Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 36, Issue 4
Displaying 1-18 of 18 articles from this issue
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Contents
  • Analysis of echo-histograms of prostatic diseases
    TORU TANAKA
    1991 Volume 36 Issue 4 Pages 507-516
    Published: January 20, 1991
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.507
    JOURNAL FREE ACCESS
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    To develop a new method to quantitatively analyze of internal echo information, the average standard deviations of echo-histograms were compared with the echo patterns and clinical diagnoses. Transrectal ultrasonic images of 106 prostatic disease cases were obtained with a biplane scanner. For echo pattern analysis, the average standard deviation for heterogeneous patterns was larger than the average standard deviation of homegeneous patterns in longitudinal and transverse images. In longitudinal images, the average standard deviation for benign prostatic hyperplasia with calcification was statistically (P<0.01) larger than the average standard deviation for other diseases. In transverse images, the average standard deviations for prostatic carcinoma and benign prostatic hyperplasia with calcification were statistically (P<0.01) larger than the average standard deviations for benign prostatic hyperplasia and prostatitis. These findings correlated well with those obtained using the current diagnostic criteria of prostatic diseases. As a quantitative method, the standard deviation of echo-histograms in transverse images is concluded to be useful for echo pattern analysis and ultrasonic diagnosis of prostatic deseases.
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  • Mechanism of depression of calcium channel current by adenosine in guinea-pig ventricular cells
    MAKOTO KATO
    1991 Volume 36 Issue 4 Pages 517-526
    Published: January 20, 1991
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.517
    JOURNAL FREE ACCESS
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    The mechanism of the modulation of Ca current of cardiac muscle by adenosine was studied by recording the Ca-channel currents from cell-attached patches on isolated guinea-pig ventricular cells. The mean Ca-channel current from multi-channel Ba currents was augmented 2-3 times by the application of 100nM-isoproterenol (ISO) to the bath, and was diminished almost to the control level by the additon of 0.1mM-adenosine. Adenosine has little affect the mean current in the absence of ISO. The adenosine-induced depression of the mean current was reduced by 0.1mM-theophylline (TEO). The increase of the mean current by ISO and its reversal by adenosine occurred also in the presence of 1000nM-BAY K8644. In single-channel recordings, adenosine decreased the rate of current-containing sweeps (availability, Ps) in the presence of ISO. In five patches, Ps was increased by 100nM-ISO from 0.29±0.09 (mean±s.d.) to 0.62±0.13 and was decreased by the addition of O.1mM-adenosine to 0.37±0.15. In these experiments the mean duration of the available state (mS) was prolonged by ISO and shortened by adenosine (control 1.3±0.4s; ISO 2 : 4±0.6s; ISO and Ado1.3± 0.4 s), while the mean duration of the unavailable state (mF) was shortened by ISO and prolonged by adenosine (control 3.2±0.8s ; ISO1.4±0.5s ; ISO and adenosine 2.6±1.4s). It was not accompanied by significant changes in the open time, the close time, the open state probability or the single-channel conductance. We conclude that the decrease in the availability of the Ca-channel is responsible for the adenosineinduced inhibition of the Ca current.
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  • Evaluation of colonoscopy preparation using nonabsorbable, nonsecretory whole gut lavage solution
    YOSIKI USUI, SATOSHI YAMADA, KENJI KONDO
    1991 Volume 36 Issue 4 Pages 527-530
    Published: January 20, 1991
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.527
    JOURNAL FREE ACCESS
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    The recently-developed balanced electrolyte solution, containing polyethylene glycol and sodium sulfate, has minimal absorption and secretion of water and electrolytes in the intestinal tract, when taken orally. On fourty patients who underwent total colonoscopy, we performed whole-gut lavage using this solution for the preparation, and prospectively evaluated its effectiveness, patients' acceptance and safety. Preparation was good to excellent in quality. The lavage method was preferred by the patients to the conventional method. No adverse effect was noted. We conclude that wholegut lavage with nonabsorbable, nonsecretory balanced electrolyte solution is a valuable method in the preparation for colonoscopy.
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  • Biological activity of renal cell carcinoma measured by laminin production, and its clinical significance
    SHINJI IWATA
    1991 Volume 36 Issue 4 Pages 531-539
    Published: January 20, 1991
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.531
    JOURNAL FREE ACCESS
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    We previously suggested that laminin plays an important role in metastasis of renal cell carcinoma (RCC) since the serum laminin level was higher in RCC patients that in healthy controls and also significantly higher in RCC patients with metastatic lesions than in those with only primary lesions. In this study, we investigated of the serum laminin level in a larger number of RC C patients and conducted basic studies assuming that tumor cells produce and excrete serum laminin, thereby affecting the clinical course. The serum laminin level was higher in RCC patients than in the healthy controls and tended to decrease after nephrectomy. The serum laminin level was significantly higher in patients with metastatic lesions than in those with only primary lesion. Conversely, no clear correlations existed between the serum laminin level and the tumor size, degree of histological malignancy or degree of tumor invasion. The serum laminin concentration tended to be higher in renal venous blood than in renal arterial blood. The supernatant of tumor tissue homogenates contained much laminin, Which correlated positively with the serum laminin concentration. Moreover, the laminin concent ration in the renal carcinoma cell culture supernatant increased with time. Therefore, RCC was surmised to be a laminin-secreting tumor. The positive correlation between the tumor tissue and serum laminin concentration suggests that a patient's serum laminin level reflects laminin production capacity. The higher serum laminin level in RCC patients with metastatic lasions, suggests that metastasis of RCC is closely related to each patient's laminin production, which can be estimated from the laminin level in the peripheral blood.
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  • An investigation of incidental hypouricemia
    KAZUHIKO YAMAMOTO, HIROKO MOROOKA
    1991 Volume 36 Issue 4 Pages 540-550
    Published: January 20, 1991
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.540
    JOURNAL FREE ACCESS
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    The clinical significances of incidental hypouricemia, excluding xanthinuria and a drug-induced-hypouricemia were examined. The criteria of hypouricemia applied was less than 1.7mg/dl serum uric acid level, which was a value of - 2 SD to an average value of 3070 randomised specimens in the clinical laboratory of Juntendo University Hospital. In all patients with incidental hypouricemia malnutrition was speculated because time series analysis of individual patients showed a significant correlation between uric acid level in serum and total cholesterol levels in serum. In the patients fasted the uric acid level decreased 50% for 5 days after the beginning of the fast, and recovered to the initial level about 8 days after resumption of nutritional intake. These findings strongly suggest that low dietary intake of uric acid cause hypouricemia. This speculation was supported also by the cluster analysis of other laboratory data.
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