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Volume 45, Issue 2
Displaying 1-3 of 3 articles from this issue
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Imasato DONOMAE, Shinnosuke FUJITA, Jiro GOMI, Naoyoshi HAYASHI, Susum ...1970 Volume 45 Issue 2 Pages 55-60
Published: February 15, 1970
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThe study deals with clinical effects of ethambutol (EB)-streptomycin (SM)-isoniazid (INH)versus paraaminosalicylic acid (PAS)-SM-INH in original treatment of pulmonary tuberculosis.
The cases with positive tubercle bacilli were allocated at random for two reg i m ens; EBSMINH group including 50 cases and PAS-SM-INH group including 46 cases after exclusion of those which had been proven as primary resistant cases or discontinued treatment by side effect.
EB was administered 1 gm daily in one dose for 60 days and 0.75gm daily for the following period until 6 months, SM was injected 1 gm twice weekly, and INH was given 0.4 gm daily in two divided doses while PAS was administered 10gm daily dividing after each meal.
The background factors of cases in each group were almost similar.
The clinical effects of the regimens were compared according to the rate of improvements of chest radiograms and bacilli conversion rate in sputa. No statistically significant difference was detected between both regimens: that is, the rate of improvements of basic lesions were 66% in EB group and 70% in PAS group after 3 months, 86% and 88%, respectively, after 6 months; the rate of improvement of cavities with nonsclerotic walls were 90% in EB group and 86% in PAS group after 6 months: and tubercle bacilli in sputa converted to negative in 78% after 3 months and 94% after 6 months by EB-SM-INH, and in 83% and 88%, respectively, by PAS-SM-INH.
No side effect was observed in EB group, while 7 cases in PAS group had adverse reactions including 4 cases of gastroenteric disturbances and one case of allergic reaction due to PAS and two cases due to SM including each one case of tinnitus and hypoaesthesia of face.
The authors concluded that EB will be given as a substitute of PAS for the original treatment cases of pulmonary tuberculosis treated by SM-INH-PAS if any adverse reactions by PAS have been observed.View full abstractDownload PDF (614K) -
Hisao NAKANO1970 Volume 45 Issue 2 Pages 61-64
Published: February 15, 1970
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSHirano and Sushida found that atypical mycobacteria isolated in Japan and in the United States caused tuberculous changes not only at the site of inoculation, but also produced evidence of visceral tuberculosis in some cases when they were inoculated into the testicles of rabbits. The present study was designed to elucidate the pathogenicity of three groups of atypical mycobacteria, i. e. non-photochromogens, photochromogens, and scotochromogens, and the following results were obtained
Rabbits inoculated intratesticularly with a suspension of atypical mycobacteria showed tuberculous lesions at the site of the injection and in some cases tuberculous nodules were also observed in the lungs, spleen, liver, and kidneys. These lesions produced by I, II and III groups were almost similar and indistinguishable. Atypical mycobacteria heated at 100°C for 30minutes did not cause pathological changes after intratesticular inoculation, but the H37Rv strain killed by heat caused necrosis at the site of inoculation.View full abstractDownload PDF (4675K) -
Kokichi OKAMOTO, Sadatomo WATANABE, Kiyo TERUNUMA1970 Volume 45 Issue 2 Pages 65-72
Published: February 15, 1970
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSIn the previous study, one of the authors proposed a method to evaluate the serum antimycobacterial activity. By this method, however, the activity of CS and EB in sera from patients who had received a usual single dose of CS 250mg or EB 500 mg was not detected. Recently, clinical results of treatment with these drugs including the sputum culture negative conversion rate and the emergence of resistant organism have been obtained. The purpose of this study is to determine the criteria of clinical resistance to these drugs based on the relation between the serum antimycobacterial activity and the emergence of resistant organisms.View full abstractDownload PDF (6385K)
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