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Volume 46, Issue 12
Displaying 1-5 of 5 articles from this issue
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Harukata BABA, Ryunosuke TAKAHASHI, Yo AZUMA1971 Volume 46 Issue 12 Pages 481-489
Published: 1971
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSResistant test was carried out by proportion method using 1% Ogawa medium and cork stop. The results were read usually 4 weeks after incubation, but when the colonies on the control are too small, reading was done after 6 weeks. Preservation for 4 weeks at 20-22°C brought the slight reduction of activity in the media containing 2 mcg or 5 mcg of RFP but no change was seen in the media of 10 mcg or more.
Sensitivity to 2 mcg, 5 mcg, 10 mcg, 20 m cg, 50 mcg, of RFP was studies in 112 human strains isolated from new cases, cases resistant to primary and or secondary drugs, 4 strains of M. kansasii and 5 non photochromogens isolated from the patients. All 5 strains of non photochromogens were completely resistant to 50 mcg. All the human strains and M. kansasii showed nearly the same sensitivity to RFP, and there were no strains which grow more than 20% of the control on 5 mcg and 1% on 10 mcg or more. However, measuring on 2 mcg level. the more the number of resistants drugs, the higher the sensitivity to RFP.View full abstractDownload PDF (2001K) -
III. Antituberculosis Activity of INH in Combination with PAS in vitro after Exposure to PASNobuo MAEKAWA, Michiyasu NAKANISHI, Mitsuru KAWAI, Hitoshi NAKAI, Nobu ...1971 Volume 46 Issue 12 Pages 491-492
Published: 1971
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSFor the purpose of evaluating the bactericidal activity of INH in combination with PAS against tubercle bacilli (H37Rv) ntituberculosis Activity of INH in Combination with PAS under the inadequate condition for the growth of tubercle bacilli, the experiment was made by exposing tubercle bacilli to PAS under the concentration of 1 mcg/ml and 10 mcg/ml before testing the bactericidal activity of INH and PAS.
According to the results obtained, the bactericidal activity of INH and PAS is remarkably lowered after exposure to PAS.View full abstractDownload PDF (386K) -
II. Studies in vivoYoshiko OHTA1971 Volume 46 Issue 12 Pages 493-500
Published: 1971
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSTo evaluate the chemotherapeutic effects of antituberculosis agents against tubercle bacilli in the resting state, the author made in vivo experiment by using streptomycin (SM)-dependent strain of tubercle bacilli (18-b), cultivated under SM-starving condition.
Mice of dd-strain, infected intravenously by 18-b, are treate d with isoniazid (INH) alone or in combination with kanamycin (KM) and ethambutol EB for eight weeks. After treatment, colonies of tubercle bacilli recovered from lung and spleen of treated mice are recorded and compared with those of untreated mice and with mice infected with tubercle bacilli in normally growing state.
According to the results of this experiment, chemotherapeutic effects of antituberculosis agents such as INH, KM and EB were hardly observed against SM-dependent strain of tubercle bacilli (18-b) in the resting state under SM-starving condition of mice.View full abstractDownload PDF (1882K) -
Report I. The Method and the Coverage of the SurveyKazuro KIRARA1971 Volume 46 Issue 12 Pages 501-506
Published: 1971
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSFollow-up surveys were made in 1964 and 1968 on pulmonary tuberculosis patients found by the tuberculosis prevalence surveys in 1953, 1958 and 1963. The number of patients was 1, 308, 2, 090 and 1, 411 in the 1953, 1958 and 1963 surveys, respectively, and altogether 4, 308patients were subjected to the follow-up study. The ratio of male to female was 1.7: 1, and dividing by the extent of pulmonary lesions, far advanced cases occupied approximately 7%, moderately advanced cases 30% and minimal cases 55°0. The average age of patients was 37.1, 42.6 and 45.0 in 1953, 1958 and 1963, respectively.
The follow-up survey was made through the participation of all the prefectural and municipal governments and the health centers. All the patients were asked to come to the health center for bacteriologic and radiological examinations either by correspondence or by the home vist of public health nurses, and all the informations on patents including chest X-ray flm. therapeutic and registration status were collected to the Research Instiure of Tuberculosis. Japan Anti-Tuberculosis Association. For dead cases, the copy of death certificate was collected. For patients moved out from their original residence, the survey was made at the health center covering their new residence.View full abstractDownload PDF (1309K) -
1971 Volume 46 Issue 12 Pages 507-529
Published: 1971
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (7401K)
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