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Volume 10, Issue 9
Displaying 1-23 of 23 articles from this issue
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Yoshihisa Mizuno, Morio Ikehara, Fumiyoshi Ishikawa, Hiroshi Ikehara1962 Volume 10 Issue 9 Pages 761-766
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESS5-and 6-Nitrobenzimidazole ribofuranosides were synthesized from chloromercury salt of 5 (6)-nitrobenzimidazole and 2, 3, 5-tri-O-benzoyl-D-ribofuranosyl chloride in 15.6% and 24.2% yield respectively. The structure of both compounds was elucidated physicochemically. 4-Nitrobenzimidazole ribofuranoside was also synthesized by an analogous reaction.View full abstractDownload PDF (911K) -
Morio Ikehara, Tohru Ueda, Kazuyoshi Ikeda1962 Volume 10 Issue 9 Pages 767-771
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSUridine was converted to 2', 3'-O-isopropylidene-5'-O-benzoyluridine and derived to 2', 3'-O-isopropylidene-4-methylthiouridine by successive thiolation and methylation. The latter compound was reacted with either CH3NH2 or (CH3)NH2 to produce 2', 3'-Oisopropylidene-N-methyl-or N, N-dimethylcytidine respectively. N-Methyl-and N, Ndimethylcytidine 5'-phosphate were synthesized by the poly-phosphoric acid method followed by the acidic removal of isopropylidene groups.View full abstractDownload PDF (1037K) -
Yuriko Kato1962 Volume 10 Issue 9 Pages 771-788
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSPhysical constants, such as surface tension, solubilization of pigments, polaography, refractive index, and viscosity, were measured of aqueous solution of 14 kinds of glycols of different number of carbon atoms, from propanediol to dodecanediol.
Glycols with hydroxyls on either terminal ends or in 1, 2-positions showed a break point in the foregoing physical constants and were considered to form a micelle-like structure.
Glycols with one hydroxyl at a terminal end and the other in a median position also forms a micelle-like structure but those having both hydroxyls in median positions and none at the terminal position do not form such a structure.
The concentration of glycols at which they form a micelle-like structure decreases with increasing number of carbon atoms and the concentration of dodecanediol becomes approximately equal to the critical micelle concentration of nonionic surfactant.View full abstractDownload PDF (2025K) -
Tohru Ueda1962 Volume 10 Issue 9 Pages 788-791
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe reaction of 5-bromo-2', 3'-isopropylideneuridine and dimethylamine gave 5-dimethylamina derivative and this was phaspharylated ta 5-dimethylaminauridine 5'-phosphate by polyphosphoric acid. 3-Methyluridine 5'-phosphate was also synthesized from 3-methyl-2', 3'-isopropylideneuridine by polyphosphoric acid.View full abstractDownload PDF (634K) -
Kazuko Narahashi1962 Volume 10 Issue 9 Pages 792-803
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe structures of orixidine and orixidinine, both demethylation products of orixine, were discussed and their 2(1H)-quinolone structures were established. It is assumed that orixidine and orixidinine should have structures (IV) and (XIII), respectively, while that of the isomeric transformation product of (XIV), iso-N-methylorixidinine, structure (XVI).View full abstractDownload PDF (2129K) -
Hiroshi Mitsuhashi, Ikuko Takemori, Yuzuru Shimizu, Taro Nomura, Emiko ...1962 Volume 10 Issue 9 Pages 804-808
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe whole plant of Marsdenia tomentosa DECNE. was proved to contain a glycoside mixture which showed strong Keller-Kiliani reaction, suggesting the presence of 2-desoxy sugars. The suger part which was obtained by acid hydrolysis was found to be glucose and cymarose by the paper chromatography compared with the authentic specimens. The aglycones were presumed to be esters. Their alkaline hydrolysis afforded two kinds of crystals, tomentogenin, a new aglycone (m.p. 247-249°) and sarcostin (m.p. 150°/245-250°) and from acidic portions tiglic acid, isovaleric acid, and acetic acid were found.View full abstractDownload PDF (877K) -
Hiroshi Mitsuhashi, Yuzuru Shimizu, Emiko Yamada, Ikuko Takemori, Taro ...1962 Volume 10 Issue 9 Pages 808-811
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe paper chromatographic separation of the polyhydroxy steroids in Asclepiadaceae plant was established. By this method, three aglycones were newly found in Cynanchum caudatum. The deacylcynanchogenin was proved to be identical with lineolon from Pachycarpus lineoratus.View full abstractDownload PDF (680K) -
Hiroshi Mitsuhashi, Taro Nomura, Yuzuru Shimizu, Ikuko Takemori, Emiko ...1962 Volume 10 Issue 9 Pages 811-817
