Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 33, Issue 1
Displaying 1-18 of 18 articles from this issue
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Contents
  • Regeneration of Pancreatic Acinar and Endocrine Cells After DL
    ethionine Administration in the Rat
    MASANOBU EGUCHI
    1987 Volume 33 Issue 1 Pages 47-58
    Published: March 10, 1987
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.33.47
    JOURNAL FREE ACCESS
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    To determine the pathological process of pancreatic cell regeneration, histological, electron microscopic, histochemical and immunohistochemical studies were carried out in the rat after DL-ethionine administration. Pancreatic acinar cell regeneration followed by necrosis and destruction by DL-ethionine administration occurred as early as three days after the termination of DL-ethionine administration. Histochemically recognized γ-GTP activity in such pancreata was restored rapidly to the control value in parallel with the histopathological restoration. Electron microscopic observations supported this view, and the author suggests that functional restoration of pancreatic exocrine cells begins at an earlier phase and finishes within a shorter period than has been assumed. Pancreatic endocrine cells also regenerated at an early phase, and these cells were found in ductal and/or ductular epithelia as well as in lobuli as isolated endocrine cells. Most of these endocrine cells coincided with insulin-producing B cells.
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  • Histopathological Studies on Vascular Lesions of the Liver, Gallbladder and Pancreas in Collagen Diseases
    吉峰 二夫
    1987 Volume 33 Issue 1 Pages 59-73
    Published: March 10, 1987
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.33.59
    JOURNAL FREE ACCESS
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    Studies on vascular lesions of the liver, gallbladder and pancreas in collagen diseases have rarely been documented. The author systematically and histopathologically examined vascular lesions of the liver, gallbladder and pancreas in 62 autopsy cases of collagen diseases, including 25 of systemic lupus erythematosus (SLE), 13 of rheumatoid arthritis (RA), seven of polyarteritis (PN), six of progressive systemic sclerosis (PSS), four of dermatomyositis (DM), two each of allergic granulomatous angitis (AGA), and Wegener's granulomatosis (WG), and one each of mixed connective tissue disease (MCTD), Schönlein Henoch purpura (S-H P), and adjuvant disease (Adj). The results were as follows : 1) Thirty-five out of 62 revealed panarteritis with fibrinoid degeneration (14 cases) or arterial scar lesions (21 cases). 2) The arterial lesions were predominantly distributed in the hepatic hilus, the gallbladder and the pancreatic head areas. 3) The lumina of the branches of the hepatic and splenic arteries in the SLE, RA, PN and PSS groups were much narrower than those of the main hepatic and splenic arteries in each group, except for the branch of the splenic artery in RA. 4) The incidence of luminal stenosis (over 40%) of branches of the hepatic and splenic arteries was higher in the groups with SLE, RA, PN and PSS than in the control group. More severe arterial luminal stenosis (over 75 %) was frequently found to be associated with arteritis. 5) The pathological findings of the liver consisted of necrosis of the hepatic cells, congestion, fatty metamorphosis of the hepatic cells, bile stasis, inflammatory cell infiltration and fibrosis in the periportal area. 6) A higher incidence of fatty metamorphosis of the hepatic cells was observed in the group receiving more than 2500mg of steroids (prednisolone) than in that administered less than 2500mg. 7) The pathological findings of the pancreas consisted of arteriolar hyalinosis, partial hyalinosis of the islets, focal parenchymal necrosis and fibrosis. 8) In one case of MRA, focal pancreatic necrosis was confirmed to have been caused by arteritis with mural occlusive thrombosis. In one case of AGA. mucosal erosion of the gallbladder was highly presumed histopathologically to have been caused by arteritis with severe luminal narrowing.
