Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 24, Issue 2
Displaying 1-15 of 15 articles from this issue
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Contents
  • A Cytological Study of the Exfoliative Cells from Pancreatic Duct
    -Special Reference to the Differentiation of Atypical Cells of Chronic Pancreatitis and Pancreatic Cancer Cells-
    HIROFUMI GONDA
    1978 Volume 24 Issue 2 Pages 144-159
    Published: June 10, 1978
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.24.144
    JOURNAL FREE ACCESS
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    Considerable difficulty is sometimes encountered in cytodiagnostic differentiation of atypical cells in chronic pancreatitis from pancreatic cancer cells. To obviate such a difficulty, an endoscopic intraductal brushing method has been devised to collect sufficient exfoiated epithelial cells from the pancreatic duct. A cytomorphologic study of exfoliated epithelial cells has been carried out in normal, mild chronic pancreatitis, advanced chronic pancreatitis and pancratic carcinoma cases. The incidence of atypical cells was related to the grade of panereatitis. In normal case and midi chronic pancreatitis, the indidence of atypical cells was decreased and in advanced chronic pancreatitis was it increased. The findings of atypical cells in these cases were similar to the malignant cells whicr must be differenciated strictly from atypical cells. The cells measuring more than 20μ in cellular diameter and over 18μ in nuclear diameter were not demonstrated in any of the advanced cases of chronic pancreatitis. Another point of diagnostic importance consists of marked anisokaryosis, nuclear atypism, abnormal overlaping, and anisochromatism.
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  • Echocardiographic Study on Coronary Heart Disease
    Correlations of Cineangiography, Electrocardiography and Clinical Findings
    FUSAKO KUDO
    1978 Volume 24 Issue 2 Pages 160-182
    Published: June 10, 1978
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.24.160
    JOURNAL FREE ACCESS
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    Eighty patients with coronary heart disease were studied with echocardiography, which findings were compared with electrocardiograms, coronary angiograms, data by catheterisation and clinical features. 1) An asynergic wall detected by echocardiography was mostly a suggestion of a stenosis more than 75% of the lumen of a coronary artery supplying the wall. On the contrary, not all the cases which showed a similarly severe stenosis of the artery on coronary angiography appeared an asynergy of the wall : the echo motion of the septal wall was asynergic only in 35% of those revealing a severe stenosis of the left descending coronary artery, while the same pattern was found on the anterior wall of the left ventricle in 92% of the cases. When the right or left circumflex coronary artery suffering from a severe stenotic change, 33% of these showed an asynergic echo motion on the posterior wall of the left ventricle. 2) In 80% of the anterior and posterior wall lesions of the left ventricle the localization by echocardiography well coincided with that of the electrocardiography. When the septal wall was affected the coincidence of both examinations became 43%. 3) The infarcted wall is not only asynergic, but it has to be left out of thickning of the systole, too. A certain exaggeragtion of the septal wall motion seen on the cases of the posterior infarction was regarded as a compensation for this. But the compensatory motion did occur no where in the cases of the anteroseptal infarction. 4) The mitral b-b' step formation and mean velocity of circumferential fiber shortening (mVcF) were important indices for evaluating the function of the left ventricle. 5) Whether or not left heart failure is associated with the anteroseptal infarction made significant differences on the diastolic dimension of the left ventricle, on the mVcF, on the ejection fraction, on the number of asynergic wall as well as on the mitral b-b' step formation. 6) Echocardiography was also evaluated in detectability of same complications associated with a myocardial infarction. In conclusion, echocardiography is a useful non-invasive examination to find out the infarction zone, to evaluate the left ventricular function and to follow up a patient after an attack of an infarction.
