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Volume 34, Issue 11
Displaying 51-71 of 71 articles from this issue
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MINORU UDHIDA, FUJIO TABUSA, MAKOTO KOMATSU, SEIJI MORITA, TOSHIMI KAN ...1986 Volume 34 Issue 11 Pages 4821-4824
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe metabolites of 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic acid (OPC-12759) (1), which has a potent antiulcer activity towards acetic acid-induced gastric ulcer, were synthesized to confirm their structures and to examine their antiulcer activity. The structures of the major metabolites (2-4) in the rat were identified by means of comparisons with the synthetic compounds. The antiulcer activity of the metabolites (2-4) was found to be lower than that of 1.View full abstractDownload PDF (461K) -
TAKUO KOSUGE, KUNIRO TSUJI, HITOSHI ISHIDA, TOMOHIKO YAMAGUCHI1986 Volume 34 Issue 11 Pages 4825-4828
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe anti-histaminic principle in green-lipped mussel (Perna canaliculus) was isolated by a combination of countercurrent distribution and column chromatographies on silica gel and Sephadex LH-20, and identified as lysolecithin.View full abstractDownload PDF (479K) -
YOSHIKAZU KONDO, KYOKO SUGIYAMA, SHIGEO NOZOE1986 Volume 34 Issue 11 Pages 4829-4832
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSTwo labdane-diterpenes, vitexilactone and previtexilactone, instead of the previously described rotundifuran and prerotundifuran, have been isolated from the fruits of Vitex rotundifolia L. fil. (Verbenaceae) together with p-hydroxybenzoic acid, vanillic acid and three flavones.View full abstractDownload PDF (477K) -
TOSHINOBU MORITA, JUN ZHOU, OSAMU TANAKA1986 Volume 34 Issue 11 Pages 4833-4835
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe ginseng dammarane saponin, ginsenoside-Rg1, and the oleanolic acid saponins, chiku-setsusaponin-IV and pseudo-ginsenoside-RT1, were isolated in yields of 0.02, 0.15 and 0.04%, respectively, from roots and small rhizomes of Panax pseudo-ginseng WALL. subsp. pseudo-ginseng HARA collected at Nielamu, Tibet. A saponin formulated as 3-O-α-L-arabinofuranosyl(1→4)-β-D-glucuronide of oleanolic acid was also isolated in a partially purified state. The chemotaxonomical significance of the results is disccussed.View full abstractDownload PDF (425K) -
ITSUO MORI, YOSHIKAZU FUJITA, KINUKO FUJITA, TAKESHI TANAKA, YOZO KOSH ...1986 Volume 34 Issue 11 Pages 4836-4839
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSColor reaction systems among throium(IV) {Th(IV)}, lanthanum(III) {La(III)} and xanthene derivative such as gallein (gall), in the coexistence of amphoteric and nonionic surfactants were studied, and spectrophotometric determinations of these metal ions (0-50μg of Th(IV) or La(III)/10ml) at 620nm by using gall-Th(IV)-La(III) ternary complex in the coexistence of sodium N-lauroylsarcosine (LS) as an amphoteric surfactant and Brij-35 as a nonionic surfactant were developed. The influences of foreign ions in this proposed method were greatly reduced (to 1/2-1/10) in comparison with the method in the presence of cationic surfactant alone.View full abstractDownload PDF (497K) -
IKUO WADA, NOBUYUKI KOGA, SHIN'ICHI YOSHIHARA, HIDETOSHI YOSHIMURA1986 Volume 34 Issue 11 Pages 4840-4843
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe binding of flavin-adenine dinucleotide (FAD) in DT-diaphorase was studies. Incubation with 4M guanidine-HCl at 0°C rapidly dissociated FAD from the enzyme, and incubation of the apo-enzyme with FAD at 37°C restored maximally about 50% (for menadione-reducing activity), or 330% (for ferricyanide-reducing activity) of the initial activity. The half-time required to reconstitute the apo-enzyme with FAD was 2min for menadione-reducing activity and the Km value of the apo-enzyme for FAD was 0.23μM. These results show that DT-diaphorase contains non-covalently bound FAD as a prosthetic group.View full abstractDownload PDF (445K) -
