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Volume 29, Issue 11
Displaying 51-54 of 54 articles from this issue
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SHOZO MIYAZAKI, MIDORI OSHIBA, TANEKAZU NADAI1981Volume 29Issue 11 Pages 3414-3417
Published: November 25, 1981
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe effect of chloride ion on the dissolution properties of papaverine-HCl was studied. The solubility and dissolution rate of papaverine-HCl were decreased by the common ion effect in a medium rich in chloride ion. The effect of chloride ion on the plasma levels of papaverine-HCl was also tested in rats, and lower plasma levels were observed when the drug was administered with 0.9% NaCl than in its absence. The results suggest that it may be possible to formulate sustained release preparations of papaverine-HCl by combination with NaCl.View full abstractDownload PDF (474K) -
YASUO INUBUSHI, TAKASHI HARAYAMA, KEIICHI YAMAGUCHI, HISASHI ISHII1981Volume 29Issue 11 Pages 3418-3421
Published: November 25, 1981
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe structures of two Lycopodium alkaloids, lycothunine and lycophlegmarine, were determined by an X-ray analysis. The configurations of C3-C4 bond of fawcettimine and fawcettidine were also established.View full abstractDownload PDF (501K) -
SHINICHI UESATO, TOSHIHIRO HASHIMOTO, YOSHIO TAKEDA, KENICHI UOBE, HIR ...1981Volume 29Issue 11 Pages 3421-3424
Published: November 25, 1981
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAlong with the known hydrangenoside A (4), new glucosides of the same series, hydrangenosides B (1), C (2) and D (3), have been isolated from Hydrangea macrophylla and their absolute structures have been established. These substances are considered to be formed by an aldol-type condensation of secologanin (5) with a shikimate-malonate derived moiety followed by decarboxylation. Hydrangenoside A (4) and B (1) are stereoisomers, while hydrangenoside C (2) and D (3) are their homologues containing one fewer acetate unit and also are stereoisomers.View full abstractDownload PDF (525K) -
YOSHISUKE TSUDA, NORIAKI KASHIWABA, MICHIKO KAJITANI, JUNKO YASUI1981Volume 29Issue 11 Pages 3424-3426
Published: November 25, 1981
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSHydrogenation of the tricyclic acetal 4, which was prepared from the octalone 3 by 2 steps, yielded the trans-dihydro product 5 with high stereoselectivity, while hydrogenation of the dimethyloctalones, 8 and 9, showed low stereoselectivity. 5 was converted to the cyclopropy-decalone 2 in high yield. Reductive alkylation of 2 gave regioselectively the C1 alkylated trimethyldecalone 12, which was converted to the key intermediate to α-onocerin 16, thus illustrating potential utility of 2 in terpenoid synthesis.View full abstractDownload PDF (400K)