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  • Basic Study on Drug-induced Myelotoxicity
    -An Application of Bone Marrow Testing to Toxicity Study-
    KIYOSHI MATSUMOTO, TOSHIKAZU SHIRAI
    1987 Volume 33 Issue 1 Pages 74-86
    Published: March 10, 1987
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.33.74
    JOURNAL FREE ACCESS
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    To develop a technique for detecting drug-induced myelotoxicity in rats, we investigated the relationships between the bone marrow and anemia due to repeated blood collection or four days of drug administration after measuring the nucleated cell and marrow-cell differential counts of the femoral bone marrow of male Wistar rats. Marrow nucleated cell counts declined with week age. The G/E ratio increased by the age of nine weeks and became a constant value (1.0) indicating this was rat's maturation age using marrow cells as an indicator. When the RBC dropped to less than 80% of control, the MCV began to increase. Repeated daily blood collection of 0.3% of the total blood volume did not change any blood parameters without the WBC in four days. From the results of marrow cell measurements in rats treated with repeated blood collection and drug administration, increase of erythroblasts by the administration of phenylhydrazine, 4-dimethylaminoazobenzene and zinc ethylphenyldithiocarbamate, decrease of erythroblasts by para-sec-butylphenol and decrease of all marrow cells by mitomycin C and 5-fluorouracil were observed. These findings not only made it possible to detect whether unknown drugs have direct effects on the peripheral blood cells and/or bone marrow cells or not, but also underscore the usefulness of bone marrow examination in toxicity study.
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  • Hypothalamic Laterality in Regulating Gonadotropic Function
    Unilateral Hypothalamic Lesion and Ovarian Compensatory Hypertrophy
    MASARU FUKUDA
    1987 Volume 33 Issue 1 Pages 87-94
    Published: March 10, 1987
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.33.87
    JOURNAL FREE ACCESS
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    In order to examine the possible left-right difference in hypothalamic gonadotropic function, the effects of unilateral hypothalamic lesions on the development of ovarian compensatory hypertrophy (OCH) in hemiovariectomized rats were investigated. A unilateral lesion was made stereotaxically on either the right or left side of the anterior hypothalamus (RAHL or LAHL); at the same time, the ovary ipsilateral or contralateral to the hypothalamic lesion was removed and weighted. Two weeks after the surgery, the fresh weights of the remaining ovary were recorded. Regardless of the side of the hemiovariectomy, A unilateral lesion in the right medial anterior hypothalamus markedly suppressed OCH, whereas one made in the left side failed to do so. This suppressive effect of RAHL on OCH was still observed at three and six weeks after surgery. These results suggest the presence of hypothalamic laterality in regulating gonadotropin secretion. In addition, blood levels of FSH and LH were measured during the development of OCH in rats with unilateral hypothalamic lesions. Although no significant change in LH was detected, serum FSH increased markedly six hours after hemiovariectomy in the controls and animals with LAHL. However, this increase of FSH could not be observed in the animals with RAHL in which OCH was effectively suppressed. Although it is not yet certain whether the increase of FSH seen at six hours posthemiovariectomy is essential for the development of OCH, the right anterior hypothalamus plays a critical role in regulating the release of FSH at the initial stages of the development of OCH.
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  • Pathological Studies on the Histogenesis of Carcinoma of the Gastric Remnant
    RYO WADA
    1987 Volume 33 Issue 1 Pages 95-109
    Published: March 10, 1987
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.33.95
    JOURNAL FREE ACCESS
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    In order to study the background and histogenesis of carcinoma of the gastric remnant, 50 patients with gastric remnants including 25 with carcinoma of the gastric remnant were examined pathologically. Carcinoma of the gastric remnant, except for stomal carcinoma, was present in the gastric remnant with diffuse intestinal metaplasia and frequently showed well-differenciated type adenocarcinoma. Stomal carcinoma coexisted with stomal gastritis. In the area of stomal gastritis, hyperplastic foveolar epithelium, atrophy of the gastric glands, and cystic dilatation of mucosal and submucosal glands were noted. Mucosal cystic and submucosal glands were seen more frequently in the stomal area of B-II control cases than in those with B-I. The epithelial cells of mucosal cystic glands and submucosal glands were partially stained by concanavalin-A (III), secretory components, and lysozyme. The appearance of strongly lysozyme positive cells in the mucosal cystic glandular epithelium was more frequently found in the control cases with B-II than in those with B-I and more frequently in stomal carcinoma than in the control cases with B-II. It is emphasized that there is a relation between the presence of stomal carcinoma and the appearance of strongly lysozyme positive cells in the epithlium.
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