ATSUSHI HONDA, YOSHIAKI OHASHI, YO MORI1986 Volume 34 Issue 11 Pages 4844-4847
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSTo determine whether or not the high-molecular-weight (>2×106) hyaluronic acid in rabbit pericardial fluid contributes to the changes in the viscosity of the pericardial fluid, we compared the viscosity of rabbit pericardial fluid with that of various glycosaminoglycan solutions by using a cone and plate viscometer at 37°C. Rabbit pericardial fluid showed non-Newtonian flow behavior and had an apparent viscosity of about 1.03-1.04cP at a shear rate of 750s-1 as 37°C. On the basis of the data on the viscosity of pericardial fluid and of high-molecular-weight hyaluronic acid solutions, the high-molecular-weight hyaluronic acid (about 0.01% (w/v)) could contribute to the increase in the viscosity and the rheological characteristics of the pericardial fluid. These results suggest that the high-molecular-weight hyaluronic acid in the pericardial fluid could provide the heart tissue with resiliency and compliance when the tissue is subjected to stretching or compressive forces.View full abstractDownload PDF (428K) -
SADAKI FUJIMOTO, YASUKO ADACHI, SUSUMU ISHIMITSU, AKIRA OHARA1986 Volume 34 Issue 11 Pages 4848-4851
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSWhen deoxyribonucleic acid (DNA) was treated with ascorbic acid (AsA) in the presence of Cu2+ under aerobic conditions, significant releases of cytosine, thymine, guanine and adenine from the DNA molecule occurred. Addition of catalase or chemical scavengers of hydroxyl radical to the reaction mixture prevented the release of the bases. Monoesterified phosphate groups were found in the reaction mixture, indicating that the cleavage of DNA had occurred. The total amount of the bases released was almost equivalent to the amount of monoesterified phosphate groups formed by the reaction of DNA with AsA and Cu2+. These results indicate that the release of the bases from DNA molecule was easily caused by activated oxygen, possibly by hydroxyl radicals and/or hydrogen peroxide, formed by the autooxidation of AsA in the presence of Cu2+.View full abstractDownload PDF (505K) -
TAKAAKI AOYAGI, TAKAO WADA, FUKIKO KOJIMA, MACHIKO NAGAI, SHIGEKO HARA ...1986 Volume 34 Issue 11 Pages 4852-4854
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSIn order to confirm the pathophysiological isgnificance of the dissociation between the plasma levels of aminopeptidases A and B in spontaneously hypertensive rats, we tested the effects of several enzyme inhibitors including inhibitors of aminopeptidase B on the course of hypertension in these rats. In addition to an ihibitor of angiotensin-converting enzyme, inhibitors of aminopeptidase B (arphamenine B and bestatin) significantly suppressed the development of hypertension in these animals. This finding may represent an important clue to the pathogenesis of essential hypertension.View full abstractDownload PDF (397K) -
DAIICHI WATANABE, TAKASHI FUKUTANI, HIROSHI IKAWA, TETSUAKI YAMAURA, N ...1986 Volume 34 Issue 11 Pages 4855-4858