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe stems and leaves of Metaplexis japonica MAKINO were proved to contain glycoside mixture. The glycoside showed the Keller-Kiliani reaction, suggesting the presence of 2-desoxy-sugar. The sugar portion of the glycoside was found to be D-cymarose and D-digitoxose by paper partition chromatography when compared with the authentic specimen. Five kinds of crystal, such as crystal No, 1, m. p.194-196°, crystal No.2, m. p.248/154°, crystal No.3, m. p.234-237°, crystal No.4, m. p.245°, and crystal No.5, m. p.264°, were isolated by adsorption chromatography using alurnina, and partition chromatography over Celite as a carrier. Crystal No.2 was identified to be sarcostin by the mixed melting point determination and the paper chromatography.View full abstractDownload PDF (1099K) -
Hiroshi Mitsuhashi, Teiko Hiroshige, Ikuko Takemori, Yuzuru Shimizu, T ...1962 Volume 10 Issue 9 Pages 818-822
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe stems and leaves of Cynanchum caudatum MAX. were proved to contain a glycoside mixture. The sugar portion of the glycoside was found to be D-cymarose by paper partition chromatogoraphy comparing with an authentic specimen.
Six kinds of aglycone, such as deacylcynanchogenin, sarcostin, crystal, m. p.215-220°, and other 3 spots were found by paper partition chromatography. They were isolated by adsorption chromatography using alumina, and partition chromatography over Celite as a carrier.View full abstractDownload PDF (639K) -
Harutada Negoro, Shogo Ueda, Toshihiko Hoshi1962 Volume 10 Issue 9 Pages 823-827
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSDissociation constants of the complex between pyrazine-or pyridine-monocarboxamide and Na-PAS in aqueous solution (K) were obtained at various temperatures (T) mthe absorption spectra measurment, then heats of complex formation ΔHc were evaluated from the correlation between log K and 1/T. Thus obtained, ΔHc value by the spectral method exceedingly differs from that thermal method considering the experimental error, so the discussion was made on this reason.View full abstractDownload PDF (571K) -
Yukio Kameda, Katsuhiko Matsui, Yukio Kimura, Etsuko Toyoura, Eiji Tak ...1962 Volume 10 Issue 9 Pages 827-830
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSThe metabolic activities of 3 strains (KT-303, KT-304, and KT-305) of soil bacteria were tested on tryptophan and its benzoyl derivatives (Table I), and it was found that KT-303 and KT-305 metabolized benzoyl-DL-tryptophan to produce L-tryptophan and benzoyl-D-tryptophan respectively.
Two strains (KT-230 and KT-231) of soil bacteria had the activity to metabolize benzoyl derivatives of 2-aminohexanedioic acid and 2-aminooctanoic acids to yield L-2-aminohexanedioic acid, N-benzoyl-D-2-aminohexanedioic acid, L-2-aminooctanoic acid, and N-benzoyl-D-2-aminooctanoic acid respectively.View full abstractDownload PDF (716K) -
Yukio Kameda, Tomoo Omori1962 Volume 10 Issue 9 Pages 831-833
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSAcertain strain (KT-313) isolated from soil had the metabolic activity shown in Table I and could metabolize di-N2, N6-benzoyl-DL-lysine (I) and N2-phenacyl-N6-benzoyl-DL-lysine (II) to produce N6-benzoyl-L-lysine (III), di-N2, N6-benzoyl-D-lysine (IV) and N2-phenacyl-N6-benzoyl-D-lysine (V), respectively. KT-313 seemingly belongs to the Pseudomonas group. It is of interest that KT-313 hydrolyzed benzoyl (III B) and phenacyl (III P) derivatives of N6-benzoyl-L-lysine (III), while KT-301 hydrolyzed (III B), but not (III P), and KT-311 hydrolyzed (III P), but not (III B).View full abstractDownload PDF (509K) -
Tchan Gi Bak, Shigeaki Kuwano1962 Volume 10 Issue 9 Pages 833-841
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSGallic acid and d-catechin inhibitions of glutamic and arginine decarboxylases of Escherichia coli occur in both reversible and irreversible manners. Gallic acid competes with the substrate in glutamic decarboxylase and with pyridoxal phoshate in arginine decarboxylase, whereas the interactions of d-catechin in both enzymes are of noncompetitive nature with respects to both substrates and pyridoxal phosphate. Gallicacid and d-catechin combine with glutamic decarboxylase protein at different sites.View full abstractDownload PDF (1552K) -
Hiromu Mori, Vipichandra S. Gandhi, Erwin Schwenk1962 Volume 10 Issue 9 Pages 842-851
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSSome 4, 4-dimethy1-2-hydroxy-Δ1-3-one type steroids (diosphenols) were prepared as potential tumor growth inhibiting chemotherapeuticals modeled on the cancer inhibiting elatericin B. These substances were obtained from 4, 4-dimethyl-3-oxo steroids by selenium dioxide oxidation, by a method via the 2-bromo compound, by a method via the 2-oximino compound or by autoöxidation. The last two procedures were found to be the most suitable for the preparation of the desired substances.
