Juntendo Medical Journal
Online ISSN : 2188-2134
Print ISSN : 0022-6769
ISSN-L : 0022-6769
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Volume 38, Issue 1
Displaying 1-20 of 20 articles from this issue
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Contents
  • Intraventricular infusion of nerve growth factor (NGF)
    suppresses body weight gain of adult rats
    KOU ETO
    1992 Volume 38 Issue 1 Pages 56-61
    Published: June 01, 1992
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.38.56
    JOURNAL FREE ACCESS
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    Our previous study revealed that intraventricular infusion of NGF significantly inhibited body weight gain in the rats with fetal basal forebrain tissue grafted into the lateral ventricle, compared to the controls. In the present study, similar results were obtained in the rats without fetal basal forebrain grafts following intraventricular infusion of NGF for two weeks. These findings indicated that NGF exerted an inhibitory influence on body weight gain in adult rats. The changes in body weight gain in the rats administered intraventricularly 20μg/ml of NGF did not differ significantly from those administered 100μg/ml of NGF. However, there was no significant difference in the daily food intake between any of the NGF-treated groups and the control group. This suggests that there is no correlation between the change in daily food intake and the reduction in body weight gain. Since administration of exogenous NGF into the brain is being considered as a potential therapy for senile dementia of Alzheimer type, more research is necessary on the mechanism and functional significance of the response observed in this study before initiation of NGF infusion therapy.
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  • The relation between the nutritional status of the host and the effect of passive immunotherapy with LAK cells in mice
    TOMOYUKI SHIKURA
    1992 Volume 38 Issue 1 Pages 62-70
    Published: June 01, 1992
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.38.62
    JOURNAL FREE ACCESS
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    A malnourished and immunodepressed condition is one significant feature of cancer cachexia. Active immunotherapy has been proven insufficient under such a circumstance. We examined whether adoptive immunotherapy with lymphokine activated killer cells (LAK cells) would be efficient in the case of cachexia using two nutritional model systems. In one group, C57BL/6 mice were given an ordinary diet as a normal nutrition model and in another group was fed with low protein and low fat diet as a cachexic model. Both groups of mice were inoculated subcutaneously with BL 6 melanoma cells to determine whether the tumor growth was dependent on the nutritional status. The findings showed that tumor growth was not dependent on host nutritional status. In another experiment, splenocytes from normal mice were cultured with IL-2 for 4 days, and LAK cells were harvested. Pulmonary metastases were established by i. v inoculation of melanoma cells. Using this pulmonary metastatic model, we evaluated the effect of LAK adoptive immunotherapy on the inhibition of pulmonary metastases. LAK cells were injected intravenously with melanoma cells into the two groups of mice. Then the number of pulmonary metastatic nodules in the two groups was counted and compared with the number in the groups not treated with LAK cells. LAK adoptive immunotherapy could inhibit the pulmonary metastases and prolong the survival period in both control and cachexic models. These findings indicated that LAK adoptive immunotherapy would be efficient in the case of cachexia.
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  • Psychogenic reaction of the mildly retarded and borderline intelligence patients
    TADASHI ITOH
    1992 Volume 38 Issue 1 Pages 71-83
    Published: June 01, 1992
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.38.71
    JOURNAL FREE ACCESS
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    The sex, education, clinical course, and results of the Wechsler Adult Intelligence Scale (WAIS) of 46 mildly retarded and/or borderline intelligence patients, were investigated. The subjects were 34 inpatients and 12 outpatients treated from April 1, 1984 to December 31, 1990 at Juntendo University Hospital and Juntendo Koshigaya Hospital both affiliated to Juntendo University. There were more female patients than male patients. The average age of first onset was 21 years old both for males and females. There was no relationship between age of first onset and intelligence. Among the WAIS low rank examinations, significantly low marks were obtained in vocabulary than the other low rank examinations except for arithmetic. With respect to the relationship between education and intelligence, high school graduates or more highly educated had significantly higher intelligence than junior high school graduates. The common mental causes were human relations, poor marks in school work, physical diseases, and accidents. The common figures of conditions were mental anxiety condition, hysteria, and delusion in this order. Intelligence of subjects presenting with a mental anxiety condition was significantly higher than that of subjects presenting with hysteria. There was no significant relationship between the prognosis and intelligence. Social environmental factors were thought to establish the psychogenic reactions. The stronger the limitation became, more immature became the condition. There were frequent transitions among individual conditions with no consistent depression. The prognosis was not affected by intelligence. It was rather affected by the attitude of family members and adjustment to social environment. Further longterm follow-up investigations were considered to be necessary on these points.
