All issues
Volume 67, Issue 12
Displaying 1-4 of 4 articles from this issue
- |<
- <
- 1
- >
- >|
-
Yoshihiko MURATA, Kenji KUSAJIMA, Fujio OOISI, Yasunori HIRAYAMA, Nobu ...1992 Volume 67 Issue 12 Pages 747-754
Published: December 15, 1992
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSWe investigated epidemiologic and clinical aspects of tuberculosis in young generation and pointed out probrems in ambulatory treatment.
In six general hospitals in Tokyo, 418 cases of tuberculosis (285 males and 133 females) were diagnosed between 1983 and 1991. They were divided into three groups; 1) young group, 10 to 29 yr (62 cases), 2) middle age group, 30 to 69 yr (255 cases), 3) elderly group, above 70 yr (101 cases). And the risk of clinical breakdown, method of case finding, radiological findings, extra-pulmonary lesions, method of diagnosis, relationship with epidemics, patient's delay, doctor's delay, drug regimens and patient, s compliance in each group were investigated. In addition, after completion of therapy we sent them survey questions about relapse and attack of tuberculosis among their families.
Results were followings. 1) Estimated risk of clinical breakdown by age was calculated as follows, (the number of patients)/(the population of Tokyo)/(estimated incidence of infection). This was extreamly high in young group. 2) Sixteen percent of patients in young group were related with epidemics and another eight percent with familial outbreaks. 3) Although many patients in young group showed focal lesions in chest radiographies, the rate of symptomatic patients was 61% and that was almost same as in other groups. 4) The rate of patients showing atypical radiographic findings, extra-thoracic lymphadenopathy and idiopathic pleuritis were relatively high in young and elderly group. 5) Results of survey questions showed no relapse among ambulatory treated patients. Familial outbreaks (three cases) were thought to be caused by long patient's delay and not by amulatory treatment of smear-positive patients. 6) The largest problem in ambulatory treatment of young tuberculosis patients was poor compliance.View full abstractDownload PDF (1238K) -
Katsuhiko TSUKAGUCHI, Takahiro YONEDA, Masanori YOSHIKAWA, Takeshi TOK ...1992 Volume 67 Issue 12 Pages 755-760
Published: December 15, 1992
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSPatients with diabetes mellitus (DM) show an increased susceptibility to bacterial infections due to the presence of neutrophil dysfunction. Susceptibility to tuberculosis has also been reported in such patients, however, the reason remains unclear.
This study measured the production of interleukin-1β (IL-1β), tumor necrosis factor α (TNF α) and interleukin-6 (IL-6) by the peripheral monocytes of patients diagnosed with pulmonary tuberculosis accompanied by DM (TB+DM) and patients without DM complications (TB) using age-matched, healthy control subjects for comparison. Also examined was the relationship between cytokine production and DM control. The results were as follows:
(1) The production of IL-1β, TNF α and IL-6 in TB patients was significantly higher than that observed in the healthy control subjects.
(2) The production of IL-1β, TNF α and IL-6 in TB+DM patients was significantly lower than that observed in the TB patients.
(3) The production of IL-1β and TNF α in TB+DM patients with poor control was significantly lower than that observed in the patients with good control.
(4) The TNF α production had a significant inverse correlation to HbA1c in the TB+DM patients.
This study demonstrated that the production of cytokines is impaired in TB+DM Patients and suggests a close correlation between tuberculosis immunity and DM.View full abstractDownload PDF (857K) -
Kouichi TOMODA, Takahiro YONEDA, Hirofnmi AKO, Eri YOSHIDA, Toshi SUGA ...1992 Volume 67 Issue 12 Pages 761-765
Published: December 15, 1992
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThree young adults advanced pulmonary tuberculosis due to delay of therapy were reported. In case 1 and 3, their delays resulted from difficulty in diagnosis, in case 2, from neglecting medical counseling. Each cases revealed bilatelal diffuse shadows on chest roentgenograms on admission, which were typical shadows of advanced pulmonary tuberculosis.
Malnutrition might contribute to the development of the diseases, which were improved by anti-tuberculosis therapy and hyperalimentation therapy. These cases were suggested some clinical problems characteristic of pulmonary tuberculosis of young adults.
View full abstractDownload PDF (3880K) -
Teruo AOYAGI1992 Volume 67 Issue 12 Pages 767-808
Published: December 15, 1992
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (8004K)
- |<
- <
- 1
- >
- >|