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Volume 34, Issue 9
Displaying 51-67 of 67 articles from this issue
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HIROSHI FURUKAWA, MOTOHARU JU-ICHI, ICHIRO KAJIURA, MASASHI HIRAI1986 Volume 34 Issue 9 Pages 3922-3924
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA new coumarin, ponfolin, was isolated from the root of Trifoliate Orange [Poncirus trifoliata (L.) RAF. (Rutaceae)], and its structure was determined as 1.View full abstractDownload PDF (378K) -
SEIICHI TESHIMA, TETSUYA KAJIMOTO, KIMIKO NAKANO, TOSHIAKI TOMIMATSU, ...1986 Volume 34 Issue 9 Pages 3925-3927
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA furostanol glycoside, methyl protodioscin (1), was converted to kryptogenin 3-O-β-chacotrioside (4), which is a key intermediate in the chemical transformation to the solanidane glycoside.View full abstractDownload PDF (388K) -
YOSHIHIKO INAMORI, MAYURI KUBO, HIROSHI TSUJIBO, MASAFUMI OGAWA, KIMIY ...1986 Volume 34 Issue 9 Pages 3928-3932
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSPodophyllotoxin (I), like deoxypodophyllotoxin (II), showed various biological activities. First, I had ichthyotoxic activity : the median tolerance limit at 48 h was 0.73 ppm in Oryzias latipes and 1.20 ppm in Carassius auratus. Second, I showed inhibitory activities on the growth of two plant species at a concentration of 50 ppm. Third, I showed insecticidal activities against all insects examined except for Spodoptera litura. A rather strong insecticidal activity toward Epilachna sparsa orientalis larvae was found, with mortality of 95% at 20 ppm. Futhermore, I and II had marked antitumor activities against L 5178 Y mouse leukemic cells in vitro [ID50 (μg/ml) : II, 0.0047 and I, 0.0054].View full abstractDownload PDF (524K) -
TAKESHI MIKAMI, SHIGEO SUZUKI, CONRAD SCHUERCH, MASUKO SUZUKI1986 Volume 34 Issue 9 Pages 3933-3935
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSApplications of polysaccharide antigens for enzyme linked immunosorbent assay (ELISA) were investigated. Two types of yeast mannan with or without branches and two synthetic linear mannans were examined for adsorbability on a polystyrene microtiter plate from a solution in 0.06 M bicarbonate-carbonate buffer (pH 9.6). Upon treatment with rabbit anti-mannan antibody, peroxidase-conjugated anti-rabbit immunoglobulin G antibody, and o-phenylenediamine plus hydrogen peroxide, the intensity of color in a microtiter plate pretreated with the mannans was linearly proportional to the concentration of these mannans.View full abstractDownload PDF (416K) -
TAKASHI YANO, AKIRA SHIMIZU, YUJI SAITO, HIRONOBU IINUMA, TOMIO TAKEUC ...1986 Volume 34 Issue 9 Pages 3936-3939
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA protease inhibitor was purified 700-fold from culture both of Streptomyces by butanol extraction, washing with ether, and chromatographies on silica gel, SP-Sephadex, and Bio-Gel P-2. This material specifically inhibited trypsin as well as a tissue-type plasminogen activator, but it only slightly inhibited the other type of plasminogen activator, urokinase, and did not inhibit other proteases tested.View full abstractDownload PDF (496K) -
MITSUO NAKAGAWA, TERUHIKO SHIMOKAWA, SHOJI KOJIMA1986 Volume 34 Issue 9 Pages 3940-3944
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSWhen rats were orally given olive oil for 4 d following the administration of polychlorinated biphenyls (PCBs, KC-400) for 4 d, the amounts PCBs in liver and adipose tissue were 62.16 and 931.6 μg/g tissue, respectively, while when rats were orally given clofibrate (CPIB) dissolved in olive oil instead of olive oil alone for 4 d following the administration of PCBs for 4 d, the amounts of PCBs in liver adipose tissue were effectively decreased to 33.70 and 448.8 μg/g tissue, respectively. In addition, when, after oral administration of PCBs for 4 d, rats were maintained by feeding a commercial diet for 14 d and then were orally given olive oil for 4 d, the amounts of PCBs in liver and adipose tissue were 7.70 and 201.4 μg/g tissue, respectively. However, when rats were orally given CPIB