Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 21, Issue 1
Displaying 1-12 of 12 articles from this issue
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Contents
  • Diagnosis and Surgical Treatment of Early Gastric Cancer classified to the Superficial Spreading Type.
    AKIRA YASUI, YOSHINARI HIRASE, YUTAKA ICHINOSE, MASAFUSA MIYAKE, MITSU ...
    1975 Volume 21 Issue 1 Pages 36-41
    Published: March 10, 1975
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.21.36
    JOURNAL FREE ACCESS
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    These five cases with S. S. C. of early gastric cancer are presented emphasizing that in order to get good results the preoperative examinations should be done repeatedly in detail around (a cancer lesion appearing as) an erosive part, ulcer or lowcer elevated lesion of the gastric wall by x-ray and endoscopic examinations especially biopsy and cytological examination. It is extremely important that in the early stage of gastric cancer correct diagnosis is made and the region of resection by operation is correctly determined. The surgeon should be accustomed to determine the borders of the gastric resection by the hardness of the region with cancerous infiltration. However early gastric cancer is usually not so hard. The extent of the cancerous lesion on the oral side should be decided by macroscopical observation following gastrotomy or by endoscopical biopsy before operation, especially in S. S. C. The authors have found S. S. C. in 20% of early gastric cancer. Moreover we have also reported in the author's papers that multiple gastric cancer were found in about 4% of cases with early gastric cancer. In the case with multiple gastric cancers the determination of the oral side for the resection should be decided very carefully. Therefore it is extremely important for surgeons to become skillful in preoperative diagnosis and in the macroscopic inspection on mucosal changes and on surface of the resected stomach in gastrotomy. This ability should be fully utilized in deciding the correct line of gastric resection in operation.
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  • A Dynamic Study on the Lumbar Intervertebral Disc
    TAKAMITSU KOBAYASHI
    1975 Volume 21 Issue 1 Pages 42-52
    Published: March 10, 1975
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.21.42
    JOURNAL FREE ACCESS
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    The intradiscal pressure and the shrinkage of the disc were measured under the various compressive load, using a needle-type pressure transducer (Toyota Koki). Fifty-six cadavaric fresh human discs were used in the experiment. The following Results were obtained : 1. The relationship between the load and the msrphological change of the disc was found to be in a parabolic curve. 2. The load within 150 kg and the intradiscal pressure were showed to be in a linear relationship. 3. The stress distribution against the compressive load was calculated to be 55% in the nucleus pulposus, 45% in the annulus fibrosus and zero in the posterior segment. 4. The specimen with a posterior metal plate fixation showed the shrinkage of 30-40% less than the specimen with the non-fixation.
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  • Flexibility of the Conformation of the Active Site of Myosin-ATPase Observed from the Reactivity of Thiol Groups
    KENZI TAKAMORI
    1975 Volume 21 Issue 1 Pages 53-65
    Published: March 10, 1975
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.21.53
    JOURNAL FREE ACCESS
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    Conformational changes around the active site of myosin-ATPase were studied from the reactivity of specific sulfhydryl groups (S1 and S2) to maleimide derivatives, N-ethylmaleimide (NEM), N- (4-methoxy-2-benzimidazolyl methyl) maleimide (MBM), N- (p- (2-benzimidazolyl) phenyl) maleimide (BIPM) and N- (4-dimethylamino-3, 5-dinitrophenyl) maleimide (DDPM). 1. Apparent second order rate constants of the reaction of maleimide derivatives to a low molecular model compound, N-acethylcysteine (NAC), were BIPM>>NEM>>DDPM>MBM in order. 2. S1 and S2 of myosin reacted with all maleimide derivatives used, but the patterns of change in ATPase activity were different each other. S1 showed higher reactivity than the SH group of NAC, and the apparent reaction rate to NEM was about 700 times greater than that of S2. Reagents with aromatic side chain, especially BIPM, showed relatively higher reactivity to S2 than S1. 3. S1 has “abnormal” dissociation constant, 6.28 as the pka value, as compared to that of cysteine thiol, higher than 9.0. 4. It was confirmed from the reactivity of S2 and its susceptibility to nucleotide that S2 was in buried state. 5. The reactivity of S1 was increased in the presence of nucleotides, its order being ADP>ATP. 6. From the values of pka of S1 the active site of myosin was deduced to have different conformations depending on pH with the critical one around 7.0. 7. The addition of Mg2+-ATP to the S1-blocked myosin system did not alter the total amount of thiols reacted with BIPM, but selectively increased that of S2 to a great extent. 8. Arrhenius plot of the reaction rate of S2 was biphasic with a bending point around 15°C. In the presence of Mg2+-ATP, the bending completely disappeared. On the basis of the results obtained, the state of S1 and S2 in the myosin molecule and the flexibility of the conformation of the active site of myosin-ATPase were discussed.
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