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Volume 49, Issue 8
Displaying 1-4 of 4 articles from this issue
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Masahiko KATO1974 Volume 49 Issue 8 Pages 229-238
Published: 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSTuberculosis in man and laboratory animals is characterized by progressive wasting symptoms. As a causative agent of such intoxication signs in tuberculou8 infection, H. Bloch has reported the existence of a peculiar lipid toxin possessing a characteristic delayed toxicity for mice in petroleum-ether-extract of virulent Mycobacterium tuberculosis. Since the solvent extracted-bacilli have lost the property to grow in culture medium in forming “cords”, this toxic lipid was named as “cord factor”. The chemical structure of cord factor was subsequently identified as a 6, 6'-dimycoloyl-α, α'-D-trehalose.View full abstractDownload PDF (3639K) -
Tsutomu WACHI, Bunji INOUYE1974 Volume 49 Issue 8 Pages 239-246
Published: 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSRifampicin possesses a high antibacterial activity both in vitro and in vivo against Mycobacterium tuberculosis and is used routinely as an effective antituberculous drug. In accordance with an increase in its application to pulmonary tuberculosis, however, various side effects caused by the administration of rifampicin have been reported. It has therefore become necessary to investigate the mechanism by which side effects occur. This paper describes some experiments planned to clarify the biological effects of rifampicin and its derivatives on liver mitochondria in connection with the relationship between liver functio n. disorders after the administration of rifampicin and the mitochondrial functions.View full abstractDownload PDF (1673K) -
—Report of the 16th Series of Controlled Trial of Chemotherapy—Cooperative Study Unit on Chemotherapy1974 Volume 49 Issue 8 Pages 247-252
Published: 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSPreviously untreated pulmonary tuberculosis in-patients, 240 in number, were allocated at random to the following two regimens:View full abstractDownload PDF (1105K) -
Kazuhiko KAMEDA1974 Volume 49 Issue 8 Pages 253-258
Published: 1974
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSAggravation of pulmonary tuberculosis is usually defined simply as positive conversion of tubercle bacilli in sputum or reactivation of radiological findings. Among them, however, some episodes are not significant during the clinical course of tuberculosis.
In order to analyse these points, 85 patients who were diag n osed as having an aggravation of tuberculosis according to the above mentioned criteria and readmitted to our hospital during the period from 1967 to 1972 were studied.
Based on the results of follow up of cases with different kinds of so called bacteriological relapse solely, radiological relapse solely and both bacteriological and radiological relapses, following conclusions were obtained.
The following three findings which were found among cases showing negative sputum both on smear and culture for more than 3 months are considered to have no significant meaning in the clinical course of pulmonary tuberculosis (minor aggravation):
1) Smear positive culture negative findings observed less than three co n secutive times without radiological aggravation.
2) Small amount of positive bacilli on culture (less than 20 colonies) observed only once without radiological aggravation.
3) Worsened radiological findings without bacilli discahrge and improved markedly within two months.
Cavitation observed during the treatment of tuberculoma showing gradual decrease in its size on X-ray film should not be regarded as aggravation.View full abstractDownload PDF (1252K)
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