巻号一覧
21 巻, 3 号
選択された号の論文の7件中1～7を表示しています
- |<
- <
- 1
- >
- >|
-
特に生菌ならびにクロームワクチン前処置マウスの“感染死”防禦効果について阿部 実1966 年 21 巻 3 号 p. 125-132
発行日: 1966/03/25
公開日: 2009/02/19
ジャーナル フリーPreviously it was reported that the mice infected with a sublethal and kidney abscess forming dose of St. aureus No.248 βH strain could have a strong and stable resistance to the two weeks later superinfection with the homologous staphylococcal strain. This experimental evidence would provide much advances in the experimental approach to the analysis of the staphylococcal infection and its immunity. However in this experiment it must be considered that the very large dose of bacterial cells injected intravenously for the preinfection could have induced the so-called non-specific resistance though the RES organs of the infected mice.
The present auther carried out the experiments analyse the possibility of the nonspecificity in the resistance of the infected mice above mentioned. The intraperitoneal route was employed for the pretreatment of the mice in order to avoid the kidney abscess formation, because Kondo et al ascribed one of the most efficient factors providing the resistance to the infected mice to the formation of the kidney abscess and its liberation of somewhat unknown immunological agents.
Experimental results are as follows:
1) The mice pretreated with living vaccine of St. 248 βH through the intraperitoneal route could show an extremely increased resistance to the 48 hours later superinfection with the same staphylococcal strain of lethal dose injected intravenously as well as intraperitoneally.
2) The mice pretreated with the chrome killed vaccine of the staphylococcal strain No.248 βH could also resist to the super infection with the same strain, though it took 10 times as much dose of this killed vaccine to give the same efficient effect as the one of the living vaccine.
3) Similar resistance inducing effects were shown by the pretreatment with the chrome killed vaccine of various other staphylococcal strains different from St. 248 βH strain.
4) The results of the analytical experiments on the specificity of this early arising resistance showed that it was nonspecific at least in the relationship between the two strains employed for the pretreatment and the superinfection.
5) Therfore, the resistance inducing factor can be considered to be contained in the staphylococcal cells and fixed in their chrome killed vaccine. The content of this factor seems to be different in various staphylococcal strains and and at least different from the coagulase factor.抄録全体を表示PDF形式でダウンロード (1104K) -
竹原 学1966 年 21 巻 3 号 p. 133-140
発行日: 1966/03/25
公開日: 2009/02/19
ジャーナル フリーAn infective subviral agent (SVA) was isolated from the rabbit kidney (RK) cells infected with rabbit myxoma (South American Sanarelli strain) or Shope fibroma (OA strain) virus, When some properties of the SVA were examined briefly, they differed apparently from typical mature particles of myxoma-fibroma viruses in a few point.
Some experimental methods and results obtained are summarized as follows:
The SVA of myxoma virus was found in the virus-infected RK cell lysates after infection for 1, 4 and 6 hours. On the other hand, the SVA of fibroma virus was present in the virus-infected cell lysates after infection for 1 and 8 hours. Both myxoma and fibroma SVAs can be completely separated from the typical mature virus particles (about 200-300mμ in diameter) by ultrafiltration through 50mμ Millipore filters.
Both myxoma and fibroma SVAs revealed infectivity by being inoculated into the RK cell culture and injected intradermally into rabbits as well as the complete virus particles. Their infectivities were not affected by the action of DNA-ase (2μg/ml) at 37°C for 30 minutes.
Infectivity of the SVA from myxoma virus-infected cells was inactivated markedly more than that of myxoma virus by the effect of trypsin (100μg/ml) at 37°C for 30 minutes, and also neutralized completely after incubation at 37°C for 1 hour with anti-myxoma immune rabbit serum. When thermal inactivation rate of both myxoma SVA and virus was determined by incubation at 37°C for 30 minutes, surviving fraction of the SVA was less than 50% as compared with that of myxoma virus.