dissolved in olive oil instead of olive oil alone for 4 d in the same experimental system, the amount of PCBs (119.8 μg/g tissue) in adipose tissue was remarkably decreased, but that (8.10 μg/g tissue) in liver was unchanged. Further, the increased triglyceride and cholesterol contents in liver and serum of rats that had ingested PCBs were also decreased to the control levels or less by the administration of CPIB.These results suggest that the residual PCBs in the animal body can be effectively eliminated by CPIB treatment and also that hyperlipidemia and fatty liver induced by PCBs can be normalized by CPIB treatment.View full abstractDownload PDF (572K) -
Kiyoshi Tanaka, Xing Cheng, Teiji Kimura, Fumio Yoneda1986 Volume 34 Issue 9 Pages 3945-3948
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSUnder neutral conditions 5-arylidene 1, 3-dimethylbarbituric acid effectively oxidizes allylic and benzylic alcohols to the corresponding carbonyl compounds.There is a close relationship between oxidizing ability and electron density on the aromatic ring. The mechanism of this oxidation involves hydride transfer from the alcohol.View full abstractDownload PDF (383K) -
Kozaburo Nakano, Motoaki Ohashi, Shoichi Harigaya1986 Volume 34 Issue 9 Pages 3949-3952
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe β-glucosidation and β-glucuronidation of pantothenic acid (PaA) in dog liver microsome were compared with those of p-nitrophenol. PaA underwent β-glucosidation in the presence of uridine diphosphate glucose (UDPG). However, p-nitrophenol did not conjugate β-glucose but underwent β-glucuronidation in the presence of uridine diphosphate glucuronic acid (UDPGA). The UDP-glucuronyltransferase effect on p-nitrophenol was 1000 times larger than the UDP-glucosyltransferase effect on PaA. But no glucuronidation of PaA occurred. The optimum pH for the glucosidation of PaA was 8.5. These results indicate that PaA has a high specificity for β-glucosidation, and that β-glucosidation is an essential pathway in the metabolism of PaA in dogs.View full abstractDownload PDF (434K) -
Yuji Hanzawa, Kei-ichi Kawagoe, Nobuyuki Kimura, Yoshiro Kobayashi1986 Volume 34 Issue 9 Pages 3953-3955
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe stereoselective synthesis of trifluoromethylated z-olefins (6__∼) was achieved through the Claisen rearrangement of 1, 1, 1-trifluoropropenyl-2-carbinol derivatives (5__∼ and 7__∼). The olefins (6__∼) were converted to trifluoromethylated diene, which was used as a key intermediate in the synthesis of trifluororetinal.View full abstractDownload PDF (346K) -
Masataka Mochizuki, Takako Anjo, Naoko Sekiguchi, Atsuko Ikarashi, Ats ...1986 Volume 34 Issue 9 Pages 3956-3959
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe kinetics of solvolysis of some α-acetoxy nitrosamines in phosphate buffer solution was investigated and their mutagenic products were identified. N-Nitroso-N-(1-acetoxyalkyl)alkylamines were decomposed in two ways in aqueous phosphate buffer solution : O-acyl fission yielded α-hydroxy nitrosamines which were decomposed into aldehydes and alcohols, while O-alkyl fission gave a resonance hybrid of α-N-nitroso carbonium and iminium ions which, when trapped with phosphate, afforded N-nitroso-N-(1-phosphonooxyalkyl)alkylamines. They were stable in neutral and alkaline aqueous solutions, and were mutagenic in Salmonella typhimurium TA1535 and Escherichia coli WP2 and WP2 hcr-.View full abstractDownload PDF (455K) -
Satoshi Iwakami, Masaaki Shibuya, Chen-Fang Tseng, Fumio Hanaoka, Ushi ...1986 Volume 34 Issue 9 Pages 3960-3963
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSome cinnamoyl-β-phenethylamine derivatives, gingerols, diarylheptanoids and acyldopamines were tested for their inhibitory effects on the 5-lipoxygenase of RBL-1 cells. Compounds containing a catechol group together with a lipophilic group strongly inhibited 5-lipoxygenase. Significant inhibition was also observed in gingerols having guaiacol instead of catechol. Linoleoyl- and linolenoyl-dopamines were the strongest 5-lipoxygenase inhibitors.View full abstractDownload PDF (422K) -
