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Volume 29, Issue 9
Displaying 51-55 of 55 articles from this issue
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KOZO TAKAYAMA, NAOKI NAMBU, TSUNEJI NAGAI1981Volume 29Issue 9 Pages 2718-2721
Published: September 25, 1981
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSFor the analysis of interfacial transfer of indomethacin (IMC) following the dissolution of IMC coprecipitates with polyvinylpyrrolidone (PVP), a new equation based on the crystallization of IMC was derived and found to fit the results reasonably well. Therefore, the crystallization process of IMC in coprecipitates with PVP is an important factor in the analysis of interfacial transfer phenomena as well as in the analysis of dissolution behavior. The new equation might be suitable for prediction of the bioavailability of drugs in the coprecipitate system on the basis of the results of in vitro experiments.View full abstractDownload PDF (496K) -
KAZUYUKI KIZUKI, HIROSHI MORIYA1981Volume 29Issue 9 Pages 2721-2724
Published: September 25, 1981
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA potent kinin-inactivating enzyme from the mushroom Tricholoma conglobatum, Shimeji kininase, liberated angiotensin II and the dipeptide, H-His-Leu-OH, from angiotensin I. Thus, this enzyme was considered to have both kininase and angiotensin I converting activities like kininase II (angiotensin I converting enzyme, EC 3.4.15.1), which is widely distributed in mammals of various species. On the other hand, this enzyme had angiotensinase activity in addition to angiotensin I converting activity. However, the rate of angiotensin II hydrolysis was very slow as compared with that of kinin hydrolysis ; the molar ratio of angiotensin II hydrolysis to bradykinin hydrolysis was about 1 : 70.View full abstractDownload PDF (477K) -
KOJI HAYASHI, KEIJI WADA, HIROSHI MITSUHASHI, HIDEO BANDO, MUNEAKI TAK ...1981Volume 29Issue 9 Pages 2725-2730
Published: September 25, 1981
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSFour antitumor active condurangoglycosides-B0, -D0, and 20-O-methyl-and 20-iso-O-methyl-condurangoglycoside-D0 were isolated from Condurango Cortex. Their structures were established by chemical and spectral data. Their antitumor activities and toxicities are described.View full abstractDownload PDF (551K) -
YOSHINOBU MUROFUSHI, YUICHI HASHIMOTO, KOICHI SHUDO, TOSHIHIKO OKAMOTO1981Volume 29Issue 9 Pages 2730-2732
Published: September 25, 1981
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA possible activated form of 1-naphthylamine, N-hydroxy-1-naphthylamine, reacted with the C8-position of guanine in deoxyribonucleic acid (DNA). Hydrolysis of the modified DNA with nuclease and acid gave N-(guanin-C8-yl)-1-naphthylamine as a modified base. The C8-position of guanine seems to be a common site of attack on DNA by activated muta-carcinogenic aromatic amines.View full abstractDownload PDF (395K) -
KEISHIRO NAGAO, MASATO CHIBA, ISOTAKA YOSHIMURA, SANGWON KIM1981Volume 29Issue 9 Pages 2733-2735
Published: September 25, 1981
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSTotal synthesis of (±)-carpesiolin (1) is described using a new and general synthetic route to helenanolide sesquiterpenes. The scheme includes the stereocontrolled introduction of the C-10 α-methyl group in the perhydroindanone (3) and its conversion to the perhydroazulenone (4) via the regiospecific ring expansion reaction.View full abstractDownload PDF (375K)