1) オートラジオグラフにより, マウス皮膚へのL-histidine-2-C¹⁴, H³-tyrosine, H³-tryptophan, H³-asparticacidの取込みを観察した。
2) その結果, 上記アミノ酸の取込みは, それぞれ異なる分布を示した。即ち, C¹⁴-histidineは表皮顆粒層に, H³-tyrosineは体毛のkeratogenous zoneに, H³-tryptophanは表皮基底層及び有棘層に, H³-asparticacidは皮下脂肪組織にそれぞれ多く取込まれた。
3) C¹⁴-histidine, H³-tyrosineの表皮及び体毛における分布を比較し, 文献的考察を加え, 角化との関連について検討した。その結果, C¹⁴-histidineの顆粒層への取込みは, ケラチン以外の蛋白合成に関与し, 一方, H³-tyrosineは体毛の角化に何らかの役割を果たすことが推測された。H³-tryptophan, H³-asparticacidもそれぞれ特徴ある分布を示し, 皮膚のアミノ酸代謝には部位的特徴のあることがうかがわれた.start-page=221

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Epidermal melanocytes and Langerhans cells of normal human skin and vitiligo vulgaris were observed under an electron microscope. The results were as follows;
1) Inside inner nuclear membrane, nuclear substance in belt, about 600Å wide, is observed all around the nucleus. There are fibrous structures, well-developed rough-surfaced e. r., many groups of ribosomes (each consisting of several ribosomes) and, many vesicles in cytoplasm. The above are findings common to melanocytes and Langerhans cells. But while melanocytes have melanosomes and melanin granules, Langerhans cells have Birbeck's granules and lysosomes instead. Melanosome presumably originates in smooth-surfaced e. r., and Birbeck's granules in Golgi body. Birbeck's granule is elliptic, its long axis being 0.3μ, short axis 0.2μ and its width 300-400Å. Some granules have egg-shaped bulges respectively at one end.
2) In the basal cell layer of vitiliginous epidermis, dendritic cells of the same structure as Langerhans cells and dendritic cells containing fewer organelles are observed. The latter are regarded as melanocytes that have lost melanin productivity.
3) Langerhans cells are not mere effete cells of melanocytes, but are still carrying on protein synthesis. DOPA reaction test has proved Langerhans cells don't produce DOPA-melanin in any organelle of its cytoplasm. Consequently, Langerhans cells may well be called effete cells of melanocytes in respect of melanin productivity.
4) DOPA reaction test has proved only melanosomes and smooth surfaced e. r. have DOPA-melanin productivity in epidermal melanocytes.

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Two cases of pyoderma gangrenosum were reported: the one was 39-year-old male on back, the other was 4-month-old infant on bilateral axilla, groin, and side of neck.
The review of literature concerning the clinical and histo-pathological features, laboratory data, bacteriological studies, and pathogenesis of pyoderma gangrenosumin relation to its colitis ulcerosa were described.

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