Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 38, Issue 3
Displaying 1-20 of 20 articles from this issue
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Contents
  • Changes in event-relatad potentials during the course of schizophrenia
    HIDEO FUMIMOTO
    1992 Volume 38 Issue 3 Pages 380-392
    Published: October 20, 1992
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.38.380
    JOURNAL FREE ACCESS
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    In 10 patients with schizophrenia diagnosed by the DSM III-R, we repeatedly recorded the Event-Related Potentials (ERP) based on the odd-ball task, and estimated in great detail their clinical symptoms by using the Brief Psychiatry Rating Scale (BPRS) and the Score for the Assessment of Negative Symptoms (SANS) from the time in which psychotropic drugs were not taken to the time of their remission. Then I longitudinally evaluated the changes of N100 and P300 component during the course of schizophrenia. In patients with catatonic type 2 and paranoid type 2, the P300 amplitude tended to be augumented with the remission of their symptoms, whereas in patients with disorganized type 3 and residual type 3, the changes in P300 amplitude were mostly low without having a fixed relation with the change of symptoms. Also, in the intermediate to low level group of social adaptation as compared to high level groups, the P300 component frequently appeared in the ERP when non-target stimulation was made. Also in the lowest level group, the P300 component was not observed at the stimulation of either the target or non-target. In the cognitive disorder of schizophrenia, therapeutic responsibility was high in the catatonic type and paranoid type whereas in the disorganized type and residual type there was a thrapy-resistant factor in which the pathological state was thought to be different from the former types. And from the evaluation of P300 when non-target stimulation was made, the disorganizing degree of cognitive structures was suggested to affect the social adaptation level.
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  • Follow up studies of human papilloma virus infection in cervical dysplasia
    SUSUMU HASEGAWA, HIROSHI UTSUNO, KAZUHiSA ISHI
    1992 Volume 38 Issue 3 Pages 393-400
    Published: October 20, 1992
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.38.393
    JOURNAL FREE ACCESS
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    HPV-DNA was detected in 48 (14.2%) out of 339 subjects screened for human papilloma virus (HPV) in the cervical region. HPV type and clinical manifestations were determined and cytological, colposcopic, and histological studies were continued in 16 of these cases in which dysplasia was noted and long-term observation for periods of at least one year was possible. HPV DNA was detected by Southern blotting (SB), dot blotting, and in situ hybridization (ISH). In the low-risk grpups infected by types 6 and 11, the viral DNA infected by types 6 and 11 (the low risk group) was detected almost entirely from tissue affected by chronic cervicitis or from cervical intraepithelial neoplasms (CIN I or II). Among the 6 cases of CIN I such that follow-up observation was possible, persistence was noted in 2 cases, regression in 2 cases, and progression in none. On the other hand, in the high-risk groups infected by types 16, 18, 31, 33, or 35, the virus was detected in various lesions independently of the stage of neoplastic development, varying from benign to malignant. Among the cases in the high-risk group infected by types 16 or 18, long-term observation was possible in 7 cases, 4 of which displayed persistence, 1 regression and 2 progression, with both of the latter cases displaying development into squamous cell carcinoma. In the intermediate risk group infected by types 31, 33, or 35, follow-up observation was possible in 3 cases, with 2 displaying regression and 1 displaying progression. Although HPV alone appears unlikely to constitute the etiologic agent in cervical carcinoma, the results of these long-term observations indicated that types 16 and 18 are intimately involved in the carcinogenetic process.
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  • Aflatoxin detection in rabbit tissues using orally-given aflatoxin and Aspergillus infection
    MAKIKO MATSUMURA
    1992 Volume 38 Issue 3 Pages 401-406
    Published: October 20, 1992
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.38.401
    JOURNAL FREE ACCESS
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    In Japan today, aflatoxicosis in humans does not occur through food consumption. However, the possibility that animal feed is contaminated by aflatoxin (AF) -producing strains, still remains and from the viewpoint of the food chain, is a very important problem. For this reason, the transfer to and accumulation in rabbit tissues was examined, with one case given AF orally, and another case infected by AF-producing strains. AF was not observed in either of the rabbit tissues. However, kojic acid, which is one of its metabolites, was found in several strains. These findings suggest that closer attention should be paid to these metabolites.
