Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Volume 46 , Issue 23
Showing 1-15 articles out of 15 articles from the selected issue
REVIEW ARTICLE
  • Yasuharu Tokuda, Seishirou Miyagi
    2007 Volume 46 Issue 23 Pages 1885-1891
    Published: 2007
    Released: December 03, 2007
    JOURNALS OPEN ACCESS
    Among the various diagnostic strategies of chronic obstructive pulmonary disease (COPD), physical diagnosis is the quickest and requires no extra cost. Rapid physical diagnosis of COPD in primary care practice can lead to earlier actions of preventive measures and counseling for patients. Further, rapid physical diagnosis of COPD in an emergency department is also crucial for timely use of potentially lifesaving therapy specific for COPD patients. In this review, we will present a broad scope of physical findings for rapid physical diagnosis of COPD.
    Download PDF (1280K)
ORIGINAL ARTICLES
  • Satoru Yamada, Mari Watanabe, Osamu Funae, Yoshihito Atsumi, Ryuji Suz ...
    2007 Volume 46 Issue 23 Pages 1893-1897
    Published: 2007
    Released: December 03, 2007
    JOURNALS OPEN ACCESS
    Aim The effect of rapid-acting insulin secretagogues (glinides) on glycemic control when included with insulin therapy for type 2 diabetes remains uncertain. To examine this, we added glinide once a day to twice daily injections of premixed insulin.
    Research Design and Methods Seventy-four type 2 diabetic patients, taking twice daily injections of premixed insulin and whose diabetic control was stable, were registered at 6 independent institutions. After a 3-month observation period, 60 patients were administered 10 mg mitiglinide or 90 mg nateglinide at lunchtime without changing their insulin regimen. After 12 weeks, administration of glinide was discontinued and observation was continued. HbA1c levels were measured at the start of glinide administration, after 12 weeks of glinide , and at 12 weeks after discontinuation.
    Results HbA1c improved from 7.72±0.66% to 7.55±0.71% (p <0.01) at Week 12 of glinide administration. Twelve weeks after discontinuation, HbA1c returned to the baseline level (7.72±0.81%).
    Conclusion This study indicates that the addition of glinide once a day at lunchtime to twice daily injections of premixed insulin is effective for the treatment of type 2 diabetes.
    Download PDF (163K)
  • Nobuyuki Takasu, Hiroyuki Yogi, Masaki Takara, Moritake Higa, Tsuyoshi ...
    2007 Volume 46 Issue 23 Pages 1899-1904
    Published: 2007
    Released: December 03, 2007
    JOURNALS OPEN ACCESS
    Background Motorization and supermarket-proliferation affect lifestyles. About 15 years ago, Okinawans went to several shops on foot, but now they go to supermarkets by car. The influences of these changes on the prevalence of diabetes are uncertain.
    Objective and Measurements The influence of motorization and supermarket-proliferation on the prevalence of diabetes was studied in the inhabitants of a town on Okinawa, Japan. Measurements were composed of anthropometry and blood chemistry. Participants were asked where they buy food and daily necessities (several shops or a supermarket) and how they get there (by car or on foot).
    Design Serial cross-sectional.
    Participants Inhabitants of the island of Okinawa were studied.
    Results In 1991, 24% went to several shops and 20% to a supermarket. However, in 2004, only 3.1% went to several shops and 83% to a supermarket. In 1991, 55% went to shopping places on foot and 38% by car. However, in 2004, only 14% went on foot and 76% by car. The prevalence of diabetes in Okinawa increased from 4.7% in 1991 to 8.4% in 2004. The prevalence of diabetes correlated positively with the percent of inhabitants going to supermarkets, and those going there by car. In 1991, the prevalence of type 2 diabetes was 4.7% in men and 4.6% in women; no difference was noted between men and women. In 2004, the prevalence of type 2 diabetes increased to 9.2% in men and to 7.5% in women. The increase in the prevalence of type 2 diabetes from 1991 to 2004 was higher in men than in women.
    Conclusions About 15 years ago, Okinawans went to shops on foot, but now they go to supermarkets by car. The prevalence of diabetes is increasing. Motorization and supermarket-proliferation are associated with the increases of the prevalence of diabetes. The increase in diabetes prevalence was higher in men than in women.
    Download PDF (303K)
  • Keiichiro Sakuma, Hajime Nakamura, Takayuki Nakamura, Yuma Hoshino, Sh ...
    2007 Volume 46 Issue 23 Pages 1905-1909
    Published: 2007
    Released: December 03, 2007
    JOURNALS OPEN ACCESS
    Objective Interstitial lung disease (ILD) is a severe adverse event of gefitinib therapy. However, the mechanism still remains unclear. The objective of this study was to examine whether or not oxidative stress, one of the common factors in drug-associated ILD, is involved in the pathogenesis of gefitinib-induced ILD.
    Patients and Methods Using an enzyme-linked immunosorbent assay (ELISA), we measured the concentration of serum thioredoxin (Trx), a redox-active protein with antioxidative effects, in 44 patients treated with gefitinib, including three patients who had ILD.
    Results In patients who had gefitinib-induced ILD, serum Trx levels were significantly elevated. They decreased after cessation of gefitinib therapy accompanying clinical improvement of ILD.
    Conclusion It was suggested that oxidative stress may be involved as a part of mechanisms causing or worsening gefitinib-induced ILD.
    Download PDF (569K)
CASE REPORTS
SHORT COMMUNICATIONS
PICTURES IN CLINICAL MEDICINES
feedback
Top