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSTwo crystal forms of the new dihydropyridine derivative, methyl (E)-3-phenyl-2-propen-1-yl 1, 4-dihydro-2, 6-dimethyl-4-(3-nitrophenyl)pyridine-3, 5-dicarboxylate (FRC-8411), were obtained by recrystallization from methanol. These crystal forms were identified by using powder X-ray diffractometry, infrared spectroscopy, differential scanning calorimetry (DSC) and thermogravimetry. By means of DSC, the melting points of forms I and II were found to be 140 and 121°C, respectively.Forms I and II, having a similar particle size distribution, were administered orally or intravenously to spontaneously hypertensive rats. In the case of oral administration, the hypotensive action of form I was milder than that of form II and tachycardia was not observed after administration of form I.View full abstractDownload PDF (463K) -
MASA-AKI MORI, MASAMI INOUE, TETSUJI NUNOZAWA, TATSURO MIYAHARA, HIROS ...1986 Volume 34 Issue 11 Pages 4859-4861
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS4-Acetylamino-2-hydroxylaminotoluene (4AA2HAT) and 2-hydroxylamino-6-nitrotoluene (2HA6NT) were prepared from 4-acetylamino-2-nitrotoluene (4AA2NT) and 2, 6-dinitrotoluene (2, 6-DNT), respectively, by reduction with zinc dust and NH4Cl. 2, 6-Dinitrobenzylalcohol (2, 6-DNB) and 2, 6-dinitrobenzoic acid (2, 6-DNBA) were prepared from 2, 6-dinitrobenzaldehyde (2, 6-DNBA1) by reduction with NaBH4 and by oxidation with KMnO4, respectively. 2-Acetylamino-4-aminobenzoic acid (2AA4ABA) was prepared from 4-nitroanthranilic acid (4NAA) by acetylation followed by reduction with NaBH4 and Pd-C. 2, 4-Diacetylaminobenzoic acid (2, 4-DAABA) was prepared from 4NAA by reduction with NaBH4 and Pd-C followed by acetylation. 4-Acetylamino-2-aminobenzoic acid (4AA2ABA) was prepared from 4NAA by reduction and acetylation followed by chelation with Cu(AcO)2.View full abstractDownload PDF (471K) -
MOTOHARU IWATSURU, KIYOSHI SHIMIZU1986 Volume 34 Issue 11 Pages 4862-4865
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSIn this paper, we discuss the reason why plots of the reciprocal of ([sodium dodecyl sulfate]-cmc) against the reciprocal of the shift-length of the absorption maxima of solubilized alkylparabens show linearity, and what information can be derived from the straight line. Extrapolation of the double-reciprocal plot was utilized to obtain the maximum value of the shift-length, which can not be measured directly. The average of the distribution parameter values can be obtained from the slope of the plot.View full abstractDownload PDF (431K) -
JYOJI KURITA, HIROKAZU KOJIMA, TAKASHI TSUCHIYA1986 Volume 34 Issue 11 Pages 4866-4870
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe thermal cycloaddition reaction of 1-ethoxycarbonyl-1H-1, 3-diazepines (4a, b) with 2, 5-dimethyl-3, 4-diphenylcyclopentadienone (5) gave three kinds of 1 : 1 cycloadducts, exo [6+4]π (6), syn-endo [4+2]π (7), and anti-endo [4+2]π (8) cycloadducts, the structures of which were elucidated by spectral analyses and the following photochemical study. Irradiation of the [4+2]π cycloadducts 7 and 8 resulted in an intramolecular [2+2]π cycloaddition to afford the cage compounds 12 and 13, respectively, while the [6+4]π cycloadducts (6), upon irradiation, underwent a retro-reaction to give the bicyclic compounds (11), presumably via the parent 1, 3-diazepines (4).View full abstractDownload PDF (577K) -
JYOJI KURITA, HIROKAZU KOJIMA, TAKASHI TSUCHIYA1986 Volume 34 Issue 11 Pages 4871-4874
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe photo-sensitized oxygenation of monocyclic 1H-1, 3-diazepines (6) gave several fragment products (7-12). 3-Pyrrolin-2-one derivatives (7 and 8) and ethyl aminoformates (9 and 10) are assumed to originate from the initially formed 4, 7-endoperoxides (13), and vinylaminoformates (11 and 12) from the 4, 5-dioxetanes (14).View full abstractDownload PDF (510K) -
Nobuya Katagiri, Toru Haneda, Chikara Kaneko1986 Volume 34 Issue 11 Pages 4875-4878