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  • Isolation and characterization of aortic endothelial cells from spontaneously hypertensive rats (SHR)
    SHINJI SUZUKI, SEIGO UEDA
    1992 Volume 38 Issue 3 Pages 407-417
    Published: October 20, 1992
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.38.407
    JOURNAL FREE ACCESS
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    Endothelial dependent relaxation was recently reported to be decreased in SHR, which suggests the dysfunction of endothelial cells. To clarify the functional alteration of endothelial cells, we cultured endothelial cells from rat thoracic aorta, and analyzed the difference of cellular structure and receptor signaling in the presence of bradykinin (BK) between SHR and normotensive Wistar Kyoto rats (WKY). Intracellular free Ca2+ ([Ca2+] i), IP 3 and PG-I2 were measured using an image analyzer (Argus-100 CA, Hamamatsu photonics) with fura-2/AM, radioligand 3H-IP3 and 125I-6-keto PG-F1α, respectively.There was no difference either in cellular structure and in the BK-receptor, (Bmax = 266±18 vs 254±20 fmol/106cells, Kd = 0.39±0.02 vs 0.04±0.03nM) between SHR and WKY, respectively. However, 10-9M to 10-7M BK increased [Ca2+] i by 2.5 to 5.6 fold in SHR compared with [Ca2+] i in WKY (p<0.05 n = 8). Since EGTA failed to give higher [Ca2+] i in SHR, elevation of [Ca2+] i appeared to be brought about by Ca2+ influx via the cytoplasmic membrane in SHR rather than intracellular Ca2+ release from internal stores. SHR also showed higher elevation in IP3 by 1.2 to 1.6 fold compared with those of WKY at a concentration of 10-9 M to 10-7 M BK (p<0.05 vs WKY). This indicates that the activity of PL-C was enhanced in SHR compared with that of WKY. By contrast, the release of. PG-I2 from the endothelial cells was diminished in SHR by 0.4folds compared with that of WKY (p<0.05 vs WKY). Thus, despite the lack of a difference in cellular structure and BK receptor kinetics between SHR and WKY, cultured endothelial cells from SHR showed a stronger response in [Ca2+] i and IP3, and diminished response in PG-I2 in the presence of BK than the endothelial cells from WKY. These findings indicate that endothelial cells from SHR are biochemically different in culture from those of WKY. Such cellular alteration may play a role in endothelial-related vascular physiology in hypertension.
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  • Intracorporeal dynamics, safety and clinical results of repeated intraperitoneal cisplatin (CDDP) administration in treating malignant ovarian tumors
    TAKESHI IWASA, NAOYUKI USUI, MASAAKI SUZUKI, MICHIO TAKADA
    1992 Volume 38 Issue 3 Pages 418-427
    Published: October 20, 1992
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.38.418
    JOURNAL FREE ACCESS
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    To determine the value of repeated intraperitoneal cisplatin (CDDP) administration in treating malignant ovarian tumor (ip treatment), we studied the intracorporeal dynamics and tissue concentrations of CDDP as well as its safety and clinical effects in 29 cases. The blood concentration of total-Pt showed higher preadministration levels with the increase in the number of administrations, The difference continued to increase at the same rate for 24 to 72 hours after administration. On the other hand, free-Pt was not detected in the blood before each administration even after repeated administrations, but showed relatively high levels immediately after the ip treatment up to the 2nd hour. Also the changes in free-Pt concentration in the ascites showed a pattern similar to that in the blood. On initial administration of CDDP, the total-Pt concentration in the ovarian tumor tissue was 0.19-0.76, μg/g in iv. 1.26-1.84, μg/g in ip, and 0.89-4.85 μg/g in ia. The total-Pt concentration in the ovarian tumor tissue following repeated ip treatments tended to be higher than that after the first ip treatment. After 10 or more repeated ip treatment, no tendency of aggravation in renal function was observed. The bacterial detection rate by an indwelling intraperioneal tube was 40.5% (15/47), and almost all isolated bacteria were CNS. A slight increase in the WBC was recognized in 2 cases. The efficacy rate in stage III ovarian carcinoma was 8 out of 11 cases (73%). Free-Pt showed continuously higher levels in the blood and ascites, and there were no safety problems, the clinical effect being excellent. These findings indicate that repeated intraperitonial CDDP administration is useful in treating malignant ovarian tumor.
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