Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 46, Issue 4
Displaying 1-15 of 15 articles from this issue
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Contents
  • Gene therapy
    -The current and future status-
    YASUHIRO SETOGUCHI
    2001 Volume 46 Issue 4 Pages 423-442
    Published: May 30, 2001
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.46.423
    JOURNAL FREE ACCESS
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    Gene therapy is a novel approach to treat, cure, or ultimately prevent disease by changing the expression of a person's genes. Gene therapy is in its infancy, and current gene therapy is primarily experimental, with most human clinical trials only in the research stages. During the past decade, clinical trials of gene therapy have been performed in about three thousand patients in the USA. Most of these clinical studies reported therapeutic efficacy results that fall for short of initial expectations. However, recent improvements in gene transduction may be efficacious in gene therapy for some diseases. Moreover, more recent advances in genetic technology may make gene therapy available for cell therapy or tissue engineering using stem cells.
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  • Evaluation of neutrophil functions in rat experimental cancer cachexia model
    SEIYA HOSODA
    2001 Volume 46 Issue 4 Pages 443-452
    Published: May 30, 2001
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.46.443
    JOURNAL FREE ACCESS
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    Objective : Using a rat cancer cachexia model we evaluated the neutrophil functions in cancer-bearing conditions. Materials and methods : Cancer-bearing rats were produced by intraperitoneal inoculation of Yoshida AH -130. On days 1, 4, and 8 after tumor transplantation, peripheral blood and ascites were collected, and neutrophil functions and levels of TNF-α and IL-8 in ascites and blood were analyzed. Results : In cancer-bearing rats, the blood neutrophil count was increased, and the phagocytosis and reactive oxygen-producing activity of these cells were enhanced. In addition, the expression of Mac-1 (CD11b/CD18) on neutrophils was increased after tumor transplantation, whereas L-selectin expression was decreased. Interestingly, neutrophil migration was markedly suppressed in cachexia. Furthermore, TNF-α and IL-8 levels were elevated both in ascites and peripheral blood. Conclusion : In cancer cachexia, cytokine levels (IL-8 and TNF-a) were elevated, and neutrophil functions such as phagocytosis, reactive oxygen-production and the expression of adhesion molecules were activated. However, neutrophil migration was markedly suppressed.
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  • Linac-based Radiosurgery in Juntendo University
    YUTAKA NAOI, KEISUKE SASAI, YUOU IIZUKA, NARISUMI CHO, KANA ITOH, MASA ...
    2001 Volume 46 Issue 4 Pages 453-457
    Published: May 30, 2001
    Released on J-STAGE: November 12, 2014
    DOIhttps://doi.org/10.14789/pjmj.46.453
    JOURNAL FREE ACCESS
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    Linac-based radiosurgery has been used since October 1994 at Juntendo University Hospital, and a total of 215 patients were treated from 1994 to November 2000. Radiosurgery was predominantly used to treat cases of brain metastases and cerebral arterio-venous malformation (AVM). We report the systems and method of linac-based radiosurgery and a summary of the treated patients including those with brain metastases and cerebral AVM. Based on the results at our hospital, we consider that this treatment is very useful for cases of brain tumor and cerebral AVM, and that this system has much possibility for intra and extra cranial lesions.
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