Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 35, Issue 3
Displaying 1-21 of 21 articles from this issue
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Contents
  • Ultrasonographic diagnosis of metastatic liver carcinoma
    MORIO GONDOH
    1989 Volume 35 Issue 3 Pages 369-378
    Published: October 20, 1989
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.35.369
    JOURNAL FREE ACCESS
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    Ultrasonographic and computed tomographic findings were compared in 108 lesions of liver metastasis less than 4 cm in diameter. The sensitivity was 96% for ultrasonography and 79 % for computed tomography. However, for lesions less than 1 cm in diameter, the sensitivity for ultrasonography was 83% and that for computed tomography 46%. Detection by ultrasonography was low in segments 7 and 8 of the liver. We reviewed ultrasonographic findings of 245 cases of liver metastasis. Alimentary tract cancers, such as colorectal, gastric and pancreatic cancers, often showed an elevation of the echo level, marginal hypoechoic zone and central liquefaction with growth of these cancers. All lesions larger than 4 cm appeared as an echogenic area. In colorectal and gastric cancers, no ultrasonographic differences were noted among the histological types, except for leiomyosarcoma of the stomach. A comparative ultrasonographic and pathohistological study was performed in 16 cases of liver metastasis after chemotherapy. Echo levels of metastatic lesions varied with the grade of necrosis of cancer tissue, with lesions of low grade necrosis appearing as a hypoechoic area and those of high necrosis as a hyperechoic area. The elevation of echo level of the surrounding liver tissue was caused by fatty changes and necrosis. The findings of homogenous elevation of internal echoes and marginal hypoechoic zones may be useful for evaluating the effect of chemotherapy for tumors.
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  • Transplantation of ear cartilage autograft and the preserved homograft sclera in rabbits
    RIE YOSHIKATA
    1989 Volume 35 Issue 3 Pages 379-391
    Published: October 20, 1989
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.35.379
    JOURNAL FREE ACCESS
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    The transplantation of the ear cartilage and the preserved sclera have been utilized in the reconstruction of the eyelid or orbit in oculo-plastic surgery. In this study, the histological changes and fate of ear cartilage and preserved homograft sclera transplanted in rabbits were investigated. When the materials were transplanted on the subconjunctival layer with one side of the graft exposed the marginal layer of the ear cartilage became fibrotic but survived, and the surrounding tissue formed a fibrous capsule. On the other hand, the collagen fibers of the transplanted sclera became thin and the transplanted sclera was replaced by the connective tissue. Thus, cartilage was considered to be a more reliable tissue for reconstruction of the eyelids. Regeneration of the conjunctiva occurred earlier on the exposed surface of the cartilage than on that of the sclera. All cartilage transplanted under the conjunctiva, under the back skin and in the skeletal muscle survived with only slight inflammatory reaction, except in the skeletal muscle grow where slight absorption and ossification were observed. The sclera was completely replaced by the fibrous tissue except in the group transplanted under the conjunctiva and the back skin.
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  • Diagnostic values in combination with biliary system enzymes and CA 19-9 in patients with biliary cell carcinoma
    YOKO OIKAWA, OSAMU YAMANAKA, TOSHIHIKO IIJIMA
    1989 Volume 35 Issue 3 Pages 392-396
    Published: October 20, 1989
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.35.392
    JOURNAL FREE ACCESS
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    We evaluated the usefulness of measuring serum biliary system enzymes and carbohydrate antigen 19-9 (CA19-9) in the diagnosis of biliary cell carcinoma. Among 245 patients with elevated levels of serum biliary system enzymes, 62 patients showed abnormal CA 19-9 levels. Thirty-four of these 62 patients were found to have malignant diseases, and 14 had biliary system carcinoma, including 6 with biliary cell carcinoma. Five patients with biliary cell carcinoma exhibited CA 19-9 levels over, 1,001u/ ml. The rate of detection of biliary cell carcinoma was increased significantly by the concomitant measurement of CA 19-9 and biliary system enzymes.
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  • Possible role of aromatization in the development of sexual dimorphism
    in the anteroventral periventricular nucleus of the preoptic area in the rat
    MASAHIRO MACHIDA
    1989 Volume 35 Issue 3 Pages 397-403
    Published: October 20, 1989
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.35.397
    JOURNAL FREE ACCESS
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    This study examined whether aromatization from androgen to estrogen is a prerequisite for sexual dimorphism of the anteroventral periventricular nucleus (AVPvN) in rats. The female rats were injected subcutaneously with 500μg of testosterone (T), 500μg of 5α-dihydrotestosterone (DHT) or 50μg of estradiol (E2) for 5 days after birth. Other females were injected with 100μg of tamoxifen concurrently with 500μg of T for the first 5 days of life. They were killed at 90 days of age. Untreated males and females were used as age-matched controls. In the controls, the volume of the AVPvN was significantly (2.6-fold) greater in the females than in the males. However, the volume of the AVPvN in T-treated and E2-treated female rats was a significantly reduced to a level comparable to that of male controls. The AVPvN of 5α-DHT-treated female rats was slighly decreased in volume, compared to the female controls, but it was significantly greater than that of T-treated and E2-treated female rats. In contrast, simultaneors injection of tamoxifen and T had no effect on volume of the AVPvN. These results suggest the importance of aromatization from androgen to estrogen in inducing sexually dimorphic changes in the developing AVPvN of the rat.
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  • Collagen metabolism in the Marfan syndrome
    AKIRA MURAKAMI
    1989 Volume 35 Issue 3 Pages 404-412
    Published: October 20, 1989
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.35.404
    JOURNAL FREE ACCESS
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    The collagenous proteins produced by cultured skin fibroblasts obtained from 18 cases of Marfan syndrome were analyzed. The skin fibroblasts were labeled for 24 hr. with [(3H] -proline, and the proteins in the medium were examined by SDS-polyacrylamide gel electrophoresis. There was no evidence of structural defects in type I and type III collagen. However, an additional 185 KDa collagenous protein band was observed after reduction in the culture medium in 4 of 18 Marfan syndrome patients. This band was not detected in the medium from 29 control fibroblasts. Based on its reactivity with the antibodies to human type IV collagen and the results of CNBr peptide mapping, the 185 KDa collageneous protein was identified as α1 (IV) chain. The production of type IV collagen by the fibroblasts from the Marfan syndrome patients might reflect veiled abnormalities in collagen metablism in the disease.
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  • Annual statistics on mortality in the First Department of Surgery, in Juntendo University Hospital, 1988
    TAKASHI SAKAKIBARA, TAKANORI HABA, NOBURU SAKAKIBARA
    1989 Volume 35 Issue 3 Pages 413-417
    Published: October 20, 1989
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.35.413
    JOURNAL FREE ACCESS
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    A total of 762 patients were treated at the first Department of Surgery, Juntendo University Hospital from December 1, 1987 to November 30, 1988. Among them, 66 patients (8.7%) died. The cause of death in 59 patients was a malignant disease. Statistical comparison of the mortality rate over time revealed that the proportion of patients whose died of a benigh disease has significantly decreased. The main reason for this was considered to be the steady decrease in deaths due to postoperative complications. Based on these findings, it is necessary to emphasize the importance of early diagnosis and combined therapy for treating malignant diseases.
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