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Volume 35, Issue 6
Displaying 51-78 of 78 articles from this issue
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AKINORI KUBO, NAOKI SAITO, HIDEKAZU YAMATO, YUKO KAWAKAMI1987 Volume 35 Issue 6 Pages 2525-2532
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSA simple and efficient synthesis of a variety of (Z) -3-arylidene-6-arylmethyl-2, 5-piperazine-diones 10 having highly oxygenated benzene rings, and regioselective benzylation at position 4 are described.View full abstractDownload PDF (1390K) -
FUJIO MURAI, MOTOKO TAGAWA, HIROYUKI INOUYE, TOSHIMASA ISHIDA, MASATOS ...1987 Volume 35 Issue 6 Pages 2533-2537
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSA new iridoid glucoside, named nepetariaside, was isolated from Nepeta cataria L. and its absolute structure was elucidated by chemical, spectral and X-ray crystallographic analysis.View full abstractDownload PDF (742K) -
ATSUKO NODA, TOSHIAKI SENDO, KOHJI OHNO, HIROSHI NODA, SHIGERU GOTO1987 Volume 35 Issue 6 Pages 2538-2544
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSThe relationship between the metabolism and hepatotoxicity of hydrazine (Hz) was studied in an isolated rat hepatocyte system. After incubation at 37°C for 60 min; the concentration of Hz decreased to 34% of the initial value. (from 98 to 33 nmol/ml). A further pronounced loss was observed when Hz was incubated with hepatocytes isolated from rats which had been pretreated with phenobarbital (PB) or rifampicin. Since metyrapone and piperonylbutoxide inhibited the metabolism in the systems obtained from both PB-pretreated rats and untreated rats, an important role of hepatic cytochrome P-450 in Hz oxidation was suggested. The difference spectrum of Hz with cytochrome P-450 in isolated rat hepatocytes demonstrated the formation of complexes between metabolic intermediates of Hz and cytochrome P-450. The trypan blue exclusion test, the measurement of K+ level and the determination of glutathione content retained in the cells were also performed. The results suggested that Hz is cytotoxic to isolated rat hepatocytes.View full abstractDownload PDF (1015K) -
ICHIZO OKABAYASHI, MICHIO KIMURA, HIDETOSHI FUJIWARA, AKIRA KATO1987 Volume 35 Issue 6 Pages 2545-2549
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSVarious dimethyl-substituted thioxanthones were prepared by the condensation reaction of 2-mercaptobenzoic acid and o-, m-, or p-xylene in sulfuric acid. Some of them are novel compounds (5, 11, 12, and 13). That is, from o-xylene, 1, 2-dimethyl (11) -, 2, 3-dimethyl (12) -, and 3, 4-dimethyl-thioxanthones (13) were formed in yields of 9.3, 37.1, and 12.8%, respectively. From m-xylene and p-xylene, 2, 4-dimethylthioxanthone (4) and 1, 4-dimethylthioxanthone (9), respectively, were obtained by the same condensation reaction. The structures were confirmed on the basis of spectral investigation and comparison with authentic materials obtained by another synthetic route : the cyclization of phenylthiobenzoic acids.View full abstractDownload PDF (791K) -
LUIZ JULIANO, MARIA A. JULIANO, ANTONIO DE MIRANDA, SATOSHI TSUBOI, YO ...1987 Volume 35 Issue 6 Pages 2550-2553
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSZ-Arg (Tos) -Pro-NHNHBoc (1) and Z-Arg (Tos) -Val-NHNHBoc (2) were prepared by the DCC, DCC-HOBt, DCC-DNp, mixed anhydride and DPPA methods. In each coupling reaction, lactam formation from the NG-tosylarginyl residue was observed, although the extent of formation was different depending not only on the carboxyl activation method but also on the kind of amino component. Addition of HOBt suppressed the formation of acylurea but did not suppress the formation of the lactam in the synthesis of 2. Addition of DNp suppressed the formation of the lactam slightly although it did not improve the yield of the target peptides. In the mixed anhydride method, a fairly large amount of the lactam was obtained in the synthesis of Z-Arg (Tos) -Pro-NHNHBoc, and a urethan-type derivative, Nα-isobutyloxycarbonyl-Pro-NHNHBoc, was also formed. However, in the case of synthesis of Z-Arg (Tos) -Val-NHNHBoc, lactam formation was suppressed compared with other activation methods and a small amount of urethan-type derivative was obtained. In both cases, the DPPA method gave a fairly good yield of the target peptide with only a trace amount of lactam formation.View full abstractDownload PDF (850K) -
