Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 21, Issue 2
Displaying 1-11 of 11 articles from this issue
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Contents
  • Application of Ferrite as a Contrast Media to Gastrointestinal X-ray Diagnosis (1)
    SHIGEYOSHI TAMURA, MINORU KURIHARA, MASATSUGU HARAIKAWA, MASAKUNI MURA ...
    1975 Volume 21 Issue 2 Pages 151-162
    Published: June 10, 1975
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.21.151
    JOURNAL FREE ACCESS
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    Application of Ferrite as a Contrast Media to Gastrointestinal X-ray Diagnosis (I). Ferrite is a strongly magnetic substance and can be used for a contrast media in the gastrointestinal x-ray examination, as have been pointed by a few authors. We studied radiologic properties of the solution of this subatance. When comparing with the barium sulfate solution, the most common contrast media for the gastrointestinal x-ray examination, the ferrite solution is less flocculant even by increased acidity, and it shows better coating of a surface. In those experiments which test x-ray absorption, homogenousity and sedimentation of the solution, it was proved that the ferrite is inferior to the barium sulfate. So, some problems are unresolved on the clinical use of this contrast media. In demonstrating a numder of models simulating to both elevated and depressed lesions of the gastric wall the ferrite solution made to be detectable smaller changes than the barium sulfate. The second series of our further experiments indicate that, if a lesion is located on the anterior wall of the upper portion of the stomach, an improved radiological examination will be expected with the ferrite solution.
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  • Application of Ferrite as a Contrast Media to Gastrointestinal X-ray Diagnosis (II)
    MASATSUGU HARAIKAWA, MINORU KURIHARA, HIKOO SHIRAKABE, SHIGEYOSHI TAMU ...
    1975 Volume 21 Issue 2 Pages 163-172
    Published: June 10, 1975
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.21.163
    JOURNAL FREE ACCESS
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    The radiologic properties of the ferrite solution ware the subject of our previous report. This solution, when compared with barium sulfate solution, showed 1) lower x-ray absorption, 2) linear increasement in density by the high pressure exposure, 3) less flocculation in presence of strong acid, and 4) superior demonstrability both of elevated and depressed superficial changes. In a series of animal experiments this medium had been used to show muscal chages, both of an ulcer and a cancer, which had been made in the stomach of various experimental animals. By these projections the ferrite solution found was demonstrated to be superior to the barium sulface solution, when used for coating the mucosal surface of the anterior wall. This contrast medium was thus considered to fit into the demonstration of lesions of the anterior wall of the stomach. It was difficult to demonstrate the experimenal ulcer by magnetic control, because we had no apparatus to change the direction of magnetics. On a level of these animal experiments toxicity of this medium was negligeible.
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  • RNA Synthesis and Effects of Steroid Hormone on Lymphocytes of Human Peripheral Blood Stimulated with Phytohemagglutinin (PHA)
    YOSHIHISA WAKABAYASHI
    1975 Volume 21 Issue 2 Pages 173-181
    Published: June 10, 1975
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.21.173
    JOURNAL FREE ACCESS
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    In this study, RNA synthesis in lymphocyte stimulated with phytohemagglutinin (PHA) and the effects of steroid hormones on it were investigated by the measurement of H3-uridine incorporation into RNA. RNA synthesis in lymphocytes was markedly stimulated within 2 hours after incubation with PHA, and went up to maximum at 24 hours after incubation. But without PHA, however, it was slightly stimulated. The ratio of RNA synthesis in lymphocytes at 24 hours after incubation in the two groups stimulated with PHA and added no PHA was 3.8 : 1. 0. RNA synthesis of lymphocytes stimulated with PHA was remarkably suppressed by various steroid hormones (hydrocortisone, predonisolon or paramethasone), and the suppressive effects was clearly dependent on the dose. Without PHA, however, the suppressive effect of steroid hormones on RNA synthesis in lymphocytes was slightly demonstrated. The author expects that these data would be clinically useful in immunosuppressive therapy.
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  • Results of Steroid Therapy on the Adult Primary Nephrotic Syndrome
    HIDEMITSU, YAMASHITA , HIROMICHI YAMAZAKI, KEIICHIRO KABUKI, NOBORU SO ...
    1975 Volume 21 Issue 2 Pages 182-193
    Published: June 10, 1975
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.21.182
    JOURNAL FREE ACCESS
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    Eighty-six patients with primary nephrotic syndrome in our clinic were classified according to Burch's classification, and the relationship swas studied between histological changes and therapeutic effects with steroid. 1) In forty-one cases (47.7%), the biopsies of the kidney revealed the minimal histopathological change. The averaged age of the onset was 24.1 years of age in this group. 2) In the patients responded to steroid therapy, the proteinuria, hypoproteinemia and hypercholesterolemia were improved or normalized in this order. These laboratory data were improved or normalized more rapidly in the minimal change group than in the other groups. 3) Complete remission of the minimal change group by steroid therapy was obtained in twenty-nine of thirty-nine cases (74.4%) within half a year and in twenty-one of twenty-twenty-five cases (84%) after two years.
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