Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 25, Issue 4
Displaying 1-16 of 16 articles from this issue
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Contents
  • Histopathological Studies on Intestinal Behçet's Disease
    ISAMU WATANABE
    1979 Volume 25 Issue 4 Pages 450-473
    Published: December 10, 1979
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.25.450
    JOURNAL FREE ACCESS
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    Nine cases of intestinal Behçet's disease were studied histopathologically to clarify characteristic pathological and vascular changes and compared with Crohn's disease, tuberculosis of the intestine and ulcerative colitis using the surgically resected intestinal materials. The following results were obtained. 1. The intestinal ulcers of Behçet's disease were pathologically classified into the three types : necrotic, granulomatous and combined. 2. From the pathological point of view, it was believed that the necrotic-type ulcers were acute or subacute and the granulomatous type were chronic. However, there was little clinical compatibility. 3. Main intestinal ulcers (2cm<) were multiple, round, deep and located on the opposite side of mesenterium in the ileocaecum. 4. Small intestinal ulcers (<2cm) were round or star-like with no fusion, multiple and located on the small intestine. 5. Histopathologically, the main ulcers showed non-specific inflammatory reaction with fissuring. There were small ulcers with fissuring in the cases with necrotic and granulomatous types. The cases with combined type showed healed scarred ulcers. 6. Histopathologically, the ulcers showed weak collagen fiber reaction. It was believed that perforations and small deep ulcer formations in intestinal Behçet's disease were caused by weak collagen fiber reaction. 7. Dilatation of the lymph vessels, venous congestion, edema and edema scleroticum in the submucosa of the area surrounding the ulcers as well as the non-ulcerative area were noted. Serositis was seen in all cases. 8. Vascular-change-dependent intestinal ulcers were seen in the area surrounding the deep ulcers in intestinal Behçet's disease. The size of the affected blood vessels ranged from 100 to 300μ in diameter. Venous changes were intimal proliferation and thrombus formation. Arterial change was intimal fibrous thickening. Venous changes were severer than arterial. Similar vascular changes were observed in the area surrounding the ulcers in Crohn's disease, ulcerative colitis and tuberculosis of the intestine. 9. There was no vascular change in the small, shallow ulcers (Ul-II) in intestinal Behçet's disease except for serosal venous changes in the combined type. The necrotic type with acute ulcers showed slight venous changes compared with those of the granulomatous and combined types with chronic ulcers, and no arterial changes. Vascular changes had a close relationship to the depth and duration of the ulceration but none to the size. In conclusion, vascular changes in the area surrounding the ulcers in intestinal Behçet's disease were believed to be secondary.
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  • Experimental and Clinical Study on the Thyroidography
    SABURO SHIMAO
    1979 Volume 25 Issue 4 Pages 474-481
    Published: December 10, 1979
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.25.474
    JOURNAL FREE ACCESS
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    Experimental and clinical study of thyroidography recently, thyroidography (thyroidolymphography) has been applied to the diagnosis of thyroid tumors by an injection of a contrast medium directly into the thyroid gland. An image of the tumor was produced more clearly than in scanning procedures or USEG. 1. An experimental study of 12 dogs was undergone to determine the suitable dose of contrast medium to be injected into the thyroid gland. Conclusively, the suitable injected dose of lipiodol to one thyroid lobe was 0.05ml. 2. One hundred and seven autopsy cases were studied on the size of the thyroid glands. The average weight of thyroid gland was 13.40±5.45g and the average length was 4.68±0.78cm in right lobe, 4.45±0.71cm in left. 3. One the standpoint of the size of human thyroid gland, the suitable dose of contrast medium to one lobe was 0.3-0.5ml, conclusively. 4. One hundred and forty one cases with thyroid disease were treated in our department from 1972 to 1978. Radiological and pathological examinations of 75 cases were made. There were three radiological types (cystic, lobular and solid) of thyroid disease. 5. Radiological and pathological examination of regional lymphnodes showed a radioglaphical difference between malignant and benign tumor of thyroid gland.
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  • Prostaglandin F2α Metabolite Levels in Arterial Blood, Right Lymph Duct Lymph and Respiratory tract Fluid in Alloxan-induced Pulmonary Edema.
    YOICHI CHIJIMATSU
    1979 Volume 25 Issue 4 Pages 482-491
    Published: December 10, 1979
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.25.482
    JOURNAL FREE ACCESS
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    Alloxan-induced pulmonary edema was produced in dogs in order to investigate the pathogenesis of pulmonary edema and prostaglandin release in lung. Pulmonary edema was induced in dogs by intravenous injection of alloxan (150mg/kg), and samples from arterial blood, right lymph duct (RLD) lymph and respiratory tract fluid were assayed for the measurement of the main metabolite, 15-keto 13, 14 dihydro PGF2α. Arterial plasma concentrations of the PGF2α-M were 0.75±0.17 (SEM) in controls, and increased to 2.96±0.90ng/ml (p<0.005), when pulmonary edema was induced. PGF2α-M levels in RLD lymph increased from 1.19±0.43 to 3.38±0.95ng/ml after onset of edema (p<0.0125). Respiratory tract fluid during the presence of edema contained about the same level of PGF2α-M with that in RLD lymph. Appearing edema, RLD lymph flow increased from 3.3 to 17.8ml/h, and lymph/plasma protein ratio increased from 0.56 to 0.86. Electron microscopy examination showed swelling of the alveolar interstitium, desquamation of the type I epithelium and an increase in number of pinocytotic vesicles and vacuoles in the capillary endothelium. These high concentrations of PGF2α-M in arterial blood, RLD lymph, and respiratory tract fluid suggested an enhanced release of PGF2α or its precursor in the lung along with the induction of pulmonary edema. The findings by electron microscopy indicated the damage of the type I epithelium as well as capillary endothelium in alloxaninduced pulmonary edema.
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  • Clinicopathological Classification of Primary Glomerulonephritis
    YASUHIKO TOMINO
    1979 Volume 25 Issue 4 Pages 492-501
    Published: December 10, 1979
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.25.492
    JOURNAL FREE ACCESS
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    A clinicopathological classification of primary glomerulonephritis is proposed. This classification based on the histopathological characteristics as well as the clinical features of this disorder. Histopathological findings are most helpful in diagnosis when immunofluorescent and electron microscopy are performed in association with routine light microscopic examinations of renal biopsy specimens. These histopathological findings have to be evaluated by the clinical courses of individual patients, and vice versa. It is suggested that the classification of primary glomerulonephritis based on both histopathological and clinical observations is mandatory to diagnose the disease, to select therapeutic procedures, and to estimate the prognosis of each patient.
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