YOSHIKO TSUDA1987 Volume 35 Issue 6 Pages 2554-2557
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSRacemic 2- (1-naphthoxy) propionic acid ((±) -1) and 2- (2-naphthoxy) propionic acid ((±) -4) were subjected to microbial reduction and simultaneous resolution with Glomerella cingulata (Malus and Prunus strains), Gloeosporium olivarum (G. olivarum) and Gloeosporium laeticolor (G. laeticolor), yielding (S) - (+) -2- (1-naphthoxy) propanol ((S) -2) and (R) - (+) -2- (2-naphthoxy) - propanol ((R) -5), and leaving (R) - (-) -2- (1-naphthoxy) propionic acid ((R) -1) and (S) - (-) -2- (2- naphthoxy) propionic acid ((S) -4), respectively. The optical purity of (S) - (+) -2- (1-naphthoxy) - propanol ((S) -2) reached 92% and over 99% ee when fermented with G. olivarum and Glomerella cingulata (Malus strain), respectively.View full abstractDownload PDF (677K) -
HIDENOBU OHMORI, TOSHIKATSU TAKANAMI, HIROE SHIMADA, MASAICHIRO MASUI1987 Volume 35 Issue 6 Pages 2558-2560
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSMichael addition of triphenylphosphine to α, β-unsaturated carbonyl compounds was effected in dichloromethane by the action of 2, 6-lutidinium salts to give the corresponding 3-oxoalkyl-triphenylphosphonium salts.View full abstractDownload PDF (438K) -
SUSUMU FUNAKOSHI, MINORU KUBOTA, NAOTO KOSUGA, JIAN-PING XU, HARUAKI Y ...1987 Volume 35 Issue 6 Pages 2561-2568
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESS[D-His2] Leu-enkephalin and [D-His2] adrenorphin were synthesized. In addition, eight [D-Arg2] enkephalin-related peptides were synthesized. Their inhibitory effects on electrically stimulated myenteric plexus-longitudinal muscle preparations of guinea-pig ileum were examined.View full abstractDownload PDF (1193K) -
YOSHIO TAKEDA, TETSURO FUJITA, TETSURO SHINGU, CHOEI OGIMI1987 Volume 35 Issue 6 Pages 2569-2573
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSFrom the bacterial gall of Myrica rubra, a new [7, 0] -metacyclophan (1) was isolated togetherwith three known compounds, myricanone (2), porson (3) and myricanol (4). The structure of the new compound was elucidated to be 5-deoxymyricanone (1) on the basis of spectroscopic evidence. The possible intermediacy of 1 in the biosynthesis of 2, 3 and 4 is discussed. DL-β-Phenyllactic acid was also isolated from the culture of Pseudomonas syringae pv. myricae pathogenic to the plant.View full abstractDownload PDF (923K) -
YUKIO OGIHARA, YINGJIE CHEN, YOSHIMASA KOBAYASHI1987 Volume 35 Issue 6 Pages 2574-2575
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSAlkaline cleavage of the glycosidic bonds of saponin D (2), obtained from the leaves of Hovenia dulcis, gave the genuine sapogenin, jujubogenin (1), saponin G (3) and a new compound (4) whose structure was characterized as 20-O-α-L-rhamnopyranosyljujubogenin on the basis of spectral analysis.View full abstractDownload PDF (267K) -
NAOHITO OHNO, YOSHIYUKI SUZUKI, KICHIRO SATO, SHOZO OIKAWA, TOSHIRO YA ...1987 Volume 35 Issue 6 Pages 2576-2580
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSThe antitumor activity of a (1→3) -β-D-glucan, grifolan, which was obtained from a fungus, Grifola frondosa, on the ascites form of Sarcoma 180 in ICR mice was examined. Grifolan was effective on the ascites tumor when it was administered before tumor transplantation (days-7--1) as a single dose of 2 mg/mouse by i.p. injection, but administration after the tumor transplantation was ineffective. The antitumor activity was transferred to untreated mice by injecting the peritoneal exudate cells obtained from grifolan-treated mice. The antitumor activity of grifolan was augmented by vaccination of mice with live sarcoma 180 cells (s. c. injection).View full abstractDownload PDF (666K) -
MASAYOSHI YAMAGUCHI, HIROSUKE SHIBANO1987 Volume 35 Issue 6 Pages 2581-2584
