A 20 year old male. At the end of June 1958, a painless nodule developed without preceeding trauma 3 cm. above the right external condyle. This nodule ulcerated with purulent discharge one to two months later. Similar nodules gradually appeared and increased in number and in April 1960, they extended from the right instep to the dorsum of the foot, which was edematous. The right inguinal lymph glands became swollen without pains since about May.
No marked changes were noted in the epidermis histologically, but grains were present here and there in the dermis. Infiltration by lymphocytes, polymorphonuclear leucocytes, epithelioid cells and plasma cells was noted around the grain. By culture of the purulent discharge, this case was diagnosed as Madura foot due to Nocardia asteroides (Eppinger).
As this organism was moderately sensitive to penicillin, erythromycin and canamycin, this case was treated with these antibiotics. The edematous swelling of the right instep subsided about one month after admission to the hospital.
Further observation and treatments are being done.

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The authors administered intravenously the cristalline essential aminoacids solusion to a case of systemic erythematodes (27 aged, wife), improving the clinical feature. especially for her dysproteinaemie.

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The periferal nerves of the skin were studied morphologically using various silver staining methods. Fresh sections of skin were required. For the normal skin, samples were taken from the surrounding region of tattoo of the abdomen, both arms and thighs of healthy males and females ranging in age from 17 to 42. For the pathological skin samples, biopsy specimens of the rash of both vesicular and dry stages of herpes zoster, skin of the depilated lesion and the surrounding region of alopecia areata, skin of the outer part of the forearm in the sclerotic stage of diffuse sclerodermia and the lesion in the chest of macular leprosy were selected. The skin samples were imbedded in paraffin and sectioned in various planes, perpendicular, diagonally and horizontally. Serial 20μ sections were made. The formic acid pretreatment silver stain of Suzuki, K. was mainly used and his other methods and the modified Winkelmann-Schmit silver stain method (quick method) were also used.
In the normal skin, protuberances composed of axoplasma only without neurofibrils were found in the sensory nerve fibers in the cylinder-cell layer of the epithelial follicular sheath at the neck of the hair follicle. A large periterminal-reticulum (Boeke) of sensory nerve including axoplasmatic and neurofibrinous anastomosis was found in the connective tissue follicular sheath.
Furthermore, a neuroplasmatic periterminal-reticulum (Boeke) without neurofibrils was found in the outer side of the cylinder-cell layer of the epithelial follicular sheath. This finding was observed with the simple silver stain method (Winkelmann-Schmit modified paraffin method). Similar findings were obtained in samples of skin from the abdomen, scalp and forearm with various Suzuki silver stain methods. It was found that the protuberances took many forms and pallisade-like, net-like and bar-like forms were observed.
In the pathological skin samples, there were atrophy of the neuroplasmatic protuberances and axoplasma of the sensory nerves in alopecia areata, destruction in herpes zoster, atrophic degeneration in macular leprosy and hypertrophy of the neuroplasmatic protuberance in diffuse sclerodermia.
Numerous vegetative nerve fibers were also found in the surrounding region of the hair follicle.
Vegetative nerve fibers, said to be destroyed easily in the smooth muscle, were found clearly using the above staining methods. Vegetative nerve fiber around the capillary in the sratum papillosum were connected within the musculus arrector pili. Delicate periterminalreticulum (Boeke), the vegetative nervous endform at one side of smooth musclar nucleus and interstitial cell in the root of musculus arrector pili were observed.

