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Volume 14, Issue 8
Displaying 1-20 of 20 articles from this issue
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Hiroshi Mitsuhashi, Masamichi Fukuoka1966 Volume 14 Issue 8 Pages 809-816
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe synthesis of some C/D cis-15-ketopregnane derivatives from hecogenin is described. Hecogenin was degraded to II which in turn was converted to V via III. Catalytic hydrogenation of V affords the five reduction products, VIII to XIII. VIII was dehydrogenated with selenium but Jacobs' hydrocarbon was not obtained.View full abstractDownload PDF (1076K) -
Ikuo Suzuki, Toshiaki Nakashima, Natsuko Nagasawa1966 Volume 14 Issue 8 Pages 816-823
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSCinnoline 2-oxide (I) gave 5-, 6-and 8-nitrocinnoline 2-oxides (II, III, and IV) on warming with nitric and sulfuric acids or potassium nitrate in sulfuric acid. The nitration of I with benzoyl nitrate afforded II. 5-, 6- and 8-Aminocinnolines (V, VI, VII), 6-and 8-aminocinnoline 2-oxides (VIII and IX), and 5-aminodihydrocinnoline (X) were synthesized for the determination of the structures of II, III and IV. The effect of 2-N-oxide of I in this reaction was affected by the concentration of sulfuric acid and the reaction temperature.View full abstractDownload PDF (917K) -
Goro Tsukamoto, Kiyoshi Harada, Isamu Utsumi1966 Volume 14 Issue 8 Pages 823-830
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSOxidation of O-benzoylthiamine disufide (I) with hydrogen peroxide in acetic acid yielded O-benzoylthiaminic acid (IIa) and its stereoisomerical compound (IIIa). It was confirmed that these two compounds were in the relation of geometrical isomers which have not yet been found in thiol-type thiamine derivatives : the compound obtained in this experiment was cis-2-(2-methy1-4-amino-5-pyrimidy) methylformamido-5-ben-zoyloxy-2-pentene-3-sulfonic acid (IIIa) of which olefin-CH3 and SO3- groups were in cis-configuration . Alkali decomposition of IIIa afforded cis-thiaminic acid (IIIb) corresponding to geometrical isomer of IIb. The configuration of these compounds was confirmed by elemental analyses, ultraviolet, infrared, nuclear magnetic resonance spectra and dissociation constants.View full abstractDownload PDF (969K) -
Mieko Suzuki, Eiko Akaike, Kyosuke Tsuda, Nobuo Ikekawa1966 Volume 14 Issue 8 Pages 830-833
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe quantitative analysis of sterols in the silkworm was carried out by means of gas chromatographic technique . The amount of sterol in whole body was 0.59mg. and sterol percentage of live weight was 0.066%, as an average, showing that sterol percentage in unfeeding silkworm was larger than that in feeding larva. Furthermore sterol percentage (0.024%) of blood in the silkworm was lower than that in mammals. The amount of cholesterol calculated from total sterol in the whole body was larger than threshold amount of brain hormone cholesterol in the silkworm for the induction of imaginal development On the other hand, the critical period of the brain hormone for the development was coincided with time of sudden increase of blood sterol.View full abstractDownload PDF (558K) -
Nobuo Ikekawa, Mieko Suzuki, Masatoshi Kobayasi, Kyosuke Tsuda1966 Volume 14 Issue 8 Pages 834-836
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSConversion of β-sitosterol to cholesterol in the silkworm was demonstrated using 3H-β-sitosterol. After ingestion of 3H-β-sitosterol in the larva, the ether extract of homogenized larva was fractionated on alumina. The sterol fraction was separated into cholesterol and β-sitosterol by gas chromatography and the radioactivity of each collected fraction was counted. The strong radioactivity of the larval cholesterol fraction suggested that larva is able to convert β-sitosterol in the diet to cholesterol. But in the pupa incorporation of 3H-β-sitosterol into cholesterol in free fraction was observed, while that in sterol ester fraction was not.View full abstractDownload PDF (514K) -
Mieko Suzuki, Nobuo Ikekawa, Eiko Akaike, Kyosuke Tsuda1966 Volume 14 Issue 8 Pages 837-842