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSThe effect of a calcium-binding protein (CaBP) isolated from rat liver cytosol on pnos-phorylase α activity in the hepatic particulate glycogen was investigated. The particulate glycogen phosphorylase α activity was significantly increased by addition of Ca2+ in the range of 1.0-103 μM. This increase was not prevented by the presence of N- (6-aminohexyl) -5-chloro-1-napthalenesulfonamide (W-7 100 μM), an inhibitor of calmodulin. The elevation of phosphorylase α activity by 10 μM Ca2+ addition was significantly inhibited by the presence of CaBP at a concentration of greater than 3.0 μM. This inhibition was complete at 7.0 μM CaBP. CaBP itself had no effect on the enzyme activity. Of various metals (20 μM) used, addition of Zn2+ caused a significant decrease of the particulate glycogen phosphorylase α activity, while Mg2+ Mn2+ and Cd2+ had no effect on the enzyme activity. The presence of 3.5 μM CaBP did not block the inhibition of the enzyme activity by Zn2+ addition, indicating that CaBP uniquely reverses the Ca2+ effect. The present study suggests that CaBP regulates the effect of Ca2+ on phosphorylase α activity in the hepatic particulate glycogen of rats.View full abstractDownload PDF (545K) -
NAOHITO OHNO, MASUMI OHSAWA, KICHIRO SATO, SHOZO OIKAWA, TOSHIRO YADOM ...1987 Volume 35 Issue 6 Pages 2585-2588
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSGrifola frondosa produces an antitumor (1→3) -β-D-glucan, grifolan, which possesses two kinds of conformations in the solid state, i. e., helix (curdlan type) and native (laminaran type) (Ohno et al., Chem. Pharm. Bull., 34, 2555 (1986)). In this paper, the glucan conformation in the fruit body was examined by using carbon-13 cross polarization-magic angle spinning (CP/MAS) nuclear magnetic resonance (NMR) spectroscopy. Before analysis, the fruit body was treated as follows : amylase digestion, amylase digestion-periodate-borohydride treatment, hot water extraction, cold alkali extraction, or hot alkali extraction. Except for the cold and the hot alkali-extracted fruit bodies, all preparations showed C-3 signals at about 86 ppm, resembling those of the native form. These findings suggested that the (1→3) -β-D-glucan conformation in the fruit body is the “native form.”View full abstractDownload PDF (687K) -
YASUO MATSUSHITA, YAYOI KIJIMA (née SHIMIZU), IKUO MORIGUCHI1987 Volume 35 Issue 6 Pages 2589-2593
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSThe binding parameters of human serum albumin (HSA) and bovine serum albumin (BSA) with 14 benzoate derivatives and 2-naphthoate were determined by means of the ultracentrifugation method and the three-parameter equation previously proposed. The multiple regresssion analysis of the binding parameters revealed that the physico-chemical factors influencing the parameter α, which takes account of the increase in the binding capacity of albumin, were different in part between HSA and BSA. Moreover, the mean of the α values was greater with HSA than with BSA. This may indicate that HSA has a more flexible structure, and this may be consistent with lower contents of α-helix and β-sheet in the HSA molecule. Such differences were not recognized in the binding affinity of the serum albumins.View full abstractDownload PDF (564K) -
Takayuki Namiki, Yasutaka Suzuki, Kozo Sawada, Yoshikuni Itoh, Teruo O ...1987 Volume 35 Issue 6 Pages 2594-2597
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSWF-3681 (1a), an aldose reductase inhibitor, and its related compounds (1b-1j) have been synthesized by aldol condensation of phenylpyruvates and ω-formylalkanoates as a key step.View full abstractDownload PDF (370K) -
Hiroshi Irie, Kohei Matsumoto, Takao Kitagawa, Yong Zhang, Tamio Ueno, ...1987 Volume 35 Issue 6 Pages 2598-2601
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSTotal synthesis of the methyl esters of AK-toxin II and AF-toxin IIC, host-specific toxins to the susceptible cultivars Japanese pear and strawberry, was accomplished in optically active forms using vitamin C as a chiral material.View full abstractDownload PDF (365K) -
