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Volume 48, Issue 8
Displaying 1-5 of 5 articles from this issue
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Toru MORI, Ryoji TAKAI1973 Volume 48 Issue 8 Pages 337-342
Published: August 15, 1973
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSA factorial experiment was performed in order to evaluate quantitatively the importance of technical errors in giving and reading tuberculin test. The analysis of variance showed that all of the involved sources of variation were statistically significant. These were; 1) among-subject (in this experiment, tuberculosis patient) difference, 2). between-injection difference in a subject (namely the variation in giving injection), 3) among-reader difference, and interactions. There was wide variation also in the judgement of whether a reaction had a so-called double erythema. Discussion was made on each of the errors. Considering that the tuberculin testing cannot be free from these errors, it was keenly felt necessary to standardize technique in the performance of the test through training of the personnels, and to take greatest care in interpreting the test-results.View full abstractDownload PDF (823K) -
Joint Study Unit of National SanatoriaYasumasa HIRO1973 Volume 48 Issue 8 Pages 343-349
Published: August 15, 1973
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSAs part of a joint study on cases of pulmonary tuberculosis combined with diabetes mellitus conducted at national sanatoria, bacteriological research was carried out. The data obtained from 820 cases of pulmonary tuberculosis with positive sputum and complicated with diabetes mellitus were collected and the results were summarized as follows;
1) Ratio of male to female was 3.7 (male) to 1 (female).
2) 75.7 percent of the patients were over 40 years of age.
3) Pulmonary tuberculosis was diagnosed prior to the discovery of diabetes mellitus in 584 cases (71.2%). In 116 cases (14.2%) pulmonary tuberculosis and diabetes mellitus were diagnosed simultaneously, and diabetes mellitus preceded in 120 cases (14.6%).
4) Patients were divided into two groups according to the degree of control of the diabetes: one group was well controlled and the other was not.
Bacillary conversion rate was compared between the two groups: the negative conversion rate was 83% in the well controlled group and 28.9% in the other group.
5) The negative conversion rates among the well controlled group were 58.1% for patients treated with SM, 58.6% with PAS, 60.4% with INH, 58.8% with KM, 70.8% with CS, 77.0% with EB, 80.0% with VM and CPM.
6) The negative conversion rate among the originally treated cases was 86.4% in the group of good diabetes control and 43.5% in the other.
7) Among the patients whose diseases were discovered simultaneously, the negative conversion rate was 87.3% in the well controlled group and was 76.7% in cases with diabetes mellitus preceded pulmonary tuberculosis.
8) Drug resistant bacilli. emerged after six months' treatment in 14.1% of the cases in which diabetes mellitus preceded and in 8.8% of the cases in which both diseases were diagnosed at the same time.
9) The clinical effect of ethambutol was considerably good for pulmonary tuberculosis when the diabetes mellitus was well controlled. The negative conversion rate was 59.4% in all cases. Unfaborable side effects were seen in 1.8% of the cases and it was not higher than that of non-diabetic pulmonary tuberculous patients.
Good control of diabetes mellitus is essential for the treatment of pulmonary tuberculosis. When adequate treatment is given to pulmonary tuberculosis patients who are combined with diabetes mellitus, the clinical effects would be similar to those for non-diabetic pulmonary tuberculosis patients, but higher emergence of drug resistance against anti-tuberculous drugs might be seen in cases with poorly controlled diabetes mellitus.View full abstractDownload PDF (993K) -
Teruo AOYAGI, Nobuo MAEKAWA, Toshimitsu FUKUHARA, Masahiko YAMAMOTO, T ...1973 Volume 48 Issue 8 Pages 351-356
Published: August 15, 1973
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThe therapeutic effects of Rifampicin (RFP) for tuberculous lymphadenitis were observed.
The patients subjected to this study were 29 cases who were diagnosed as tuberculous lymphadenitis at seven hospitals and the background factors of these cases were as follows; as to sex distribution, female was 69% and male 31%; nearly half were in the age group 21 to 30, previously treated cases were 44.9%, all positive for tuberculin skin test, chest X-ray was normal in 37.9% and abnormal findings requiring treatment in 44.9%, and tubercle bacilli were positive on culture from sputum in 6 and from menses blood in 1. Six cases were examined for tubercle bacilli in affected nodes and three cases showed positive culture. Out of five cases whose lymphnodes was biopsied, 4 were confirmed to be tuberculous lymphadenitis. The location of affected lymphnodes was as follows; 26 in neck, 5 in axilla, 2 in supraclavicular fossa and 4 in hilum or mediastinum, the size of those nodes varied from 60mm to 9mm and the mode was from 10 to 19mm, and ten nodes had tenderness and three node reddness.
RFP was administered every day in a dose of 450 mg and combined with INH-EB in 15 cases, NH in 7 cases, INH-VM in 2 cases, INH-PAS, INH-CS, KM-EB, INH-SM-EEB in each 1 case.
When the number of the affected nodes were over two, only two lymph nodes with large size or the node showing most acute condition were observed. Observation was possible for over 6 months in 15 cases, for 5 months in 1, 4 months in 1, 3 months in 4, 2 months in 4, 1 month in 3 and one case dropped out at two weeks and the follow-up was impossible.
Thirty seven affected lymph nodes could be observed over one month. Out of twenty nine lymph nodes with initial swelling type thirteen nodes showed marked regression within six months and sixteen disappeared within four months. Out of six lymph nodes with sclerotic type, four regressed markedly within three months and one unchanged at six months. One node with abscess was unchanged at one month, one with ulcer and fistula regressed markedly within three months. Accordingly' 94.6% of 37 affected nodes were improved and only 5.4% were unchanged. Three lymph nodes were completely extirpated under the coverage of the regimens including RFP, and no complications were observed.
It is concluded that the therapeutic effects of the regimens including RFP for tuberculous lymphadinitis are evaluated as excellent, as 44.9% of the cases were previously treated and 95% showed good response.View full abstractDownload PDF (788K) -
Kenji SAWAMURA, Masahiko SHIMOMURA1973 Volume 48 Issue 8 Pages 357-363
Published: August 15, 1973
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSSeventeen patients consisting of 6 caries of the dorsal vertebra, 8 caries of the lumbar vertebra, 1 sacroiliac tuberculosis, 1 knee-joint tuberculosis and 1 tarsal tuberculosis, received 450mg RFP every day for a period of six months to one year.
Clinical effects: The clinical effects were evaluated comprehensively by checking subjective symptoms, roentgenograms, fistulae, bacilli in pus and clinical findings. As aresult, they were evaluated as “excellent” in 3 patients, “good” in 8 and “unclear” in 4. And the remaining 2 patients showed “no improvement”.
Side effects: Allergic symptoms such as leukocytopenia, urticaria-like eruptions, etc. appeared in 3 patients, gastrointestinal symptoms with nausea in 1 patient and hepatic dysfunctions in 1 patient. Therapy was discontinued in three patients including one who developed leukocytopenia, one who developed aggravated dizziness/leukocytopenia and one who developed urticaria-like eruptions.
In conclusion, RFP is a drug which can be indicated for the treatment of bone and joint tuberculosis as well.View full abstractDownload PDF (853K) -
1973 Volume 48 Issue 8 Pages 365-385
Published: August 15, 1973
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (3558K)
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