Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 42, Issue 1
Displaying 1-22 of 22 articles from this issue
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Contents
  • Trends in mortality from ischemic heart disease, and the relationship
    between occupation and sudden death in Japan
    TERUHIKO HISAOKA
    1996 Volume 42 Issue 1 Pages 55-64
    Published: May 30, 1996
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.42.55
    JOURNAL FREE ACCESS
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    To clarify the accurate mortality of ischemic heart disease and the relationship between occupation and sudden death in Japan, we analyzed the autopsy records riegistered in the “Annual of Pathologically Autopsied Cases in Japan (1959-1989)”, in comparison with randomly selected non-sudden death cases as controls. The percentage of sudden death in the autopsied cases rewained relatively constant from 1959 (0.62%) to 1975 (0.54%). However, the rate rose in 1984 (1.06%) and continued to rise until 1989 (1.46%). The corrected age-adjusted mortality from ischemic heart disease, being approximately twice of the mortality reported on the Official Statistics, reached a maximum in 1979, decreased slightly in 1984 and rose again in 1989. The mean age of sudden death cases in each occupational group was low compared with that in the controls. A significant difference was recognized among those in transportation/communication and mining. The mortality among sudden death cases in transportation/communications or security rated aignificantly higher than that in control cases. In conclusion, the actual mortality from ischemic heart disease is possibly twice that indicated in the Official Statistics of Japan. Furthermore, occupational stress may play an important role in triggering sudden death among Japanese employes.
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  • A comparative study of postoperative impairment following the use of various types of cervical manual anastomosis (retrosternal) and intrathoracic uppermediastinal mechanical anastomosis for esophageal carcinoma
    YOZO WATANABE, HIDENORI TSUMURA, FUMIO MATSUMOTO, SHUICHI SAKAMOTO, TA ...
    1996 Volume 42 Issue 1 Pages 65-71
    Published: May 30, 1996
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.42.65
    JOURNAL FREE ACCESS
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    The present study examined postoperative impairment following intrathoracic uppermediastinal mechanical anastomosis which was introduced in December 1991 to sequelae such as stenosis or dysphagia following surgery on esophageal carcinoma. Findings were compared with various types of manually sutured cervical anastomoses previously employed, and surgical techniques were assessed in view of these findings. The sujects of the study comprised 14 cases of Gambee 1-layer anastomosis (G1-layer method), 17 cases of stratified 2-layer anastomosis using interrupted sutures (2-layer interrupted method), and 26 cases of stratified 2-layer anastomosis using continuous sutures (2-layer continuous method), 26 cases of mechanically sutured intrathoracic uppermediastinal anastomosis, for a total of 83 subjects. The followings were investigated : (1) Day oral alimentation commenced. (2) Onset of suture insufficiency. (3) Incidence of suture insufficiency. (4) Incidence of postoperative stenosis. (5) Incidence of postoperative dysphagia. The interval before the resumption of ordinary meals was 2-3 weeks in subjects with various types of cervical anastomosis, compared with the significantly shorter interval of approximately 10 days in subjects with mechanical anastomosis. The onset of suture insufficiency was delayed in the G 1 -layer method group, 2-layer interrupted suture group, and 2-layer continuous suture group, in that order. The incidence of suture insufficiency, incidence of postoperative stenosis, and incidence of postoperative dysphagia decreased in the following order : G1-layer method, 2 -layer interrupted suture method, 2-layer continuous method, and mechanical suture method. Thus, these data indicated that from the perspective of postoperative impairment, mechanical anastomosis constitutes a superior reconstruction technique following surgery for esophageal carcinoma compared to various types of manually stutured cervical anastomoses.
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  • Expression of extracellular matrix (ECM) components and various cytokines in glomeruli in patients with IgA nephropathy
    TAKAO KURAMOTO
    1996 Volume 42 Issue 1 Pages 72-81
    Published: May 30, 1996
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.42.72
    JOURNAL FREE ACCESS
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    Expression of glomerular matrix (ECM) components was examined by immunofluorescence in patients with IgA nephropathy. Expression of 7S type IV collagen, laminin, fibronectin and type I collagen in the advanced stage of IgA nephropathy was significantly greater than that in the mild stage of IgA nephropathy. In the advanced stage of IgA nephropathy, staining of IgA, C3 and ECM components was marked in the glomerular mesangial areas and capillary walls. Cytokines such as IL-1, IL-2, PDGF and TNF-α were marked in the glomeruli of the advanced stage of IgA nephropathy. It appears that overproduction of the ECM components might induce glomerular injuries in IgA nephropathy. The accumulation of 7S type N collagen, laminin and fibronectin might be enhanced by the secretion of some cytokines in IgA nephropathy.
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  • Effect of high glucose on the expression of cathepsin B, L and cystatin β in cultured rat mesangial cells
    YUICHIRO MAKITA
    1996 Volume 42 Issue 1 Pages 82-91
    Published: May 30, 1996
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.42.82
    JOURNAL FREE ACCESS
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    To elucidate whether thickening of the glomerular basement membrane and mesangial expansion due to storage of extracellular matrix proteins in diabetic nephropathy were due to either overproduction of extracellular matrix proteins or suppression of their degradation or both, we analyzed changes of cysteine proteinases, cathepsins B and L, and their specific endogenous inhibitor, i.e., cystatin β, in cultured glomerular mesangial cells treated with medium containing high concentration of D-glucose (27.8mM) at both enzyme activities, protein and mRNA levels. RNA blot hybridization analyses of the cultured mesangial cells showed that mRNAs for both cathepsins were induced after 6 hours of treatment but were suppressed after more than 12 hours of treatment, while mRNA for cystatin β increased after 24 hours of treatment with high glucose. Enzymatic activities of cathepsin L increased 1.4-fold after 6 hours of treatment with high glucose, then declined gradually to 72% of the control value after treatment for 36 hours. Change in the enzyme activity of cathepsin B in the cultured mesangial cells treated with high glucose showed a similar time course but the magnitude was less than that of cathepsin L. Immunoblot analysis with anti-cathepsin L antibody showed that change in the enzyme activity of cathepsin L was partially due to the change in the amount of cathepsin L, while that with anti-cathepsin B antibody showed no change in the amount of cathepsin B in cultured mesangial cells treated with high glucose. These results suggest that intracellular cathepsin activities were controlled not only by the amounts of cathepsin but also by the amounts of inhibitor, cystatin β. Immunoblot analysis of mesangial cells treated with high glucose by anti-cystatin β antibody showed that intracellular levels of cystatin β slightly increased after 24 hours of treatment with high glucose. These results, therefore, demonstrate that thickening of the glomerular basement membrane and mesangial expansion were partially due to both suppression of cathepsins and increase of cystatin β.
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  • Role of extracellular matrix on colonic cancer cell migration and proliferation
    KEIICHI OHTAKA
    1996 Volume 42 Issue 1 Pages 92-98
    Published: May 30, 1996
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.42.92
    JOURNAL FREE ACCESS
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    We developed a simplified method for quantitatively analyzing the migration capacity of colonic cancer cells line (SW837) in vitro to clarify the mechanism of cancer metastasis. We used this model to investigate the effects of extracellular matrix (ECM) components such as collagen type I and type IV, laminin, and fibronectin on the migration of these cancer cells. As a result, the migration of these cancer cells was fastest on laminin and slowest on collagen type I. In this study the type of ECM used modulated both cell migration and proliferation. These findings suggest that the ECM plays an important role in the mechanism of cancer metastasis.
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