Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 36, Issue 2
Displaying 1-15 of 15 articles from this issue
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Contents
  • Effect of FK-506, Ciclosporin on the survival of corneal grafts in rabbits
    CHIHIRO KOBAYASHI
    1990 Volume 36 Issue 2 Pages 189-196
    Published: July 20, 1990
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.189
    JOURNAL FREE ACCESS
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    In an assessment of the immunosuppressive efficacy of FK-506 following corneal allograft transplant surgery preceded subconjunctival injection of either FK-506 or Ciclosporin (CYA) eye drops and topical administration of both FK-506 and CYA. For FK-506, survival rates were as follows : exchange keratoplasties (0.1mg/Kg twice a week), 100% at 100 days ; re-keratoplasties (0.1mg/Kg twice a week), 88% at 100 days ; and exchange keratoplasties (0.01mg/Kg once a week), 100% at 200 days. For CYA, survival rate exchange keratoplasties (0.025% 4 times a day) was 100% at 100 days, and that of re-keratoplasties (0.025% 4 times a day) was 66% at 40 days. Even topical administration of FK-506 and CYA together suppressed allograft rejection of experimental keratoplasties. We found that topical administration of FK-506 and CYA may be an effective immunosuppressant in clinical keratoplasties.
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  • Distribution of SH base and S-S bonds in normal and healing cornea
    YASUHIKO KOBAYASHI
    1990 Volume 36 Issue 2 Pages 198-206
    Published: July 20, 1990
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.198
    JOURNAL FREE ACCESS
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    This study was conducted in order to elucidate the localization of SH bases as well as S-S bonds in normal and healing cornea of albino rabbits weighing about 2.0kg. Under normal conditions, fluorescence of SH bases is detected in abundance in the cytoplasm of epithelial, stromal and endothelial cells. The fluorescence of S-S bonds is detected in the epithelial basement membrane, Descemet's membrane, and the extracellular matrix of the corneal stroma. In healing cornea, abundant, intense fluorescence of SH bases was observed in the cytoplasm of sliding, proliferating epithelium, and detection by staining of stromal cells adjacent to the healing site gradually increased. However, the fluorescenc of S-S bonds was not noted. These results strongly suggest that wound-healing in the cornea may be dependent on the metabolism of SH basecontaining substances.
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  • Trabeculectomy : A follow-up study
    CHIAKI NEGISHI
    1990 Volume 36 Issue 2 Pages 207-215
    Published: July 20, 1990
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.207
    JOURNAL FREE ACCESS
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    Trabeculectomy, trabeculectomy with cyclodialysis, and trabeculectomy with cataract extraction were performed on 103 eyes in 86 patients. Trabeculectomy was performed on 68 eyes in 56 patients, and intraocular pressure (IOP) was maintained at under 20mmHg in 70.5 % of trabeculectomies with or with out the use of additional eye drops and oral medication. Trabeculectomy with cyclodialysis was performed on 18 eyes in 14 patients and IOP was maintained at under 20mmHg in 77.8% of procedures with or without the use of additional eye drops and oral medication. Trabeculectomy with cataract extraction, including intraocular lens implantation, was performed on 17 eyes in 16 patients, the IOP was maintained at under 20mmHg in 82.4 % of procedures with or without the use of additional eye drops and oral medication. For primary open angle glaucoma the success rate in patients less than 40 was significantly lower than in those over 40. In cases of re -operation on poorly controlled eyes, trabeculectomy was less effective than primary operation. Progressive increase in visual field defects was observed in 13 eyes in which IOP was well -controlled.
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  • Corneal mosaic pattern
    ICHIRO EMOTO
    1990 Volume 36 Issue 2 Pages 216-223
    Published: July 20, 1990
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.216
    JOURNAL FREE ACCESS
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    This study examined the differences in and origins of corneal mosaic patterns, which may be clinically observed as follows : (1) so-called anterior corneal mosaic induced by rubbing the cornea through the eyelids following instillation with fluorescein sodium ; (2) a pattern seen against a red reflex ; (3) a pattern during applanation tonometry ; and (4) a pattern in anterior crocodile shagreen and posterior crocodile shagreen. Photographs revealed an accurate correspondence in the arrangement of the first three. Anterior corneal mosaic was observed in all normal cornea of over 500 Japanese people aged 3 to 90 and remained unchanged after one year. Bovine cornea showed anterior corneal mosaic and a polygonal ridge pattern by fixation following massage of the cornea. Histological study revealed only a difference in stromal thickness under the ridge. The pattern of anterior crocodile shagreen was matched to the fluorescein pattern. These observations suggest that the underlying basis of the anterior corneal mosaic is the particular arrangement of collagen lamellae in the anterior corneal stroma just basal to Bowman's membrane. In posterior crocodile shagreen, slit-lamp examination showed oblique or V-shaped clear lines with apices pointing to Descement's membrane and rays directed toward the anterior third of the stroma. Even in normal eyes over the age of 50, such lines were observed in high incidence in the limbal area of the cornea. Moreover, histological study of normal cornea revealed waving of collagen lamellae from the periphery to the center, which seems to correspond to the clear line. It is suggested that the oblique waving line of collagen lamellae forms the posterior reticular structure in normal cornea.
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  • Morphological and functional analysis by echocardiography of hearts with asymmetrical septal hypertrophy
    MUTSUO UCHIDA
    1990 Volume 36 Issue 2 Pages 224-235
    Published: July 20, 1990
    Released on J-STAGE: November 20, 2014
    DOIhttps://doi.org/10.14789/pjmj.36.224
    JOURNAL FREE ACCESS
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    This study attempted to define morphological and functional abnormalities in hearts with asymmetrical septal hypertrophy (ASH) according to the presence or absence of hypertension by using two-dimensional and doppler echocardiography. Subjects with ASH hearts were separated into 2 groups, those with hypertension (hypertension group) and those without hypertension (hypertrophic cardiomypathy (HCM) group). In morphological analysis by two-dimensional echocardiography, septal hypertrophy by the long-axis view was classified as Mid-portion (M-type), Diffuse (D-type), or Basal (B-type) hypertrophy, and by the short-axis view as Diffuse (I -type), Anterolateral (II-type), Anteroseptal (III-type), or Anterior-septal (IV -type) hypertrophy. Basal hypertrophy occurred significantly more often in the hypertension group. Anterior-septal hypertrophy was observed in only 7 HCM hearts. Functional evaluation by pulsed doppler echocardiography measured the following parameters : as indices of systolic function, stroke volume (SV), cardiac output (CO), mean Vcf, and fractional shortening (%FS), and as indices of diastolic function, rapid filling peak velocity (R), presystolic peak velocity (A), A/R, acceleration half time (AHF), and deceleration half time (DHT). From the results, it seems that the systolic function of the HCM group was equal to or slightly higher than that of the normal group. Diastolic function showed no appreciable reduction even in hearts with marked ASH unless hypertrophy was diffuse or associated with hypertension.
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