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  • Long-Lasting Effect of Early Postnatal Treatment with Estrogen on the Hypothalamo-Hypophysio-Ovarian Axis in Female Rats
    CHING-YUAN CHEN
    1978 Volume 24 Issue 2 Pages 183-193
    Published: June 10, 1978
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.24.183
    JOURNAL FREE ACCESS
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    Successive subcutaneous injections with various doses of diethylstilbestrol (DES) was given to the female Wistar rats for different durations from the day of birth. After maturation, the two halves of each group were sacrificed at 3 and 6 months of age, respectively. The effects of early postnatal treatment with DES on the hypothalamo-hypophysio-ovarian axis were investigated. Neonatal DES treatment resulted in anovulatory conditions in all groups of the treated females. The ovarian weights of DES-treated rats were significantly smaller than those of the control females. The rats which were injected with DES 1 or 7 μg neonatally for 10 days had “sterile ovaries” containing many large vesicular follicles but not no corpora lutea. In rats treated with DES for the first 20 or 30 days of life, the ovaries were markedly atrophic and contained only small follicles with poorly developed atria. These histological findings were closely correlated with levels of the pituitary and plasma gonadotropins (FSH, LH) measured by radioimmunoassay (RIA). In either case of animals sacrificed at the age of 3 or 6 months, it was evident there was a disturbance in the secretory function of pituitary gonadotropins. Especially, in the groups receiving longterm treatment with DES, the synthesis and secretion of pituitary gonadotropins seemed to be permanently inhibited after the cessation of DES injections. On the electron microscopic examinations, small gonadotropes which were not common in the normal anterior pituitary were frequently observed in those of DES-treated animals. These small sized gonadotropes were quite similar to the atrophic gonadotropes which appeared in the pituitary transplants beneath the renal capsule. These suggest that hypophysiotrophic influence from the hypothalamus may be less active on these pituitary gonadotropes of DES-treated rats. In addition, effects of the injection period on the development of anovulatory sterility were examined. When the same total dose of DES was given, it was found that the regulatory function of gonadotropin secretion was more seriously affected in the groups receiving long-term treatment than in the groups receiving short-term treatment, based on the results of histological and electron microscopic examinations and RIA. From these points of views, a long-lasting effect of sex steroids on sexual centers in the course of the early postnatal development seems to be highly dependent on the dose and length of the injection poriod of DES.
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  • Interruption of Pseudopregnancy by Ergot Alkaloids in Female Rats
    Effects of Catecholamine Receptor Blockers
    CHING-YUAN CHEN
    1978 Volume 24 Issue 2 Pages 194-198
    Published: June 10, 1978
    Released on J-STAGE: November 21, 2014
    DOIhttps://doi.org/10.14789/pjmj.24.194
    JOURNAL FREE ACCESS
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    Female Wistar rats were injected subcutaneously with 1mg/kg reserpine on the day of diestrus-I to induce pseudopregnancy. Three days later, the reserpine-treated rats were adiministered additionally with nialamide (250mg/kg, monoamine oxidase inhibitor), L-DOPA (250mg/kg) or ergot alkaloids (1mg/kg, ex., ergocornine & ergocryptine). At the same time, one of the uterine horns was traumatized to examine deciduoma formation. Treatment with nialamide or L-DOPA was not effective to interrupt reserpine-induced pseudopregnancy. Deciduoma formation occurred in all rats receiving nialamide or L-DOPA 3 days after reserpinization. However, no deciduoma response was obtained in the rats treated with ergocornine or ergocryptine on the same day. Inhibitory effect of ergocornine on deciduoma formation failed to reverse by simultaneous injection of phentolamine (α-receptor blocker) or propranolol (β-receptor blocker) with ergocornine. On the contrary, when pimozide and ergocornine were given together to the reserpine-treated rats, the effect of ergocornine was found to be inhibited. All rats treated with pimozide concurrently with ergocornine or ergocryptine had deciduoma in their traumatized uterine horn. Since pimozide was regarded as a blocker of dopamine receptor, the interruption of pseudopregnancy induced by ergocornine or ergocryptine was considered to be correlated with the dopaminergic mechanism.
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