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe chemical structure of hydrocarbons in the silkworm was shown as comparing with that in the mulberry leaf by means of gas chromatographic technique and mass spectrometry. The hydrocarbons from both the silkworm and mulberry leaf consisted of a mixture of odd-and even-numbered carbons and major hydrocarbons in the wings were C34 to C36 those in both blood and larva, C21 to C27, and those in mulberry leaf, C16 to C20. Large hydrocarbons, C32, C34, C38, C40 and C41, were found in the wings.View full abstractDownload PDF (700K) -
M.E. Omar Abdul-Mohsen, Shun-ichi Yamada1966 Volume 14 Issue 8 Pages 842-855
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA new type of ring closure has been established for the synthesis of some 1-substituted-6, 7-dimethoxy-3, 4-dihydroisoquinoline derivatives through desulfurization of N- (3, 4-dimethoxyphenethyl) thioamides. Mercuric chloride proved to be the only effective desulfurizing agent which produces the optimum yield of cyclized products when three moles of it are used for each mole of thioamide in acetonitrile. A reaction mechanism was tentatively proposed from the intermediates. Several organic mercurial products such as II, VI and VII were also obtained.View full abstractDownload PDF (1794K) -
M.E. Omar Abdul-Mohsen, Shun-ichi Yamada1966 Volume 14 Issue 8 Pages 856-861
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThree new N-[2-(3-indolyl)ethy1] thioamides (IIa∼c) and N-(methylthiocarbony1) tryptophan methyl ester (III) were conveniently prepared according to our general procedure of synthesizing thioamides. The cyclodesulfurization of IIa∼c was successfully accomplished in high yield to the corresponding 1-subsituted-3, 4-dihydro-9H-pyrido[3, 4-b]-indole derivatives (IVa∼c). In addition, III was cyclized to give a mixture of both 1-methy1-3, 4-dihydro-9H-pyrido[3, 4-b]indole-3-caroxylic acid (Vb), and its methyl ester (Va) in excellent yield.View full abstractDownload PDF (918K) -
Eizo Hirai1966 Volume 14 Issue 8 Pages 861-865
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe behavior of 4-amino-5-carboxy-2-methylpyrimidine (ACMP) was compared with those of 2-aminoisonicotinic acid (ANA) and 2-aminoisonicotinic acid (AINA) in water. The behaviors of these compounds were investigated spectrophotometrically by comparison with those of the corresponding ethyl ester and 1-methyl betaine. The Edsall-Blanchard equation was used to evaluate the equilibrium constants, Kz between zwitterion from and uncharged from in water. The evaluated Kz values indicated that ACMP, ANA and AINA existed almost completely in the zwitterion form in water, respectively. This result was in good agreement with the spectrophoto-chemical observations.View full abstractDownload PDF (698K) -
Masuo Morisaki, Hiroko Izawa, Kyosuke Tsuda1966 Volume 14 Issue 8 Pages 866-872
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSEs wird die Aromatisierungsreaktion von 2 (oder 4)-Methylcholesta-1, 4-dien-3-on mittels Zinkstaub beschrieben. Bei 4-Methylcholesta-1, 4-dien-3-on verlauft die reduktive Aromatisierungsreaktion unter Abspaltung der C-C Bindung an C10-C19 oder C10-C9. Aber bei 2-Methylcholesta-1, 4-dien-3-on findet auβer der obenerwahnten reduktiven Aromatisierung noch die Dienon-Phenol-Umlagerungsreaktion statt.View full abstractDownload PDF (1020K) -
Hiroko Izawa, Masuo Morisaki, Kyosuke Tsuda1966 Volume 14 Issue 8 Pages 873-877
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSEs wird die Aromatisierungsreaktion von Cholesta-2, 4-dien-1-on mittels Zinkstaub beschrieben. Dabei wird bewiesen, daβ die Reaktion auf analoge Weise wie die Dienon-Phenol-Umlagerung durch Angriff des Zink-Ions verlauft und schlieβlich 19-Nor-4-methylcholesta-1, 3, 5(10)-trien-3-ol ergibt.View full abstractDownload PDF (783K) -
Hiroaki Matsuda1966 Volume 14 Issue 8 Pages 877-883
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA study of polyphenolic compounds and shikimic acid in the leaves of Rhus and Poupartia (Anacardiaceae), Sapium, Ricinus and Aleurites (Euphorbiaceae) have been undertaken. From the results obtained on the constituents of these plants, corilagin, an ellagitannin, proved to be common except in Rhus chinensis. Shikimic acid is also common except in Poupartia. Flavonoid compounds consisted of glycosides of flavonols and apigenin.View full abstractDownload PDF (1066K) -