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA new carbocyclic C-nucleoside precursor, the carbocyclic analogue of β-ribofuranosylmalonate, has been synthesized through Diels-Alder addition of cyclopentadiene to dimethyl acetoxymethylene-malonate, followed by retrograde C-C bond fissino under reductive conditions.View full abstractDownload PDF (398K) -
Tetsuro Ikekawa, Hideaki Matsuda, Mari Ohtsuka, Hiromichi Eto, Tatsuhi ...1986 Volume 34 Issue 11 Pages 4879-4882
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS3-Alkylamino-3-deoxy-D-allose and -D-glucose were synthesized from 1, 2 : 5, 6-di-O-isopropylidene-α-D-glucofuranose and investigated regarding their promotion or inhibition of plant growth using the Avena coleoptile straight growth test. The alkylamino monosaccharides with an 8 to 11 carbon alkyl chain promoted growth at a concentration of 500/3 ppm. The activity depends on the sample concentration : at a high concentration plant growth was inhibited. At a low concentration growth was promoted.View full abstractDownload PDF (413K) -
Shin-ichiro Sakai, Yukio Hitotsuyanagi, Keiichi Yamaguchi, Norio Aimi, ...1986 Volume 34 Issue 11 Pages 4883-4886
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe known tumor promoter des-O-methylolivoretin C, and a new possible tumor promoter, des-N-methylteleocidin B-4, were isolated from Streptomyces mediocidicus and the structure of the latter metabolite was elucidated by chemical correlation with the known teleocidin B-4. The structures of teleocidin B-2 and a new metabolite, olivoretin E, obtained from Streptomyces mediocidicus and Streptoverticillium olivoreticuli respectively, were determined by means of single-crystal X-ray diffraction analysis.View full abstractDownload PDF (386K) -
Kazufusa Shinomiya, Ichiro Koshiishi, Toshio Imanari, Motoko Takeda, M ...1986 Volume 34 Issue 11 Pages 4887-4888
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSUnsaturated disaccharides produced enzymatically from glycosaminoglycans were converted to fluorescent derivatives by treatment with dansylhydrazine. They were separated by high performance liquid chromatography with a TSK-gel NH2-60 column (Toyo Soda Co. Ltd.) using acetonitrile-0.1 M acetate buffer (pH 5.6) (90/20 : v/v) as the mobile phase. The detection limit was a few pmol.View full abstractDownload PDF (317K) -
Kiyoshi Iwagoe, Tenji Konishi, Shiu Kiyosawa, Yasuo Shimada, Kazumoto ...1986 Volume 34 Issue 11 Pages 4889-4891
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSNew bi-2-(2-phenylethyl) chromones, tentatively named AH10 and AH11 were isolated from Agalwood "Jinko" and their structures were determined.View full abstractDownload PDF (387K) -
Mitsuru Meda, Tohru Kodama, Takaharu Tanaka, Hajime Yoshizumi, Tsunema ...1986 Volume 34 Issue 11 Pages 4892-4895
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThree novel amino acids with insecticidal activity, isodomoic acids A, B and C, were isolated from water extracts of the red alga Chondria armata. Their structures were elucidated by spectroscopic analysis.View full abstractDownload PDF (411K) -
Sachiko Oh-ishi, Kohji Yamaki, Masahiko Hayashi, Susumu Tsushima, Hiro ...1986 Volume 34 Issue 11 Pages 4896-4898
Published: November 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSPleurisy was induced in rats by intrapleural injection of 10 uM phorbol myristate acetate (PMA) or 2 % carrageenin. Thirty minutes after PMA was administered following pretreatment with CV-3988, a specific antagonist of platelet activating factor (PFA), pleural fluid accumulation and its exudation rate were significantly suppressed. However the pleurisy induced by carrageenin was not affected by CV-3988. These results indicate that PAF may contribute to the exudation of PMA-induced pleurisy but not in carrageenin-induced pleurisy.View full abstractDownload PDF (333K)