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Volume 31, Issue 2
Displaying 51-64 of 64 articles from this issue
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YOHMEI OKUNO, KIYOSHI HORITA, OSAMU YONEMITSU1983Volume 31Issue 2 Pages 737-740
Published: February 25, 1983
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe preparation of a new macro-ring compound, 9, 18, 27-triaza-10, 19, 28-trioxo-35-pentatriacontanelactam, is described. A simple azide method in a mixed solvent system (water : dimethylformamide (DMF)=1 : 3) gave a good cyclization result, and the use of sodium or potassium cations as a template produced a 30% augmentation in the yield.View full abstractDownload PDF (535K) -
SHIGEO UKAI, TADASHI KIHO, CHIHIRO HARA, MASUYUKI MORITA, ARATA GOTO, ...1983Volume 31Issue 2 Pages 741-744
Published: February 25, 1983
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA mannan and water-soluble glucans from Dictyophora indusiata, a water-insoluble glucan from Ganoderma japonicum, a galactomannan from Cordyceps cicadae, and acidic heteroglycans from Auricularia auricula-judae and Auricularia species (Yu er), whose structural features have been reported in our previous papers of this series, were tested for antitumor activity against subcutaneously implanted sarcoma 180 in mice by intraperitoneal administration. Considerable antitumor activity was observed with partially O-acetylated (1→3)-α-D-mannan (T-2-HN) at doses of 10 mg·kg-1·d-1×10, water-soluble (1→3)-β-D-glucans having β-1→6 linked D-glucosyl side chains (T-4-N and T-5-N) at doses 5 or 10 mg·kg-1·d-1×10, and a glucuronoxyloglucomannan (U-3-A) at doses of 25 mg·kg-1·d-1×10.View full abstractDownload PDF (532K) -
Seisho Tobinaga, Naoki Takeuchi, Toshio Kasama, Junko Yamashita, Yoko ...1983Volume 31Issue 2 Pages 745-748
Published: February 25, 1983
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSIt was found that the eremophilenolides (1) and (2), the constituents of the rhizomes of Petasites japonicus Maxim., have moderate anti-histaminic and anti-allergic activities.View full abstractDownload PDF (412K) -
RADICAL CATION INDUCED REDUCTIVE DEHALOGENATION OF ORTHO- AND PARA-HALOPHENOLS AND THEIR DERIVATIVESManabu Node, Takeo Kawabata, Keiichiro Ohta, Kohji Watanabe, Kaoru Fuj ...1983Volume 31Issue 2 Pages 749-751
Published: February 25, 1983
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSOrtho- as well as para- halophenols and their derivatives were reductively dehalogenated in high yields. These reactions proceed through a mechanism which involves initial generation of a radical cation.View full abstractDownload PDF (344K) -
Kiyoteru Ikegami, Shigeru Hirano, Gen Hasegawa1983Volume 31Issue 2 Pages 752-755
Published: February 25, 1983
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSTraxanox sodium salt pentahydrate (9-chloro-5-oxo-7-(1H-tetrazol-5-yl)-5H-[1] benzopyrano [2, 3-b] pyridine sodium salt pentahydrate, Code No. Y-12, 141) (traxanox sodium) inhibited cyclic AMP phosphodiesterase in the lungs and hearts of rats. The inhibitory effect of traxanox sodium was more potent than that of both theophylline and sodium cromoglycate, but was less potent than that of papaverine. In the low Km (2 μM) enzyme of lungs the inhibition by traxanox sodium was competitive and its inhibition constant (Ki) was 66.7 μM. Intraperitoneal injection of traxanox sodium (100 mg/kg) synergistically enhanced the isoproterenol-induced increase of cyclic AMP in the plasma of rats.View full abstractDownload PDF (434K) -
Hideaki Sasaki, Tokujiro Kitagawa1983Volume 31Issue 2 Pages 756-759
Published: February 25, 1983
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSBis (2-isocyano-2-tosylethyl) benzenes (4) reacted with benzenedicarbal dehydes (9) in the presence of sodium ethoxide as a base in refluxing ethanol to form dioxazolo-[3.3] cyclophanes (10).View full abstractDownload PDF (367K) -
Shigeyuki Kitamura, Kiyoshi Tatsumi1983Volume 31Issue 2 Pages 760-763
Published: February 25, 1983
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSRecently, we found that liver aldehyde oxidase functions as sulfoxide reductase in the presence of its electron donor. In addition, the present study provides the first evidence that a combination of liver aldehyde oxidase and milk xanthine oxidase also exhibits sulfoxide reductase activity in the presence of xanthine, an electron donor of xanthine oxidase. Based on these facts, we propose a new electron transfer system consisting of these flavoenzymes.View full abstractDownload PDF (431K) -
Kiyoshi Tatsumi, Hiroshi Yamada, Shigeyuki Kitamura1983Volume 31Issue 2 Pages 764-767
