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Volume 44, Issue 9
Displaying 1-4 of 4 articles from this issue
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Sutemi OKA1969 Volume 44 Issue 9 Pages 251-258
Published: 1969
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSAn attempt was made to predict the time when tuberculosis death rate in Japan becomes as low as 2 to 4 per 100, 000 as seen in Europe and USA. The prediction will certainly be of great help for the future study of establishing countermeasures against tuberculosis. A statistical analysis was made on the annual death rate of 14 countries from which reliable figures until 1964 are available. Tuberculosis death rate of the above 14 countries showed a pattern of normal distribution.
It was found that tuberculosis death rate decreases in a form of a monotonous function. The validity of approximate equations for the determination of tuberculosis death rate was confirmed by comparing the theoretical values with the actually observed figures.
Statistical analyses thus conducted indicated that tuberculosis death rate will become approximately 3 per 100, 000 around 1980, if the serious factors such as war which might influence the declining trend of tuberculosis are excluded.View full abstractDownload PDF (1271K) -
Zenji HORAI1969 Volume 44 Issue 9 Pages 259-272
Published: 1969
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSPneumoconiosis is the disease resulting by the inhalation of dusts in the lung, and pulmonary tuberculosis is the disease involved by the infection of the tubercle bacilli in the lung.
It has been discussed that development of pulmonary tuberculosis is affected b y inhalation of silica dusts. Concerning the relationship of silicosis and pulmonary tuberculosis, it was reported that two types of “Complication form” and “Combination form” were observed pathologically by Prof. Husten. Since then, many reserches have been reported on the relationship of pneumoconiosis and tuberculosis.
It is well known that prognosis of the pneumoconiotuberculosis is not so good as that of the each disease.
In this paper, the pneumoconiotuberculosis was discussed epidemiorogically, clinically, pathologically and experimentally. In epidemiological aspect, the results of the mass survey in the factory of dust circumstances were stated. It was emphasized that complication of pneumoconiosis and pulmonary tuberculosis was much more detected. In the clinical and pathological aspects, the more severe complex lesion was often formed in the pneumoconiotuberculosis. And it was more resistant to medical treatment than simple tuberculosis. In the experimental aspect, cavity formation involving a great deal of caseous substances was often observed after the infusion of dust particles (free silica, talc, and kaolin) with tubercle bacilli. Much more tubercle bacilli were counted in the pneumoconiotuberculous lesion than in simple tuberculous lesion.
It is new ly recognized that pneumoconiotuberculosis is an important occupational respiratory disease. As pneumoconiotuberculosis is a difficult curable disease, it must be efficiently careful to treat pneumoconiotuberculosis.View full abstractDownload PDF (2546K) -
Kimio YASUHIRA1969 Volume 44 Issue 9 Pages 273-287
Published: 1969
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSIn consideration of the mechanism of formation of epithelioid granuloma, which is histologically characteristic of tuberculous lesions and some other diseases, a new category of allergic reactions, a superdelayed type of allergy, was proposed by this author at the Autumnal General Meeting of the Japanese Pathological Society in 1960 (Acta_ Path. Jap.10: 419). At that time it was reported that in only tuberculo-sensitized animals (rabbits and guinea pigs) an Arthus type of necrotizing lesion was induced by tuberculopolysaccharide fractions and a tuberculin type of monocytic granulation by tuberculo-protein fractions from tubercle bacilli some days after the pulmonary instillation of these fractions. In contrast to these early reactions, epithelioid granulomas were produced in the treated lungs of sensitized animals some weeks after the administration of bacterial lipoids; for example, Choucroun's sensitizing material, Yamamura's lipoprotein, Anderson's phosphatide A3, and Lederer's wax D. Therefore, the granulomaproducing reactions to these antigens were named “superdelayed type” because of the markedly delayed appearance of tissue reactions. In control animals, these lipoids also induced epithelioid granulomas two to three weeks later than in sensitized animals. This shows the ability of these fractions to sensitize treated animals with an interval of a couple of weeks. In any case, it was pointed out that epithelioid granuloma is induced by superdelayed allergic reaction to some lipoidal components of tubercle bacilli or related bacteria in sensitized animals.View full abstractDownload PDF (2838K) -
1969 Volume 44 Issue 9 Pages 289-307
Published: 1969
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (4767K)
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