Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 28, Issue 4
Displaying 1-14 of 14 articles from this issue
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Contents
  • The Paracervical Ganglion and Its Dependence on the Differentiation of the Reproductive Tract in the Mouse
    HIROSHIGE ISHII
    1982 Volume 28 Issue 4 Pages 499-507
    Published: 1982
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.28.499
    JOURNAL FREE ACCESS
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    The effects, of prenatal treatment with androgen or estrogen on the differentiation of reproductive tracts and their associated ganglia were studied in mice. One mg of testosterone propionate (TP) or 4μg of diethylstilbestrol (DES) were injected at the ICR pregnant mice from the ninth to 16th days of pregnancy. Offsprings were sacrificed on the day of birth, and their reproductive tracts and ganglia were examined histologically. In the female offsprings exposed to TP prenatally, reproductive tracts of wolffian duct origin as well as female reproductive tracts were found to develop. In these females, the number of neurons in the paracervical ganglia (Frankenhäuser) was significantly larger than that of control females. On the other hand, the prenatal exposure of the males to DES prevented the degeneration of the müllerian ducts. These male offsprings had both male and female reproductive tracts. The number of neurons in the ganglion was significantly larger in the DES-treated males than in control males. The number of ganglion cells of these males was almost comparable to the sum of that of the male and female controls. In prenatally DES-exposed female offsprings, the number of ganglion cells was also significantly larger than that of the female controls. These results suggest that the differentiation of the paracervical ganglion is highly dependent on the presence of a target organ, such as the müllerian or wolffian duct. In addition, a significant increase in the number of ganglion cells in DES-exposed female offsprings may suggest the possible stimulatory action of DES on the ganglion cells.
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  • The Possible Facilitatory Role of the Rostral Periventricular Preoptic Area in Secretion of Prolactin During Pseudopregnancy in the Rat
    HIROSHI WATANABE
    1982 Volume 28 Issue 4 Pages 508-514
    Published: 1982
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.28.508
    JOURNAL FREE ACCESS
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    A lesion made in the rostral periventricular region of the basal preoptic area (POA) effectively interrupted reserpin-induced pseudopregnancy in rats. However, lesions in the dorsal POA, lateral POA, nucleus and diagonal band of Broca or nucleus accumbens failed to interrupt pseudopregnancy. This suggests that the rostral periventricular POA may play a facilitatory role in regulating prolactin release during pseudopregnancy. In the rats with the lesions in the rostral periventricular POA, the interruptive effect of the lesions was reversed by daily injections of a-methyl-p-tyrosine, an inhibitor of catecholamine synthesis. Treatment with 5-hydroxy-tryptophan was also effective in maintaining pseudopregnancy in the animals bearing the rostral periventricular POA lesions. These results suggest the possible involvement of serotonergic neurons in suppressing prolactin inhibiting activity, which is mediated by dopamine neurons in the medial basal hypothalamus.
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  • Clinical and Radiologic Studies on Detection of Colo-rectal Polypoid Lesions Including Early Cancer
    YASUO SHODA
    1982 Volume 28 Issue 4 Pages 515-528
    Published: 1982
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.28.515
    JOURNAL FREE ACCESS
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    Early diagnosis is essential to cure colo-rectal cancer. Clinical manifestations and radiologic findings were studies in patients with colo-rectal lesions with special reference to the detection of polypoid lesions. Double contrast barium enema was performed in all patients.The following conclusions were obtained. 1. Clinical manifestations provide a good standard as to the site of colo-rectal lesions. 2. Twelve radiographs are suitable in routine radiologic examination. The area of the large bowel where the presence of the lesions has been presumed from clinical manifestations should be thoroughly examined. 3. The nature of large polypoid lesions can readily be assessed from frontal and profile views of double contrast studies. However, small lesions are difficult to diagnose and can only be demonstrated on radiographs that show fine network patterns. 4. The diagnosis of malignant polypoid lesions is made from size, height and profile views of the polyp and deformity of the bowel wall. 5. The smallest polyp demonstrated on a double contrast study measured 3mm in diameter. 6. Radiologically false-positive diagnosis of polypoid lesions was made in 38.3 percent of the cases. Retrospectively, this decreased to 23.4 percent. Endoscopy is necessary to correct false-positive diagnosis. Preparation for double contrast studies should be improved for accurate diagnosis. 7. The results of mass surveys using sigmoidoscopy and radiology, respectively, were compared. Radiology was superior since the entire large bowel can be visualized.
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  • Fluorescence and Absorptive Spectra of Normal & Nuclear Human Cataractous Lens Sections
    HIROSHI YOSHIDA
    1982 Volume 28 Issue 4 Pages 529-537
    Published: 1982
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.28.529
    JOURNAL FREE ACCESS
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    Changes in fluorescence intensity and spectral absorption of the normal and nuclear cataractous human lens sections have been investigated. Equatorial normal and nuclear cataractous human lens slices have absorption maxima at 280nm and 340-390nm respectively. The fluorescence spectrum of the equatorial normal human lens slice (excitation maximum : 395nm, emission maximum : 465nm) is found to decrease with the nuclear cataractous process, while the fluorescence maximum of the developed nuclear cataractous lens slices is shown to shift to 500nm with an isoemissive point of 495nm. The fluorescence intensity is found to be predominant at the perinuclear region and tends to increase with aging and the cataractous process. The posterior perinuclear fluorescence intensity is shown to be higher than the intensity of the anterior region with a depressed inner plateau. Absorption spectra obtained with the same lens sections show a similar profile to that of fluorescence intensity.
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