As speculation on these experimental results, the myxoma-fibroma subviral agents appear to contain protein and DNA, but they may be smaller particles than typical myture myxoma-fibroma virus particles. The fact that the myxoma SVA could be detected after infection for 1, 4 and 6 hours seems to be closedly related to time of the growth cycle of this virus. Thus, the SVA which is detectable in earlier stage of the infection may differ from the agent found in later stage of the infection.抄録全体を表示PDF形式でダウンロード (922K) -
I. 副作用および抗体反応について中村 観善, 奥野 良臣1966 年 21 巻 3 号 p. 141-146
発行日: 1966/03/25
公開日: 2009/02/19
ジャーナル フリーField trials of live influenza vaccine, produced in our laboratory, were carried out in Osaka in November 1964. Febrile reactions were observed in 262 out of 13, 894 persons (1.9%) and mean maximal fever was 37.6°C. Mean incubation period and duration of fever were 20.1 and 12.5 hours respectively. Persons needed to stay away from work or school were 101 (0.7%) and mean period to be away from work was 1.4 days. Lassitude, headache, rhinorrhea, pharyngeal pain and cough were observed in 3.0%, 4.5%, 1.6%, 1.7% and 1.8% respectively. No differences were observed in clinical reactions between adults and children. Four fold or higher HI antibody response was observed in 31 out of 73 susceptible persons (44%).抄録全体を表示PDF形式でダウンロード (536K) -
熱海 明, 小野 精美, 石田 名香雄, 今野 二郎, 多田 孝太郎, 大谷 サチ子1966 年 21 巻 3 号 p. 147-150
発行日: 1966/03/25
公開日: 2009/02/19
ジャーナル フリーAs no critical and reliable reports on the isolation of influenza C virus have appeared so far in Japan for the past two decades, an isolation of influenza C virus from a sporadic case in Yamagata Prefecture was reported. The strain designated as C/Yamagata/64 was quite related to either C/1233/47 or C/JJ/50 as far as several biological characteristics are concerned. However, serologic test revealed the clear-cut antigenic difference among these three, reflecting the chronological sequence of their isolation. The receptor for influenza C was found to be quite different and independent from those for influenza A, B and mumps viruses.抄録全体を表示PDF形式でダウンロード (440K) -
前処置マウスにおける諸種感染症や各種細胞移植に対する抵抗性の増強について沖津 富士夫1966 年 21 巻 3 号 p. 151-163
発行日: 1966/03/25
公開日: 2009/02/19
ジャーナル フリーIn the present investigation, an attempt was made to find whether there is a fundamental difference between non-specific resistance and acquired specific immunity, by comparing the degree of protection against various bacterial and protozoal infections and resistance to various transplantation of the mice and the rats pre-treated by zymosan, a non-specific stimulant, with those of the animals specifically immunized.
The results obtained are as follows:-
(1) When infected by such bacteria as Diplococcus pneumoniae (100A strain), Staphylococcus aureus (Smith strain) and Salmonella typhosa (Ty-2 strain) which connot be multiplied in the phagocytes of a mouse, the zymosan-treated mice demonstrated markedly strong resistance. On the other hand, when infected by Salmonella enteritidis (No, 11 Strain) or Toxoplasma gondii (RH strain), no difference from the non-treated mice was recognized and all the mice died.
(2) Three different types of grafts were performed: Xenogeneic graft-ascites hepatoma AH39 strain indigenous to rat-to a mouse; allogeneic graft-AH39 tumor cells-to a rat of an inbred Wistar strain; syngeneic graft-ascites hepatoma MH134 indigenous to C3H mouse-to a mouse of C3H/HeN strain.
In all of the three cases, rejection of the graft was accelerated when the recipients were pretreated by zymosan. Stronger acceleration was recognized, hewever, in the xenogeneic and allogeneic grafts, while lower in the syngeneic transplants.
(3) The death by neoplasma of the zymosan-treated mice was slightly delayed, compared with that of the non-treated mice, when inoculated subcutaneously by 20-methylcholanthrene.
(4) Variation in response of the mice administered by zymosan in abdomen to Diplococcus pneumoniae 100A strain was examined periodically. Also the acid phosphatase activity of the peritoneal exudative cells of the pre-treated mice was measured at the same time.
It was indicated, as the result, that the variation in response to the bacterial infection closely paralles the enzymatic activity of the peritoneal exudative cells. That is, both decreased for the first several hours after the administration of zymosan, exceeded the normal value after 24 hours and maintained this value for approximately 1 week. Then they decreased rapidly to resume the normal value within 2 weeks.抄録全体を表示PDF形式でダウンロード (1732K) -
室橋 豊穂, 吉田 幸之助, 加藤 睦子1966 年 21 巻 3 号 p. 164-170
発行日: 1966/03/25
公開日: 2009/02/19
ジャーナル フリーEffect of ultraviolet irradiation on the acidfastness was studied on the drug resistant mutants of tubercle bacilli. Among them, resistant strains to more than 1γ/ml of Isoniazid lost acidfastness, similarly to the avirulent or attenuated ones, by shorter time of UV irradiation than the virulent tubercle bacilli. This phenomenon correlated very well with the pronounced attenuation in virulence to guinea pigs by subcutaneous inoculation. Based on the results, mechanism of Isoniazid resistance was discussed from the standpoint of cell wall structure.抄録全体を表示PDF形式でダウンロード (837K) -
1966 年 21 巻 3 号 p. 171-192
発行日: 1966/03/25
公開日: 2009/02/19
ジャーナル フリーPDF形式でダウンロード (3282K)
- |<
- <
- 1
- >
- >|