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  • Influence of intrathecally used contrast dye (Iotrol) on cerebral cortical activities.
    -Quantitative EEG study-
    YUKO URAKAMI, HIROTOSHI SUMIE, SHIGEKO OKADA, YUTAKA KURU
    1992 Volume 38 Issue 1 Pages 84-94
    Published: June 01, 1992
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.38.84
    JOURNAL FREE ACCESS
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    The potential neurotoxicity of Iotrol used in cervical myelography was determined by examining three criteria; clinical symptoms, EEG recordings with frequency analysis (by quantitative EEG study), and CT scan of the brain of 25 patients. The CT observation informed how far the contrast dye diffused into the subarachnoid spaces. Clinical symptoms developed in two patients with EEG abnormalities; in one case, hallucination (visual) appeared, and other, headache. Two other patients showed EEG abnormalities without clinical symptoms. Such abnormalities diminished within a week. Quantitative EEG study showed increased delta activities, most frequently in the left O area (p<0.05-0.10), as well as decreased alpha activities mostly the left O area (p<0.05). We conclude that quantitative EEG study is very important in the evaluation of neurotoxicity of contrast dye to central nervous system, especially among patients who show penetration of the dye into brain parenchyma, and that EEG recordings obtained 3-4 hrs after injection can be used to predict adverse effects which may appear more than 24 hrs later.
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  • Fundamental pharmacokinetic study of intrahepatic arterial Adriamycin (ADR) and influence of plasma exchange in dogs.
    TSUTOMU KANNO
    1992 Volume 38 Issue 1 Pages 95-102
    Published: June 01, 1992
    Released on J-STAGE: November 18, 2014
    DOIhttps://doi.org/10.14789/pjmj.38.95
    JOURNAL FREE ACCESS
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    Peripheral blood levels of Adriamycin (ADR) after intrahepatic arterial administration were compared with those after intravenous administration in dogs. The effect of combined plasma exchange with intrahepatic arterial administration on the peripheral blood level of ADR was also studied pharmacokinetically. For this study 9 adult mongrel dogs were divided in to 3 groups for intravenous administration, intrahepatic arterial administration and intrahepatic administration with plasma exchange. The pharmacokinetics of AD R was evaluated by the trapezoidal rule. The mean area under the curve up to 30 min after administration (AUC5→30) was 3.66μg/ ml/ min in the intrahepatic administration group and 4.89μrg/ ml/ min in the intravenous administration group, showing a slightly lower level in the intrahepatic aretrial administration group. The mean area under the curve from 30min to 120 min after administration (AUC30→120) was 3.33μg/ ml/ min in the intrahepatic arterial administration group and 2.85μg/ ml/ min in the intravenous administration group, showing a higher level in the intrahepatic arterial administration group. The overall mean AUC (AUC5→120) was 6.98μg/ ml/ min in the intrahepatic arterial administration group, being similar to that of the other groups. These findings showed that a considerable amount of the ADR leaked systemically after passing through the liver by intrahepatic arterial administration. The AUC5→30 in the intrahepatic arterial administration with plasma exchange group was 3.66μg/ ml/ min, which was similar to the level in the intrahepatic arterial administration group. However, the AUC3 in the group, was as low as 3.33μrg/ ml/ min, which indicates that about 2.3μg/ml/ min (about 44% of UC5→120) of ADR was eliminated by plasma exchange.
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