Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 21, Issue 3
Displaying 1-13 of 13 articles from this issue
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Contents
  • A Pathohistological Study of Cystic Medionecrosis of the Great Vessels in Marfan Syndrome with a Special Reference to Histochemical Analysis of Acid Mucopolysaccharides Using Enzymatic Digestion Method
    NOBUTANE HAZATO
    1975 Volume 21 Issue 3 Pages 263-275
    Published: September 10, 1975
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.21.263
    JOURNAL FREE ACCESS
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    Behaviors of acid mucopolysaccharides (aMPS) in cystic medionecrosis of the great vessels in 6 cases of Marfan syndrome, were histochemically studied in comparison with arteriosclerotic aneurysms (in 3 cases of dissecting aneurysms and 2 cases of non-dissecting aneurysms), syphilitic aneurysms (in 3 cases), pulmonary hypertension (in 2 cases of chronic cor pulmonale, 2 cases of mitral valvular diseases and 2 cases of primary pulmonary hypertension), and 20 cases of control subjects with ageranging from 2 years to 89 years old. The analysis was made by digestion method using enzymes such as testicular hyaluronidase, streptomyces hyaluronidase and chondroitinase AC and ABC. The results were as follows. 1) The aortas in Marfan syndrome had spindle shaped aneurysm, dissecting aneurysm, and aortic valvular insufficiency macroscopically in all cases and microscopically showed high grade of cystic medionecrosis. The pulmonary arteries in Marfan syndrome showed macroscopically no such lesions, but microscopically showed some cystic medionecrosis in all cases. Variety of the cystic medionecrosis in the pulmonary arteries depended on the grade of hemodynamic load on them. 2) Behaviors of aMPS in the aortas and pulmonary arteries in Marfan srndrome were completely identical in each case, though the main components of aMPS were different case by case. The aMPS in the great vessels of Marfan syndrome consisted of hyaluronic acid or chondroitin sulfate AC as major component, and of chondroitin sulfate B as decreased or minor component in all cases. 3) The grade of cystic medionecrosis of the aortas in control subjects and cases with pulmonary hypertension was generally low except the old with hypertension. 4) In a part of the cases with dissecting and saccular aneurysms due to arteriosclerosis and syphilis, the grade of cystic medionecrosis was considerably high and the aMPS with various fractions (chondroitin sulfate ABC, hyaluronic acid and the others) was deposited in the portion of cystic medionecrosis in the aortas. 5) The metabolism of aMPS in smooth muscle cells in the great vessels of Marfan syndrome might be considered to be congenitally different from that of the other diseases, and the great vessels seemed to be abiotrophically exhausted through hemodynamic overload and to be followed by cystic medionecrosis.
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  • RNA Synthesis of Lymphocytes of Human Peripheral Blood Stimulated with Phytohemagglutinin (PHA) and Its Clinical Evaluation in Various Diseases.
    YOSHIHISA WAKABAYASHI
    1975 Volume 21 Issue 3 Pages 276-285
    Published: September 10, 1975
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.21.276
    JOURNAL FREE ACCESS
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    We have been studying about cytochemical studies, especialy nucleic acids synthesis and immunoglobulin synthesis, in human blood lymphocytes. Some results of these studies had been reported in various papers. This paper is one of the same series. In this investigation, the clinical evaluation of RNA synthesis of lymphocytes in various diseases (autoimmune, hematological, hepatic, infectious, and other diseases) stimulated with PHA was discussed. The results are as follows: In autoimmune diseases, RNA synthesis of lymphocytes was markedly depressed, especially in systemic lupus erythematosus. But, in remmission, it was recovered almost to normal range. In complete form of Behcet's syndrome RNA synthesis was depressed, but not in incomplete form. In sarcoidosis, all cases indicated depressed RNA synthesis, but, in remission, it was recovered. At severe stage of sarcoidosis, lymphocytes stimulated with PPD indicated poor RNA synthesis, but at remission stage, it was recovered, and these experimental evidences were parallel with clinical tuberculin reactions. In infectious mononucleosis, RNA synthesis of lymphocytes stimulated with PHA was suppressed completely. In acute hepatitis and hepatic cirrhosis, RNA synthesis of lymphocytes stimulated with PHA was suppressed markedly, although, in chronic hepatitis, it was stimulated strongly. In other diseases with bacterial infection, it was markedly stimulated in all cases.
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  • Present Status and Future Aspects of Cryosurgery
    TADAMITSU YAMAZAKI, HIROO YOKOTA, YUJI FUJII
    1975 Volume 21 Issue 3 Pages 286-291
    Published: September 10, 1975
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.21.286
    JOURNAL FREE ACCESS
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    Experimental cryosurgery on 9 cases of the dogs and one human clinical case were described. Results obtained showed the enough possiblity of the method for the surgery of the malignant tumors. By the method the surgical operation will be performed characteristically with lesser influences in the following aspects, i.e., in bleeding, pain the inframatroy reaction and the malignant metastasis during anf after the invation and it will be carried out with only easy control in even the poor risk cases.
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