Haruaki Yajima, Koichi Kawasaki, Masao Koida1966 Volume 14 Issue 8 Pages 884-890
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe N-acetyl group of melatonin was replaced with a histidylphenylalanylarginyl moiety . The product, N-(histidyenylalanylarginy1)-5-methoxytryptamine, reversed the darkening action of α-melanocyte-stimulating hormone (MSH) on frog-skin in vitro in contrast to the closely related tetrapeptide, histidylphenylalanylarginyltryptophan which exhibits intrinsic MSH activity. The synthetic intermediates, N-arginy1-5-meth-oxytryptamine and N-(phenylalanylarginyl)-5-methoxytryptamine also reversed the action of α-MSH. The color lightening potency of these compounds was about one millionth that of melatonin.View full abstractDownload PDF (1001K) -
Hiroshi Hikino, Keitaro Aota, Tsunematsu Takemoto1966 Volume 14 Issue 8 Pages 890-896
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSCyperotundone, the constituent of nutgrass (Cyperus rotundus (Cyperaceae)), has been shown to have the stereostructure I as follows : Spectral determinations of it and its derivatives revealed the presence of a 2-methyl-3-substituted cyclopent-2-enone system with a methylene αto the carbonyl. The carbon skeleton was established by transformation to the isopatchoulane (VI) derived from patchouli alcohol (VII). The absolute configuration of the C-11 bridge was deduced from the above transformation and a positive Cotton effect of the optical rotatory dispersion of the ketone (X) and that of the C-10 methyl from examination of the NMR methyl signals.View full abstractDownload PDF (1036K) -
Nobuko Kataoka, Akira Imamura, Yutaka Kawazoe, Goro Chihara, Chikayosh ...1966 Volume 14 Issue 8 Pages 897-902
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSUV-irradiation of 4-nitroquinoline 1-oxide in solutions, that is, in dioxane, in benzene, and in hexane, induced stable radicals which were investigated by ESR spectroscopy. Hyperfine structures of spectra thus obtained are different from each other depending on the sort of the solvents used. Determination of these radical structures were carried out by help of isotope-containing 4-nitroquinoline 1-oxides and, in particular, the structure of dioxane type radical was proposed, based on spectral changes by isotope replacement.View full abstractDownload PDF (734K) -
Shigeharu Inouye1966 Volume 14 Issue 8 Pages 902-909
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe preparation of the title compounds from the respective methyl 3-acetamido-3-deoxy-α-D-hexopyranosides was described. Introduction of an amino group at C6 was confirmed by nuclear magnetic resonance spectroscopy and dissociation constants. De-N-acetylation of methyl 3-acetamido-6-azido-3, 6-dideoxy-α-D-glucopyranoside by hydrazine was accompanied with reduction of the azido group to give directly methyl 3, 6-diamino-3, 6-dideoxy-α-D-glucopyranoside. Treatment of methyl 3-acetamido-3-deoxy-2, 6-di-O-p-tolylsulfonfl-α-D-glucopyranoside with sodium azide afforded, via an 2, 3-oxazolinium intermediate, methyl 3-acetamido-6-azido-3, 6-dideoxy-α-D-mannopyranoside. The isolation of a new compound, methyl 3-amino-3-deoxy-β-L-glucopyranoside from nitromethane condensation products was added.View full abstractDownload PDF (1153K) -
Kenji Suzuki1966 Volume 14 Issue 8 Pages 909-914
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe synthesis of three peptides related to the C-terminus of B-peptide of ox cofibrin (positions 16∼21, 15∼21, and 13-21) is described. The biological activity of the peptides on isolated mouse ileum is reported.View full abstractDownload PDF (897K) -
Katsuichi Shuto, Kimiko Matsuo, Masamichi Tsuboi1966 Volume 14 Issue 8 Pages 915-916
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (356K) -
Takeo Naito, Toru Yoshikawa1966 Volume 14 Issue 8 Pages 918-921
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (625K) -
Shun-ichi Yamada, Kiyoyasu Ishikawa, Kazuo Achiwa1966 Volume 14 Issue 8 Pages 921-924
Published: August 25, 1966
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (491K)
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