Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 23, Issue 1
Displaying 1-16 of 16 articles from this issue
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  • Studies on Oncogenetic Effect of N-Methyl-n′-nitro-N-nitrosoguanidine in Experimental Animals.
    Especially Producing Malignant Lymphoma in Praomys (Mastomys) natalensis
    MAKOTO KAWASAKI
    1977 Volume 23 Issue 1 Pages 44-57
    Published: March 10, 1977
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.23.44
    JOURNAL FREE ACCESS
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    Sugimura et al (1967, 1970, 1971) made it possible to produce a gastric cancer in rats or dogs by oral administration of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). In their studies it was found that this compound was able to produce various kinds of tumors not only in the stomach but also in other organs. Thus it becomes a subject of the experimental oncology to investigate various derivatives of this compound as for the carcinogenetic effect on organs of different animals. Each species of experimental animals was known to show different response to the same derivative, changing in the ratio and site of the oncogenesis. The author studied the ratio and site of the oncogenesis of MNNG in various species of small animals : Wistar rat, golden hamster, dd/I mouse and praomys (mastomys) natalensis. MNNG was given as the solution of drink water to these animals. The remarkable differences in the tumor growth in each species were found. In the rats cancers were detected in high degree in the glandular stomach, and in the hamsters many sarcomas and a few cancers were demonstrated in the glandular stomach. However in the seven autopsied mice no cancer were found. This fact is the conspicuous contrast to the results of the other authors who had showed the strong carcinogenetic effect of MNNG on the esophagus and the duodenum of the mouse. In the experiment of the mastomys, they were divided into two groups : the one group consisted of one and a half month old animals and the other, of twelve month old ones. In about half cases of the autopsied mastomys in both groups, malignant lymphomas were verified in the mesenterium. In the older group an adenoma of the adrenal gland and a fibrosarcoma of the genital organ were found to be associated with malignant lymphoma of the mesenterium. From these results it should be emphasized that the oncogenetic effect of the derivative was markedly different according to the species of the experimental animals. Although MNNG was administed to these animals in the same solvent through the same route, lymphoma was detected in the most of the mastomys and cancer was produced in the other small animals.
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  • Role of Indole on the 2-Acetylaminofluorene Toxicity and Carcinogenisity in Rats and Hamsters.
    MICHIO MATSUMOTO
    1977 Volume 23 Issue 1 Pages 58-80
    Published: March 10, 1977
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.23.58
    JOURNAL FREE ACCESS
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    Indole is known to suppress the hapatotoxicity and carcinogenicity of 2-acetylaminoflorene in rats and hamsters. On the other hand, indole enhances the urinary bladder carcino-genesis of 2-acetylaminofluorene in rats and hamster by coadministration of 2-acetylaminofluorene and indole. 1) The role of indole in urinary bladder carcinogenesis of 2-acetylaminafluorene was critically evaluated in hamsters. To avoid the influence of nutritional factors on the cancer incidence, the hamsters were pair fad for 8, 10 and 12 months. Addition of indole to the 2-acetylaminofluorene diet resulted in a higher incidence of urinary bladder carcinomas in both males and females of hamsters (p<0.05 in both sexes). Indole definitely increased the cancer incidence of urinary bladder an 8 months (p<0.05). Also significantly different was the cancer incidence between males and females irrespective of the diet administrated (p<0.05). Indole did not alter the urinary output N-hydroxy-2-acetylaminofluorene in male hamsters. 2) To elucidate the mechanism of protective role of indole on 2-acetylaminofluorene hepatotoxicity, 2 experiments were conducted using young male rats. In the experiment 2) -A, 24 hr biliary excretion of N-hydroxy-2-acetylaminofluoreneglucuronide was mesured after 2 and 4 weeks of dietary administration of 0.03% 2-acetylaminofluorene with or witout 1.6% indole. The amount of (9-14C) N-hydroxy-2-acetylaminofluorene excreted as the glucuronide following a single intraperitoneal injection of (9-14C) 2-acetylaminofluorene was lower in animals fed 2-acetylaminofluorene and indole after 2 weeks, as compared with those fed 2-acetylaminofluorene alone [1.5±1.2% versus 19 ± 3.6 S.E., (p<0.05)]. After 4 weeks of 2-acetylaminofluorene administration without indole, the bilirry excretion fell to 4.8±2.1%. This was also significantly higher than that in the animals fed both 2-acetylaminofluorene and indole [1.8±1.2% (p<0.05)]. The suppressive role of indole on the conjugate excretion was also reflected on a decreased biliary excretion of all (9-14C) 2-acetylaminofluorene metabolites in animals treated with indole alone. In the experiment 2) -B, the protective action of indole was assessed by the mortality rate following daily intraperitoneal injections of N-hydroxy-2-acetylaminofluorene and Na2 SO4 solution. Sodium sulfate increased the hepatotoxicity of N-hydroxy-2-acetylaminofluorene. On the contrary, indole suppressed the toxicity of N-hydroxy-2-acetylaminofluorene even in the presesce of Na2SO4. This protective role of indole was partially overcome only when excessive sulfate was coadministrated. These results indicate that indole suppresses the biliary excretion of the O-glucuronide of N-hydroxy-2-acetylaminofluorene during the initial exposure of the animals to the carcinogen, possibly reflectingt he decreased N-hydroxy-2-acetylaminofluorene formation. Indole also modifies the metabolism of 2-acetylaminofluorene following N-hydroxy-2-acetylaminofluorene, perhaps effecting the activation of N-hydroxy-2-acetylaminofluorene, depending upon the concentration of sulfate available.