The diosphenols we obtained were as follows: 2-hydroxylanosta-1, 8, 24-trien-3-one (VIa), 2-hydroxylanosta-1, 8-dien-3-one (VIb), 2-hydroxy-3-oxo-4, 4, 14α-trimethyl-Δ1, 8-5α-choladienicacid (VId), 2, 17β-dihydroxy-4, 4-dimethylandrosta-1, 5-dien-3-one (XVIa), 2-hydroxy-4, 4-dimethyl-22α-spirosta-1, 5-diene-3-one (XVIc), 3-oxo-2, 12α-dihydroxy-4, 4-dimethyl-Δ1, 5-choladienic acid (XXIa), 2-hydroxy-3, 12-dioxo-4, 4-dimethyl-Δ1, 5-choladienic acid (XXVa), and 2-hydroxy-4, 4-dimethylergosta-1, 5, 7, 22-tetraen-3-one (XXVIII). 4-Hydroxy-3, 12-dioxo-Δ4-cholenic acid (XXVII) was also prepared.View full abstractDownload PDF (1974K) -
Kohzoh Okada1962 Volume 10 Issue 9 Pages 852-856
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSA synthesis of 3-methyl-9, 10-methylenedioxy-1, 2, 3, 3a, 4, 5, 11b, 11c-octahydro-7H-pyrrolo [3, 2, 1-de] phenanthridine (XIV) having common hydropyrrolophenanthridine skeleton with several of the Amaryllidaceae alkaloid such as lycorine, pulviine, caranine etc., was described. 2-(3, 4-Methylenedioxyphenyl)-5-methylcyclohexanone (VI) prepared from safrole was used as the starting material. This synthesis had recourse to the fact that the starting ketone underwent the Mannich reaction with formaldehyde and dimethylamine at its 6-position and not at 2-position to give 2-3, 4-methylenedioxyphenyl-5-methyl-6-dimethylaminomethylcyclohexanone (VII). This fact was evidenced by the ultraviolet absorption date showing the presence of an ethylene bond conjugated to the aromatic ring in the unsaturated lactam (IX) prepared from (VI) via the 2-oxo-cyclohexaneacetonitrile (VIII) by Campbell cyclization. Catalytic hydrogenation followed by lithium aluminium hydride reduction converted (VIII) into octahydroindole derivative (XIII) through the saturated lactam (XII). The ultimate base (XIV) was readily obtained from (XIII) by the conventional Pictet-Spengler method.View full abstractDownload PDF (898K) -
Kyosuke Tsuda, Susumu Ikuma, Masaaki Kawamura, Ryuji Tachikawa, Yoshih ...1962 Volume 10 Issue 9 Pages 856-865
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
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Kyosuke Tsuda, Susumu Ikuma, Masaaki Kawamura, Ryuji Tachikawa, Tetsuo ...1962 Volume 10 Issue 9 Pages 865-867
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSIn der vorhergehenden Mitteilung hatten die Autoren darauf hingewiesen, daß es sich bei der Struktur der C9-Base um 2-Amino-6-hydroxymethyl-8-chinazolinol (VIIb) handeln kann.