Hidenori Hayashi, Fumie Hashimoto, Kazuyo Nakata1986 Volume 34 Issue 9 Pages 3964-3967
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe effect of a high cholesterol diet on rat liver peroxisomal enzymes was investigated. Chow containing 2% cholesterol was given for 14 days to rats initially weighing ca. 200 g. The cholesterol levels of the blood and liver were elevated and the activities of the hepatic peroxisomal fatty acyl-CoA β-oxidizing system (FAOS) and fatty acyl-CoA oxidase (FAO), a rate-limiting enzyme, were significantly increased (approximately 1.4- and 1.5-fold, respectively). Other groups of the rats were fed a normal diet or a 2% cholesterol diet for 7 days. Then clofibrate (40 mg) was intraperitoneally administered daily to both groups for 7 days, all the while the rats continued to receive the same diet as before. Though clofibrate treatment alone enhanced the peroxisomal FAOS and FAO activities of the liver (4.3-fold for FAOS and 13.5- fold for FAO), both activities were further increased significantly in rats on the 2% cholesterol diet (approximately further 1.4- and 1.3-fold, respectively). The high cholesterol diet failed to increase catalase and urate oxidase activities, which are not directly related to fatty acid β-oxidation. Cholesterol is a probable physiological substrate for liver peroxisomes, and thus the particles are considered to be induced by various substrates : not only long-chain fatty acids, but also cholesterol.View full abstractDownload PDF (428K) -
Takashi Katsu, Mieko Kanamitsu, Takashi Hirota, Kenji Tasaka, Yuzaburo ...1986 Volume 34 Issue 9 Pages 3968-3970
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSWe constructed a histamine-sensitive membrane electrode by using sodium tetrakis(p-fluorophenyl)borate as an ion-exchanger and o-nitrophenylphenylether as a membrane solvent and applied it in the detection of histamine released from mast cells. This is the first attempt to measure the histamine secretion process in situ without any separation of histamine from the assay medium.View full abstractDownload PDF (356K) -
Masanori Somei, Hirokuni Amari, Yoshihiko Makita1986 Volume 34 Issue 9 Pages 3971-3973
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA new coupling reaction for unsymmetrical biaryls was developed and applied successfully to the syntheses of 4-arylindoles. Photoreaction of 4-halogenoindoles also proved to be a useful method for preparing 4-substituted indoles. An alternative method for synthesizing 4-(3-pyridyl)-3-indolecarbaldehyde is also reported.View full abstractDownload PDF (374K) -
Ryoji Kasai, Masazumi Miyakoshi, Kazuhiro Matsumoto, Rui-Lin Nie, Jun ...1986 Volume 34 Issue 9 Pages 3974-3977
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAn oleanane type triterpenoid saponin, named tubeimoside I was isolated from tubers of Bolbostemma paniculatum (Maxim.) Franguet (Cucurbitaceae), a Chinese folk medicine, "Tu Bei Mu". Its novel cyclic structure, including the chirality of the 3-hydroxy-3-methylglutarate moiety, is reported. The name cyclic bisdemoside is proposed for this type of saponin. The potent Solubilizing effect of this compound is also described.View full abstractDownload PDF (435K) -
Fujio Imai, Takeshi Kinoshita, Akiko Itai, Ushio Sankawa1986 Volume 34 Issue 9 Pages 3978-3981
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSOn treatment with acid, the well-known epoxy coumarin phebalosin (I) undergoes rearrangement to afford murralogin, a naturally occurring coumarin bearing an unusual isoprenoid unit. The structure of murralogin is reviewed, based on the hypothetical mechanism of rearrangement, and finally revised to (V) by X-ray crystalography.View full abstractDownload PDF (395K) -
Kazuki Saito, Sih Tsai, Shigeru Ohmiya, Hajime Kubo, Hirotaka Otomasu, ...1986 Volume 34 Issue 9 Pages 3982-3985
Published: September 25, 1986
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA new lupin alkaloid, (+)-13β-hydroxymamanine, was isolated from the stems of Maackia amurensis var. buergeri (Leguminosae). Its structure was determined by spectroscopic analysis and by chemical transformation to its acetate and N-oxide.View full abstractDownload PDF (390K)