Proceedings of the Japan Academy, Series B
Online ISSN : 1349-2896
Print ISSN : 0386-2208
ISSN-L : 0386-2208
Volume 83, Issue 5
Displaying 1-3 of 3 articles from this issue
  • Hiroshi OHRUI
    2007 Volume 83 Issue 5 Pages 127-135
    Published: 2007
    Released on J-STAGE: June 20, 2007
    The development of highly potent chiral discrimination methods that solve the problems of the diastereomer method, in which it is impossible to discriminate the diastereomers having chiral centers separated by more than four bonds, is described. On the basis of the results obtained, a new hypothesis, Induced Chiral Fields that the achiral reversed phase can provide chiral fields depending on the structures of the eluents, is proposed to explain the significant results of separation of the diastereomers derived from newly developed chiral and fluorescent labeling reagents and optical isomers by reversed-phase HPLC, which was hitherto impossible.

    (Communicated by Masanao MATSUI, M.J.A.)
    Download PDF (1744K)
  • Hiroshi TAKAYANAGI
    2007 Volume 83 Issue 5 Pages 136-143
    Published: 2007
    Released on J-STAGE: June 20, 2007
    The interaction between the immune and bone systems has long been appreciated, but recent research into arthritis as well as various bone phenotypes found in immune-related knockout mice has highlighted the importance of the interplay and the interdisciplinary field called osteoimmunology. In rheumatoid arthritis, IL-17-producing helper T cells (TH17) induces receptor activator of NF-κB ligand (RANKL), which stimulates osteoclast differentiation through nuclear factor of activated T cells (NFAT)c1. Accumulating evidence suggests that the immune and skeletal systems share cytokines, signaling molecules, transcription factors and membrane receptors. In addition, the immune cells are maintained in the bone marrow, which provides a space for mutual interaction. Thus, bone turns out to be a dynamic tissue that is constantly renewed, where the immune system participates to a hitherto unexpected extent. This emerging field of osteoimmunology will be of great importance not only to the better understanding of the two systems but also to the development of new treatment for rheumatic diseases.

    (Communicated by Masanori OTSUKA, M.J.A.)
    Download PDF (275K)
Original Paper
  • Toshimitsu YAMAZAKI, Yoshinori AKAISHI
    2007 Volume 83 Issue 5 Pages 144-150
    Published: 2007
    Released on J-STAGE: June 20, 2007
    We have studied the structure of K- pp comprehensively by solving this three-body system in a variational method, starting from the Ansatz that the Λ (1405) resonance (≡ Λ*) is a K- p bound state. The structure of K- pp reveals a molecular feature, namely, the K- in Λ* as an "atomic center" plays a key role in producing strong covalent bonding with the other proton. We point out that strongly bound Kbar nuclear systems are formed by "super strong" nuclear force due to migrating real bosonic particles Kbar a la Heitler-London-Heisenberg, whereas the normal nuclear force is caused by mediating virtual mesons. We have shown that the elementary process, p + p → K+ + Λ* + p, which occurs in a short impact parameter and with a large momentum transfer, leads to unusually large self-trapping of Λ* by the involved proton, since the Λ*-p system exists as a compact doorway state propagating to K-pp.

    (Contributed by Toshimitsu YAMAZAKI, M.J.A.)
    Download PDF (659K)