In dieser Arbeit berichten die Autoren über die Totalsynthese des C9-Base-methyläthers (VIIa): Als Ausgangsmaterial diente den Autoren das leicht zugängliche 5-Methoxy- iso-phthaloylchlorid (I), über dessen Herstellung bereits von Calandra, et al. berichtet worden ist. Durch Reduktion von (I) mittels Lithium-tri-tert-butoxyaluminiumhydrid in Diglyme wurde 5-Methoxy-iso-phthalaldehyd (II) und daraus wiederum durch Nitrierung sein 4-Nitroderivat (III) erhalten. Zur Bestimmung der Einführungsstelle der Nitrogruppe ließ sich das (III) durch Oxydation mittels Silberoxyd und darauffolgende Veresterung in den bekannten 5-Methoxy-4-nitro-iso-phthaloyl-dimethylester (VIIIb)überfuhren. Die Ferrosulfat-Reduktion von (III) ergab 4-Amino-5-methoxy-iso-phthalaldehyd (IV), der bei der partiellen Reduktion mittels Lithium-tri-tert-buthoxyalumilliumhydrid in Diglyme unter geeigneten Bedingungen ein Gemisch von 2-Amino-5-hydroxymethyl-3-methoxybenzaldehyd (V) und 4-Amino-5-hydroxyrnethyl-3-methoxybenzaldehyd (VI) ergab. Diese beiden Aldehyde ließen sich durch Chromatographie mittels Aluminiunzoxyd trennen und in reiner Form gewinnen.(V) unterschied sich durch sein für die o-Aminobenzaldehydgruppierung charakteristisches IR-Spektrum und gab bei der Cyclisation mit Guanidin das 2-Amino-6-hydroxymethyl-8-methoxychinazolin vom Schmp. 223-224°(VIIa).(VIIa) erwies sich nach allen Daten als identisch mit C9-Base-methyläther.View full abstractDownload PDF (533K) -
Kyosuke Tsuda, Susumu Ikuma, Masaaki Kawamura, Ryuji Tachikawa, Tetsuo ...1962 Volume 10 Issue 9 Pages 868-870
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
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Michihiro Yamada1962 Volume 10 Issue 9 Pages 871-872
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSTreatment of 14-bromocodeinone, prepared from thebaine, with zinc-dust in glacial acetic acid gave codeinone, m. p.181-182°. Codeinone was quantitatively reduced to codeine with sodium borohydride.View full abstractDownload PDF (270K) -
Katsuaki Matsui, Saburo Akagi, Fukutaro Ugai1962 Volume 10 Issue 9 Pages 872-875
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSFrom the alkaloid-free fraction of opium, β-sitosteryl-D-glucoside and its monopalmitate, (+)-10-nonacosanol, cyclo-laudenol and cyclo-artenol were isolated.View full abstractDownload PDF (697K) -
Kazuko Yamauchi, Tchan Gi Bak, Shigeaki Kuwano1962 Volume 10 Issue 9 Pages 876-878
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSPrevious studies from this laboratory have established that the alkaloid berberine inhibits two typical vitamin B6-enzymes of bacterial origins, i. e. tyrosine decarboxylase of Streptococcus faecalis and tryptophanase of Escherichia coli. Evidence has also been reported to indicate that berberine inhibits these enzymes by competing with the coenzyme pyridoxal phosphate. It has further been shown that the alkaloid, once combined with the apoenzymes, causes slow and irreversible inactivation of the enzymes.
The present investigation was undertaken to examine if berberine behaves similarly toward pig heart glutamic-aspartic transaminase, a typical B6-enzyme of mammalian tissues. The results obtained were, however, rather contrary to expectation; no inhibition by berberine could be observed in spite of many attempts. It appears, therefore, that the susceptibility of the mammalian 6 enzyme is significantly different from that of bacterial 6 enzymes for reasons to be elucidated in future.View full abstractDownload PDF (428K) -
Mitsutaka Natsume1962 Volume 10 Issue 9 Pages 879-883
Published: September 25, 1962
Released on J-STAGE: January 31, 2011
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Toshihiko Okamoto, Mitsutaka Natsume, Hiroshi Zenda, Susumu Kamata1962 Volume 10 Issue 9 Pages 883-886
Published: September 25, 1962
Released on J-STAGE: February 08, 2011
JOURNAL FREE ACCESSDownload PDF (456K)
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