Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 24, Issue 3
Displaying 1-15 of 15 articles from this issue
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Contents
  • Effect of Drugs on Cultured Liver Cells
    MASANORI IWADARE
    1978 Volume 24 Issue 3 Pages 307-313
    Published: September 10, 1978
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.24.307
    JOURNAL FREE ACCESS
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    Epithelial culture was established from fetal rat liver. The epithelial like cells are maintained their morphology for up to 350 days of continuous culture. The toxicity of some drugs were determined using this strained cell. (1) This strained cells responded sensitively to the carcinogen or anti-tumor agents. (2) The strained cells could be expect to be a model system of toxicological examination. (3) The strained epithelial cells have stable growth rate and the number of chromosomes were 2n=46.
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  • Clinical and Roentgenological Study on Colo-rectal Diseases with Fine Ulcerative Lesions
    KANJI ODA
    1978 Volume 24 Issue 3 Pages 314-331
    Published: September 10, 1978
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.24.314
    JOURNAL FREE ACCESS
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    In recent 6 years X-ray examinations of the colon have been performed on 5,240 patients with colorectal diseases with fine ulcerative lesions using barium enema by the modified Brown's method. In the present paper, clinical and roentgenological findings of fine ulcerative lesions detected in those cases were shown comparing with the findings of colonoscopy and biopsy. The following results were obtained. (1) It was confirmed that so-called fine network pattern, which is thought to be the minimum roentgenographic unit, really corresponded to innominate grooves on the surface of the large bowel according to the comprative studies of roentgenological, macroscopic and microscopic findings of the resected colon. In X-ray examinations, the appearrance rate of the fine network pattern closely corelated to the length of the colon. The fine network pattern altered due to the degree of distension, distorsion or torsion of the bowel. The fine network pattern were more clearly demonstrated in the patients given a set of packed special food than in those just given the restricted diet. (2) In ulcerative colitis, ulcers were classified into five groups according to the size. The fine network pattern and the size of the ulcer indicated the stage of ulcerative colitis. The stage of ulcerative colitis was clearly decided in 61% of the cases showing fine network pattern, but in the remaining 39%, biopsy by colonoscopy was neccessary to decide the stage. Reappearance of the fine network pattern on the double contrast view was noted in only 10% of the patients with ulcerative colitis who were clinically in remission during follow-up period. No relation was observed in active stage between reappearance of the fine network pattern and the grade of ulceration. The distribution, number, size, depth and form of the ulcer, the change of the surrounding mucosa and covering folds should be analyzed for a differential diagnosis of colo-rectal diseases with ulcerative lesions. (3) Proctitis could be classified roentgenologically into 3 groups, namely rough type, granular type and spotty type. In rough type, the mucosa appeared to be awfully inflammatory bleeding in all cases. It was difficult to differenciate proctitis of this type from ulcerative colitis localized in the rectum. In granular type of proctitis, a histological feature showed hyperplasia of lymph follicles of the rectal wall.
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  • Clinical and Radiologicol Studies of Percutaneous Transhepatic Cholangiography
    AKIRA KUROSAWA
    1978 Volume 24 Issue 3 Pages 332-353
    Published: September 10, 1978
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.24.332
    JOURNAL FREE ACCESS
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    Percutaneous Transhepatic Cholangigraphy (PTC) is an extremely useful tool for the assessment of diseases of the biliary tract and differential diagnosis of jaundice. Using fine needle (OD : 0.7mm, Length : 18cm with stylet) PTC has been performed in 806 patientrs. The procedure was successful in 206 out of 208 patients with the dilated intrahepatic bile ducts of more than 7mm in diameter (99%), and in 514 out of 598 of those with nondilated intrahepatic bile ducts (85%). Complications which required surgical intervention occured only in 2 cases (0.2%), Puncture was performed from the right flank mostly at the level of 7th or 8th intercostal space. Puncture site and direction of needle were evaluated according to the anatomical position of intrahepatic bile ducts and gallbladder. In order to minimize the complication of PTC, most important factors are not to puncture extrahepatic bile ducts and neighboring organs. In cases with the dilated bile ducts, puncture of intrahepatic bile ducts is easily achieved, however, in cases with non-dilated bile ducts visualization of biliary tree is not always successful at a first puncture. Relation between the number of puncture and complications is not increased by repeated puncture. Only in 2 cases bile peritonitis was developed after PTC and surgical operation was necessary. In these 2 cases, the gallbladder was punctured because of erroneous setting of puncture site and inadequate direction of the needle. Sixty four cases out of 310 cases had the complication of slight abdominal pain or the fall of blood presure (20.6%). In cases with the bile duct stones complications occured most frequently. The diagnostic efficacy of PTC was estimated in 41 cases with obstructive jaundice. Point of obstruction was determined in all cases and diagnostic accuracy was increased by 17%. In comparison with angiography, PTC is superior in assessing the point of obstruction and angiography is useful in diagnosing the extent and the resectability of the malignant lesion which caused obstructive jaundice. With combination of PTC and angiography, it is possible to accurately diagnose the bile duct lesion, extent and resectability of malignant lesion. It is concluded that PTC is a quite safe method and should be applied at an early clinical course in patient with suspected biliary tract disorders and obstructive jaundice. Bile drainage after PTC for the patients with obstructive jaundice is highly effective to reduce jaundice and to improve general status. PTC is applicable not only for the diagnosis but also for the treatment of jaundiced patients.
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