shows high activity in the cancer. The drug then shows a high antitumor effect because of accumulation in the tumor. The biotransformation of 5'-DFUR was studied in 47 patients who were to undergo gastrectomy for gastric cancer, and the type of gastric cancer showing higher intracancerous accumulation was determined. 5'-DFUR was administered orally in a dose of 1200mg/day for 2 days before surgery, and another dose of 400mg was given orally 4 hr before surgery. The concentration of 5-FU and PyNPase activities in the cancers, non-cancerous gastric mucosas, metastatic regional lymph nodes, and negative regional lymph nodes, were determined. The concentration of 5-FU was significantly higher in the cancers than in the non-cancerous gastric mucosa. Clinicopathologic analysis revealed that the concentration of 5-FU tended to be higher in the invasive types, 8 cm or larger lesions, undifferentiated adenocarcinomas, and those with 7 infiltrative growth (INF) than in the others. The concentraton of 5-FU in the regional lymph nodes tended to be higher in the metastatic rather than negative lymphnodes. The concentration of 5-FU in the metastatic regional lymph nodes was determined according to histological type of lesion. It was higher in undifferentiated adenocarcinomas than in differentiated ones. PyNPase activity was also significantly elevated in the cancers and metastatic regional lymph nodes, and thus high. This indicates that 5'-DFUR has the property of being accumulated in the cancer, especialy the undifferentiated adenocarcinoma with a greater extent of invasion.
    View full abstract
    Download PDF (1089K)
  • Exprimental pancreatitis: Histopathological, electronmicroscopical and immunohistochemical studies of the fibrosis of ethionine-induced pancreatitis in dogs
    AKIHIKO YAMAMURA
    1993 Volume 39 Issue 3 Pages 356-366
    Published: November 15, 1993
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.39.356
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    To investigate the mechanism of fibrosis progression in chronic pancratitis, we studied the process of pancratic fibrosis in dogs after oral administration of ethionine. DL-ethionine at a dose of 130mg/kg/day was perorally given to dogs for 7 days. Mild proliferation of fibroblasts was found in periacinar areas on day 3 after the last feeding of ethionine. On day 7, there was considerable fibrosis with proliferation of fibroblasts. Ethionine at doses of 10, 50 and 100mg/kg was given once or twice a week for 10 or 20 weeks. One week after the last feeding, mild to moderate fibrosis in intra-and interlobular and periductal areas was found. In dogs given ethionine at a dose of 75mg/kg once a week for 15 weeks, formation of fibrous connective tissues was most manifest 2 weeks after the last feeding. An increased staining of typeIII collagen and a less intense staining of type I collagen were found in all zones of fibrosis. Fibronectin was also found between collagen bundles. Such fibrosis decreased thereafter and largely disappeared after 26 weeks, (mild fibrosis was found only in periductal areas). Thus it is likely that the formation of collagen bundles and the resolution of fibrous depositions occur simultaneously between 2 and 4 weeks after the last feeding of ethionine, and that only the resolution of fibrous depositions occurs thereafter. These findings support the view that fibrosis in acute pancreatitis does not generally progress to that in chronic pancreatitis and that fibrosis in chronic pancreatitis probably occurs due to continuous pancreatic injury, which causes the release of pancreatic enzymes.
    View full abstract
    Download PDF (5611K)
  • A study on the characteristic of biological malignancy affecting the prognosis of gastric cancer with macroscopic serosal invasion
    -A quantitive evaluation of the relationship between the area of macroscopic serosal invasion and the intramural cancerous volume--
    NOBORU MIZOBUCHI
    1993 Volume 39 Issue 3 Pages 367-378
    Published: November 15, 1993
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.39.367
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    We reviewed the prognosis of 113 curatively resected cases of gastric cancer with macro-scopic serosal invasion, evaluating the relationship between the area of macroscopic serosal invasion (E-area) and the intramural cancerous volume (C-area). The characteristics of biological malignancy affecting the prognosis were noted, statistically analysing the clinicopathological factors. The E-area was redefined as the oval area calucuated from the longest diameter of the area of macroscopic serosal invasion and the right-angled diameter, while the C-area was redefined as the area of the maximum cross section through the center of the area of macroscopic serosal invasion using the automatic analysis system. The characteristics of biological malignancy of the gastric cancer with macroscopic serosal invasion were as follows; 1) In patients with an E-area over 10cm2, the prognosis was significantly poorer. 2) In patients with C-area over 5cm2, the prognosis was significantly poorer. 3) The relationship between the E-area and C-area was as follows; in patients with an E-area under 10cm2, the prognosis did not differ from those with a C-area of anysize. In patients with an E-area over 10cm2, the prognosis of patients with a C-area over 5cm2 was poor. The clinicopathological factors contributing to a poor prognosis were “se”; the depth of invasion and “poorly differentiated type”; the histopathological type. In patients with a C-area under 5 cm2, the prognosis did not differ from those with an E-area of any size. In patients with a C-area orer 5cm2, the prognosis of patients with an E-orea orer 10cm2 was poor. The clinicopathological factors contributing to poor prognosis were “se”; the depth of invasion, “poorly differentiated type”; the histopathological type, “n2 (+)”; histological lymph node metastasis and “highly lymphatic permeation”; vessel permeation.
    View full abstract
    Download PDF (1839K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top