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  • Vagina Formation and Morphological Changes of the Male Urogenital Tract in the Cyproterone Acetate-induced Feminized Male Mice.
    YOSHlHIDE SUZUKI
    1977 Volume 23 Issue 1 Pages 81-91
    Published: March 10, 1977
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.23.81
    JOURNAL FREE ACCESS
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    In order to study histogenesis of the vaginal anlage in the feminized male fetuses, male fetuses which were obtained from pregnant mice treated with 6 mg of cyproterene acetate (CA) from day 14 of pregnancy were sacrificed at different fetal ages and examined histologically. The formation of vaginal anlage was evident at day 18 of pregnancy in female and CA-treated male fetuses. In the feminized male fetuses, the most part of the Müllerian duct degenerated and only the fused part of Müllerian duct which was close to the urogenital sinus remained. At the same time, the formation of the vaginal plate from the dorsal wall of the urogenital sinus occurred. Thus, the origin of vaginal anlage of CA-induced feminized males seemed to be similar to that of the female; the cranial part originated from the fused Müllerian duct and the caudal part arising from the urogenital sinus. In order to study the dose-effects of CA on the development of the male reproductive tracts and the vaginal anlage in male offsprings, 1, 3, or 6 mg of CA was injected to pregnant mothers from days 14 to 20 of pregnancy. In CA-treated (feminized) males, the development of bulbourethral gland, coagulating gland and prostate were inhibited under the CA influence. The degree of inhibition of these organs by CA treatment was highly correlated with the dosage of CA. The vaginal plate formed from the urogenital sinus in male receiving 6 mg of CA showed the almost same shape as the vaginal plate of newborn females. However, with 3 mg of CA, the formation of the vaginal plate was markedly modified. In males exposed to 1 mg of CA, further modification was observed and the formation of vaginal plate was incomplete. These results suggest the possible inhibitory and stimulatory roles of androgen in the differentiation of vagina and male reproductive tract.
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  • Adrenal Invasion From Renal Carcinoma with Emphasis on Selective Angiography
    --Discussion on Abdominal Angiography--
    TOSHIO KOIDE, KIYOSHI KINEBUCHI
    1977 Volume 23 Issue 1 Pages 92-97
    Published: March 10, 1977
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.23.92
    JOURNAL FREE ACCESS
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    In order to delineate extention and spreading mode of tumors, observation of accessory and abnomal arteries by angiography is highly important to clinical practice. In patients with renal carcinomas, presence of adrenal metastasis strongly effects on the decision of operation and further management. The present patient with renal carcinoma is a 57 year old Japanese woman. An abdominal angiography revealed the presence of inferior adrenal artery, capsular artery, superior adrenal artery and branches of right hepatic artery as accessory arteries. These angiographical findings imply intensive spread of the tumorous and then adhesion to adjacent organs such as liver and adrenal gland. In addition, the superior convexity of the capsular artery at the upper pole of the right kidney was demonstrated, implying cranial vector of the tumor extention. Operative findings confirmed these angiographical findings of the tumor and its metastasis. Other several X-ray films of the subtraction are presented. In conclusion, the authors would emphasize that a detailed analysis of feeding arteries is remarkably valuable to elucidate adrenal involvement of renal carcinoma.
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  • Remarks on the role and Function of psychiatric social worker in psychiatric Care, Part 1.
    MUTSUKO MATSUBARA
    1977 Volume 23 Issue 1 Pages 98-104
    Published: March 10, 1977
    Released on J-STAGE: November 22, 2014
    DOIhttps://doi.org/10.14789/pjmj.23.98
    JOURNAL FREE ACCESS
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