The homology of N-termini of histones, H2A and H4, was examined. It was proposed that the N-terminus common to both histones, “Ser
1-Gly
2-Arg
3-Gly
4-Lys
5-(X)
6-Gly
7-Gly
8-Lys
9-X
10-(X)
11-(X)
12-Lys
13-X
14-X
15-Ala
16-Lys
17”has fundamental importance to gene regulation. The acetylation of Lys residues has a significance for gene regulation in view of the location of four molecules of H2A and H4 in the nucleosome. The possibility of folding the pseudo-βαβ-structure by N-terminus of H2A was discussed.
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