Kimiaki Isobe, Kunihiko Mohri, Manabu Maeda, Taroh Takeda, Yoshisuke T ...1987 Volume 35 Issue 6 Pages 2602-2604
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSThe skeleton of cocculolidine, a non-aromatic nor-erythrinan alkaloid, was synthesized in four steps from 14, 15, 17-trimethoxy-8- oxo-erythrinan by utilizing ozonolytic cleavage of an aromatic ring as a crucial step.View full abstractDownload PDF (297K) -
Hiroyuki Hayakawa, Hiromichi Tanaka, Naoko Itoh, Masako Nakajima, Tada ...1987 Volume 35 Issue 6 Pages 2605-2608
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSThe reaction of organolithium, Grignard, and organoaluminum reagents with 2'- and 3'-ketouridine derivatives was examined. For the reaction of 2', 5'-bis-0- (tert-butyldimethylsilyl) -3'-ketouridine, both organolithiums and organoaluminums seem to be practically useful. But only organoaluminums gave satisfactory yields in the reaction of 3', 5'-0- (tetraisopropyldisiloxan-1, 3-diyl) -2'-ketouridine.View full abstractDownload PDF (470K) -
Yuji Hanzawa, Kei-ichi Kawagoe, Yoshiro Kobayashi1987 Volume 35 Issue 6 Pages 2609-2612
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSFluoroalkyl alkynyl ketones (1a-c) were reduced enantioselectively by (R) -BINAL-H and (S) -Alpine-Borane to give optically active alcohols (2a-c). In the BINAL-H reduction, the trifluoromethyl group exerted an electronic effect on the enantioselectivity of the reagent.View full abstractDownload PDF (394K) -
Jiang-yu Liang, Zhi-da Min, Munekazu Iinuma, Toshiyuki Tanaka, Mizuo M ...1987 Volume 35 Issue 6 Pages 2613-2614
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSTwo new diterpenes, taxamairin A and B, were isolated from the bark of Taxus mairei. Their structures were determined by spectroscopic means, and finally confirmed by X-ray analysis.View full abstractDownload PDF (208K) -
Shin-ichiro Sakai, Toshio Okazaki, Keiichi Yamaguchi, Hiromitsu Takaya ...1987 Volume 35 Issue 6 Pages 2615-2617
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSChemical investigation of the roots of Aconitum subcuneatum Nakai resulted in the isolation of two new diterpene alkaloids torokonine (1) and gomandonine (2), along with eight known compounds, i.e. mesaconitine, jesaconitine, 14-dehydrobrowniine, neoline, 15-α-hydroxyneoline, isotalatizidine, senbusine A, and virescenine. The structure and the absolute configuration of torokonine (1) were established as 7-α-hydroxy ryosenamine from the spectroscopic analysis. The novel structure of gomandonine (2), having an epoxy ring, was initially deduced by the pyridine-induced solvent shift technique and then confirmed by X-ray analysis.View full abstractDownload PDF (354K) -
Kimiaki Isobe, Kunihiko Mohri, Yuji Itoha, Yuki Toyokawa, Naoko Takeda ...1987 Volume 35 Issue 6 Pages 2618-2621
Published: June 25, 1987
Released on J-STAGE: October 19, 2009
JOURNAL FREE ACCESSThe β-erythroidine skeleton was synthesized by two different routes; one was a four-step synthesis starting from 15, 16, 17-trimethoxy-8-oxo-cise-rythrinan, the other was a five-step synthesis starting from D-furano-8-oxo-cis-erythrinan. The two routes gave the same 14, 17-dihydro-16 (15H) -oxa-erythrinan-8, 15-dione (3).View full abstractDownload PDF (458K) -
1987 Volume 35 Issue 6 Pages 2622a
Published: 1987
Released on J-STAGE: February 12, 2010
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1987 Volume 35 Issue 6 Pages 2622b
Published: 1987
Released on J-STAGE: February 12, 2010
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1987 Volume 35 Issue 6 Pages 2622c
Published: 1987
Released on J-STAGE: February 12, 2010
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1987 Volume 35 Issue 6 Pages 2622d
Published: 1987
Released on J-STAGE: February 12, 2010
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1987 Volume 35 Issue 6 Pages 2622e
Published: 1987
Released on J-STAGE: February 12, 2010
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1987 Volume 35 Issue 6 Pages 2622f
Published: 1987
Released on J-STAGE: February 12, 2010
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