Published: February 25, 1983
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe present study shows that guinea pig and rabbit liver aldehyde oxidase in the presence of its electron donors such as aldehydes or N-heterocyclic compounds reacts as N-nitrosoreductase with N-nitroso-diphenylamine and other nitrosamines.View full abstractDownload PDF (421K) -
Akira Yoshida, Teruo Hayashi, Noriko Takeda, Sadao Oida, Eiji Ohki1983Volume 31Issue 2 Pages 768-771
Published: February 25, 1983
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSTreatment of the oxalimide 5 with triethyl phosphite formed the penem 3 and the triethoxyphosphonium ylide 7, presumably via the common carbene intermediate 10. Prolonged heating of 7 afforded 3 and its C-5 epimer. Similar reaction of the oxalimide 13 with trimethyl phosphite gave only the ylide 14, which was further heated to cyclize to the penem 15.View full abstractDownload PDF (439K) -
Yuichi Iiizumi, Kazuyuki Hirano, Mamoru Sugiura, Shiro Iino, Hiroshi S ...1983Volume 31Issue 2 Pages 772-775
Published: February 25, 1983
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe evidence for a possible role of intestinal alkaline phosphatase in the physiologic state is offered in this paper. A phosphate transport system operating at a physiological pH is found in the upper part of the small intestine where the alkaline phosphatase is maximally concentrated. The phosphate transport was affected by various inhibitors and antiserum to rat intestinal alkaline phosphatase. In conclusion, alkaline phosphatase may function not only as a hydrolytic enzyme of phosphoester but also as a phosphate transporter in the physiologic state.View full abstractDownload PDF (475K) -
Shigeyuki Kitamura, Noriko Narai, Misuzu Hayashi, Kiyoshi Tatsumi1983Volume 31Issue 2 Pages 776-779
Published: February 25, 1983
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe present paper is the first description of mammalian nitroreductases acting upon nitropolycyclic aromatic hydrocarbons. Rabbit liver microsomal and cytosolic fractions have ability to reduce 1-nitropyrene or 2-nitrofluorene to the corresponding amine under anaerobic conditions. The nitroreductase activity in the former fraction is mainly due to a cytochrome P-450 system and that in the latter fraction is due to aldehyde oxidase.View full abstractDownload PDF (434K) -
Takashi Tanaka, Osamu Tanaka, ZhongWen Lin, Jun Zhou, Hiroyuki Ageta1983Volume 31Issue 2 Pages 780-783
Published: February 25, 1983
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSFrom a Chinese plant drug, Bai-Yun-Shen (roots of Salvia digitaloides), a new sweet glycoside named baiyunoside (1) was isolated. The structure of the acid-unstable aglycone of 1 named baiyunol (2) was elucidated by MS and NMR spectroscopy especially by comparison with the 13C chemical shifts of β-onocerin (3). The structure of 1 was determined to be β-D-xylopyranosyl (1→2)-β-D-glucopyranoside of 2 by MS and NMR spectroscopy. Besides this sweet principle (1), several bitter iridoid glucosides were also isolated from this plant. Two of these glucosides were identified as shanzhiside methyl ester (13) and its 8-O-acetate (=acetylbarlerin, 10), respectively. A new glucoside (9) was formulated as 6-O-syringyl-8-O-acetyl shanzhiside methyl ester by the correlation with 13.View full abstractDownload PDF (475K) -
Masaichiro Masui, Takahiro Ueshima, Shigeko Ozaki, Takaji Fujiwara, Ke ...1983Volume 31Issue 2 Pages 784-786
Published: February 25, 1983
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe structure of the product of the reaction of acetylsalicyloyl-chloride with N-phenylhydroxylamine was suggested by electrochemical method to be an O-acetylhydroxamic acid derivative, and its molecular structure was confirmed by X-ray analysis.View full abstractDownload PDF (374K) -
Hiromichi Tanaka, Yuko Uchida, Misao Shinozaki, Hiroyuki Hayakawa, Aki ...1983Volume 31Issue 2 Pages 787-790
Published: February 25, 1983
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS6-Chloro-9-(2, 3-O-isopropylidene-β-D-ribofuranosyl) purine (1) was found to be a suitable substrate for the preparation of C-8 substituted purine nucleosides. Thus, upon lithiation of 1 with LDA and successive reaction with various types of electrophiles, the C-8 substituted products were obtained. The C-6 chlorine atoms in these products were readily replaced by an amino group, a mercapto group, or hydrogen, providing a facile preparation of 8-substituted adenosines, 6-thioinosines, or nebularines.View full abstractDownload PDF (399K)