Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 29, Issue 1
Displaying 1-16 of 16 articles from this issue
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Contents
  • Study on the Contraction of Smooth Muscle Myofibrils from the Chicken Gizzard
    KAZUKO WATANABE
    1983 Volume 29 Issue 1 Pages 59-70
    Published: March 10, 1983
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.29.59
    JOURNAL FREE ACCESS
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    1. Phosphorylation of the myosin light chain in chicken gizzard myofibrils and its effects on myofibrillar ATPase activity were investigated under the condition of the contracture of the myofibrils. 2. The myosin light chain was phosphorylated by endogenous light chain kinase, after incubating the myofibrils for two hours at 30°C with ATP, Mg2+ and Ca2+. After standing overnight, the phosphorylated light chain was dephosphorylated by endogenous light chain phosphatase. 3. Phosphorylated and phosphorylated-dephosphorylated myofibrils showed much lower ATPase activities than did control myofibrils and were quite similar in ATPase activity. 4. The phosphorylated myofibrils apparently showed a negative Ca2+ -sensitivity in Mg2+ -ATPase. In contrast, the phosphorylated-dephosphorylated myofibril Mg2+ -ATPase was not affected by the presence or absence of Ca2+ 5. The superprecipitation particles formed by phosphorylated-dephosphorylated myosin could not be dissolved in 0.6 M NaCl, although control actomyosin gel and the superprecipitation particles formed by phosphorylated myosin could be easily dissolved under the same conditions. 6. It is concluded that the phosphorylated-dephosphorylated process of the actomyosin system in gizzard myofibrils might result in stronger actin-myosin interaction.
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  • A Clinicopathological Study of Familial Cardiomyopathy
    Osamu KOYAMA
    1983 Volume 29 Issue 1 Pages 71-86
    Published: March 10, 1983
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.29.71
    JOURNAL FREE ACCESS
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    We experienced a family predisposed to familial cardiomyopathy in which four of five siblings died from cardiological factors, and we performed an extensive survey of linear and collateral consanguineous relatives of this family. Screening tests disclosed that 43.9% of the persons concerned had cardiological abnormalities, and 19.5% were diagnosed as hypertrophic cardiomyopathy. The main pathological findings in these cases were hypertrophy, various degenerative changes and disarray of myocardial cells as well as diffuse fine fibrosis of the interstitium. These findings were not much different from those in nonfamilial indiopathic hypertrophic cardiomyopathy (ICM). These pathological changes were correlated with electrocardiographic abnormalities such as ST-T changes, an LVH pattern, low voltage, and abnormal Q waves. In addition, some cases were complicated with coronary atherosclerosis. Since the number of aged people is anticipated to increase in future, the incidence of this complication will grow accordingly, which will no doubt make it more and more difficult to establish a diagnosis of ICM. Under such circumstances, a wide range of screening covering as many blood relatives members as possible and a long-term follow-up will become essential for the discovery of potential patients as well as from a prophylactic point of view. The onset and progress of familial cardiomyopathy is considered dependent not only upon the inheritance of genetic factors but also upon the mode of living.
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  • Echocardiographic Study of Cardiomyopathy with Giant Negative T Wave
    OSAMI KUSUOKA
    1983 Volume 29 Issue 1 Pages 87-98
    Published: March 10, 1983
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.29.87
    JOURNAL FREE ACCESS
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    Giant negative T wave was observed electrocardiographically in 25 subjects without hypertension and 10 with hypertension. In addition to these, 20normal controls were selected, and echocardiography was undertaken. The diagnostic criteria of asymmetrical septal hypertrophy (ASH) are interventricular septal wall thickness of 15mm or more and interventricular septal wall thickness : left ventricular posterior wall thickness ratio of 1.3 at the cardiac base. The differences of cardiac function among the apical hypertrophy group (APH group) comprising 14 cases, the group with asymmetrical septal hypertrophy with apical hypertrophy (ASH with APH) comprising II cases and hypertensive subjects having ASH-with-APH pattern comprising 10 cases were compared with each other. Furthermore, 8cases in the APH group, 10 cases in the ASH-with-APH group, 9 cases with hypertension and 20 controls were selected for further study. Total area, muscle area and cavity area were calculated from the tomographic short axis view of LV at the end-diastolic phase with Digitizer Apple II microcomputer. These areas were then photographed with Polaroid film at the level of the chorda tendinea (base), the tip level of the papillary muscle (middle) and the basal level of the papillary muscle (apex). The ratios among these areas were ascertained for evaluating the relationships among the shortening degree of the left ventricular cavity, the difference of the left ventricular wall thickness from the cardiac base to the apex and the depth of the giant negative T wave. The GNT group showed a significant degree of left ventricular cavity shortening from the cardiac base to the apex, particularly in the ASH-with-APH group. The relationship between the apex : base muscle area ratio and the deepest GNT (mm) /the voltage of the R wave (mv) of the same lead was evaluated. The significant result that Y=2.39×+0.593, r=0.68, n=18, p<0.01 shows a positive correlation between the depth of the GNT wave corrected by its R wave voltage (mv) and the apex : base muscle area ratio. The enlargement of the apical muscle area in the APH and ASH with APH groups was due to hypertrophy of the interventricular septum, the free wall and the papillary muscle, mainly the latter.
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  • A Case of Rheumatoid Arthritis (RA) Associated with Secondary Amyloidosis
    NAOKI SUGAYA, HIROSHI HASHIMOTO, YUICHI SHIOKAWA, HIDETOSHI SATOH
    1983 Volume 29 Issue 1 Pages 99-104
    Published: March 10, 1983
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.29.99
    JOURNAL FREE ACCESS
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    The patient, a 56-year-old female with rheumatoid arthritis (RA) associated with secondary amyloidosis was reported. She was treated for RA (stage IV, class 3) for four years in our hospital. On December 8, 1981, she was admitted with epigastralgia, nausea and vomiting. On physical examination, slight clouding of consciousness and remarkably dry skin were noted. Laboratory data showed a severe decrease in total protein and an increase in serum BUN and serum creatinine. We suspected malignant RA and treated the patient with prednisolone and antibiotics. But renal failure ensued, and the consciousness level declined. She ultimately died of pneumonia. The chief autopsy findings were as follows. Pathological diagnosis : RA associated with secondary amyloidosis. A) RA : Fibrin exudation over the surface of the fibrous synovial membrane with lymphoid cell infiltration. B) Secondary amyloidosis : Major organs involved kidney, spleen, heart, thyroid gland, liver, pancreas, stomach, intestine, colon. It is very rare that major organs are examined systemically and reveal a very acute onset as in this case.
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