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The author studied histologically and histochemically the skin of the “KOGANBYO” (Lake side disease-chronic type).
At the same time, the author compared the skin changes not treated with those treated with the multivitamin
“Koganbyo”-chronic type is the characteristic dermatosis, whose fundamental changes are prominent parakeratosis and acanthosis accompanied with decreas or disappearance of melanine, vacuolic degeneration of prickle cells, pyknosis and deformatiDn of nucleus of prickle cells, edema and inflammatory cell reactions of cutis.
Histochemically, marked increasing of SH and RNA, fatty degeneration and the presence, of PAS positive substance were observed in the parakeratotic horny layer. The conspicuous augment of glycogen and RNA were recognized in the prickle cell layer.
As the result of the vitamin treatment for the patients of Koganbyo chronic type, the parakeratosis and acanthosis decreased and melanine appeared again or increased.
The perinuclear vacuolic degeneration of prickle cells, and pyknosis and deformation of the nucleus of prickle cells reduced by the vitamin treatment.
The keratohyalin granules appeared again or increased in quantity after the vitamin treatment.
The most conspicuous differences of histochemical findings of the skin of “Koganbyo” chronic type between before and after the vitamin treatment are the content of SH, glycogen, RNA, PAS positive substance and fat.
The SH, RNA and fat, which were present abundantly before the vitamin treatment in the parakeratotic horny layer and in the prinkle cell layer, decreased or disappeared after the vitamin treatment.
The PAS positive substance which exsisted in the parakeratotic horny layer and was not glycogen, disappeared completely by the vitamin treatment.
These facts above described indicate that the pathologic conditions of the skin of “Koganbyo”are greatly improved by the vitamin treatment and, at the same time, these facts mean that the cause of the “Koganbyo” chronic type is due to the certain vitamin deficiency.

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113 patients, employees of an Asbestos Plant, complaining of roughness of the manual skin were examined.
The roughness was commenced with an extreme gradual onset and aggravated in winter, and could be mitigated after a few days rest. Clinically, decrease in the sweating was observed on palms of the patients.
It seemed that the present symptom was not allergic in nature and simulated a progressive keratosis.

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1. The total vitamin C content of the skin in rabbits were unchanged for 5 hours following the administration of ACTH or cortisone, but was markedly decreased for 3-24 hours following the administration of DOCA. The total vitamin C content of the blood was not effected by cortisone, but was markedly decreased following the administration of ACTH or DOCA.
Cortisone or DOCA gave no effect on the water content of the skin, while they increased iodine acid value in the blood for 3-24 hours.
2. A schematic representation on the pathogenesis of diffuse scleroderma was given using such factors as; (1) preceeding persistent hypoproteinemia, (2) prolonged exposure to stress, (3) hyperactivation of the hypophysis-adrenocortical system, especially DOCA dominance, (4) increased protein metabolism, (5) consumption of vitamin C in the skin and disturbance in the enzymatic system, and (6) disturbed connective tissue state.

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5-Methyl-3-sulfanilamido-isoxazole was administered orally to 24 cases of pyodermia and others. Almost all of the cases were cured. Staphylococcus aureus were isolated from every case of celluitis, and carbuncle, which were responded very well by the treatment.
In 27 cases of pyodermia, 1/2 of the oral dose was given intravenously or subcutaneously. This gave about the same result as with oral therapy alone. Nausea and vomiting as the side effect were noted in two cases.

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Fulvistatin was applied orally to 12 cases of dermatomycosis.
(1) Trichophytia pompholyciformis. 5 cases were given 1g/day, and 4 cases were effective. 1-2 weeks treatment was necessary to see the sign of effectiveness, and 2-4 weeks necessary for cure.
(2) Eczema marginatum. 2 cases were treated by 1g/day, and from 15 to 18 days treatment was necessary for cure. It seems lesser dosage may be effective.
(3) Onychomycosis. 5 cases were treated by 1g/day successfully. 1 case wasc ured. Recommended daily dosage may be reduced to 0.75g., after sign of effectiveness is seen.
(4) Side effect. Gastrointestinal disorder and eruption were seen in one case.

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カバーマークについて実地に詳しく知りたいという考えが前からあつたのであるが, 皮泌科臨床談話会24回例会に於て当日の出席者18名がオリリー会社を訪れ, 直接見聞する機会を得, 印象のさめないうちに直ちに座談会を開いた. 皮膚科医として参考になる点も多く, 又一般に直接行つて見学する時間的余裕がなかなか無いと思われるので, その時の記録を掲載して頂く事にした.

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